<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04535
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MAELGQQTVDFSTLVSRAAEDSFISLKELVEKSKSSDMSDSEKKINLLKFIVKTQQRMLRLNVLAKWCQQVPLVQYCQQLASTLSSHDTCFSQTADSLYFMHEGLQQARAPMYDVPSAIEVLLTGSYERLPKCIEDVGMQSSLNEVQQKPALRKLDILVRSKLLETTLPKEISEVKVSDGTALLRVDGEFQVLVTLGYRGHLHLWRILHMELLVGERSGAIKLEELRRFALGDDLERRMAAADEQQNPFMILYSVLHEFCVALIMDTVIRQVHALRQGRWKDAIKFELISDGSTTQGASTSSTQLSQDGEYEASGQRTPGVKIVYWLDLDKNSGTSDGGACPFIKIEPGPNLQIKCIHSTFVIDPSTGKEAEFYLDLSCIDVEKLLLKAIRCNRYTRLLEINKELTKNCQIFRGDGDVLLHCNKDETEVDHKKKDAGSIAKESDGQEVLFVRAYGSSFFILGINIRNGRYQLQSSRNIITPSVLSDSEEILNQGSLSAAEIFVNLRSKSILHLFASIGKFLGLEVFENGFSSVKVPKDILIGASFLLMGFPDCGSSYFLLMQLDKEFKIVFELVEKQPEPGKSSNFIVGRVKKIDVGQMQMLEDEMNLSILDVRKVGAFMPGAVIPNQSSDYGLLSNFGHDGLMSVTLCPPSSFSSVVDEVFELEKGTSGPYSVPNISSSISTSAAHLGSLPLNLPSSKVGTVSPKREGNAQLSHINPAVKFSTHYNGSLYQGAHVKGLSQSSSVSSLPFSQQRHNAMQKLSVSKSEQDLASLRSPQSVEVSSFRSMDEDHPRFTNEQSRDVISGRSLRLSSLQSAVARVSVSDANGTAVKSWATTPVYAGCRTVSEHDKDSKKRKVSDMLNSLPLLRGLADGASKRRKVSTDQPSVYSAISSNTICNPEGYTYGNLLADANKGNAPSGVYISALLHVVRHCSLCIKHAMLTSQMEALDIPFVEETGLNAFVNIWFRLPSARGNSWPHICLRLGKPGSLCWDVKINDQHFRDLWELQKGSSNTPCGSGVRIANTSDVDSHIRYDSEGVILIYSSVEVDSIKRLVADIHRLSNARLFALGMRKLLGVKTEERLEEGANSDCKPLNGAKGSTEGVGKFSEQMRRTFRIEAVGLLSLWFSFGSGVLARFVVEWESGREGCTMHVSPDQLWPHTKFLEEYINGGEVASLLDCIRLTAGPLHALAAATRPARAGQPAIVPGAGSTIPASSRQGTYVSAQGIPPSSVSPNVGQGAASSAGISVSSAATAALGNHAGVMLAAAGRGGSGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLEPNFVGGQLTVGLSSSNNLNPGLSPPLATVNGSRVTLPGASGLSRPGNQVSGVNRAGNSLSVPSNIAAVGAGLALRRPPAAGGAAHVKGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHNQQQQQQQNPASAQEELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKVMSQSQGGDVAPAQKPRIELCLENHAGLNMDGVSGNLSATKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGEAPTVSFLGMEGSHGGRACWLRVDEWEICKQRVARAIEVPGSSPADIAQGRLRLVADNVQRALHLCLQGLRDNTGVGVPGTSGAT |
Length | 1787 |
Position | Tail |
Organism | Spinacia oleracea (Spinach) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
Caryophyllales> Chenopodiaceae> Chenopodioideae> Anserineae> Spinacia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.113 |
Instability index | 45.11 |
Isoelectric point | 7.83 |
Molecular weight | 193950.06 |
Publications | PubMed=24352233
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP04535
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 661.68| 180| 225| 1097| 1318| 1
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948- 1094 (179.18/86.47) .........................LDIPFVEETG.LNAFVNIWfrlPSARGNS.........WPHI......CLRLGKPGSL..CwdVKINDQHFRDLwelqkGSSNTPCGSGvRIANTSDVDSHIR.YD..S.EGVILIYSSVEVDSIK.R.LVADIH......RLSNARLFALGMRK.LLG......VKTEERLEEG.ANSDCKPLN.......
1097- 1289 (287.99/215.48) KGSTEGVGKFSEQMRRTFRIEAVGlLSLWFSFGSGvLARFVVEW...ESGREGCtmhvspdqlWPHTKFLE.EYINGGEVASLldC..IRLTAGPLHAL.....AAATRPARAG.QPAIVPGAGSTIP.AS..SRQGTYVSAQGIPPSSVS.P.NVGQGAASSAGISVSSAATAALGNHA.GVM......LAAAGRGGSGIVPSSLLPIDVSVVLRG
1322- 1471 (194.51/93.11) KGGPSVGGSLPCPQFRPFIMEHVA........................................QELNGLEpNFVGG............QLTVG.LSS......SNNLNPGLSP.PLATVNGSRVTLPgASglSRPGNQVSGVNRAGNSLSvPsNI...AAVGAGLALRRPPAAGGAAHVkGELntaiigLGDDGGYGGGWVPL....VALKKVLRG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 150.88| 46| 97| 509| 558| 2
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509- 558 (67.54/50.07) SILHLfASIGKFLGLEVFENGFSSVKVPKDilIGASfLLMGFPDCGSSYF
609- 654 (83.34/46.42) SILDV.RKVGAFMPGAVIPNQSSDYGLLSN..FGHD.GLMSVTLCPPSSF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 84.41| 19| 20| 671| 689| 4
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671- 689 (31.11/19.44) PYSVPNISSSIST.SAAHLG
692- 709 (23.85/12.95) PLNLP..SSKVGTvSPKREG
710- 728 (29.44/17.95) NAQLSHINPAVKF.STHYNG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.47| 10| 20| 849| 858| 5
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849- 858 (18.16/11.90) DKDSKKRKVS
872- 881 (18.31/12.06) DGASKRRKVS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 97.75| 30| 97| 215| 250| 6
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215- 250 (41.54/47.80) GERSGAIKLeelrRFALgdDLERRMAAADEQQNPFM
315- 344 (56.21/41.81) GQRTPGVKI....VYWL..DLDKNSGTSDGGACPFI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.86| 10| 19| 777| 786| 11
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777- 786 (17.71/11.54) QSVEVSSFRS
798- 807 (18.15/12.06) QSRDVISGRS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.89| 10| 15| 899| 908| 17
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899- 908 (19.42/12.12) PEGYTYGNLL
917- 926 (17.47/10.06) PSGVYISALL
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