<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04535

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSTLVSRAAEDSFISLKELVEKSKSSDMSDSEKKINLLKFIVKTQQRMLRLNVLAKWCQQVPLVQYCQQLASTLSSHDTCFSQTADSLYFMHEGLQQARAPMYDVPSAIEVLLTGSYERLPKCIEDVGMQSSLNEVQQKPALRKLDILVRSKLLETTLPKEISEVKVSDGTALLRVDGEFQVLVTLGYRGHLHLWRILHMELLVGERSGAIKLEELRRFALGDDLERRMAAADEQQNPFMILYSVLHEFCVALIMDTVIRQVHALRQGRWKDAIKFELISDGSTTQGASTSSTQLSQDGEYEASGQRTPGVKIVYWLDLDKNSGTSDGGACPFIKIEPGPNLQIKCIHSTFVIDPSTGKEAEFYLDLSCIDVEKLLLKAIRCNRYTRLLEINKELTKNCQIFRGDGDVLLHCNKDETEVDHKKKDAGSIAKESDGQEVLFVRAYGSSFFILGINIRNGRYQLQSSRNIITPSVLSDSEEILNQGSLSAAEIFVNLRSKSILHLFASIGKFLGLEVFENGFSSVKVPKDILIGASFLLMGFPDCGSSYFLLMQLDKEFKIVFELVEKQPEPGKSSNFIVGRVKKIDVGQMQMLEDEMNLSILDVRKVGAFMPGAVIPNQSSDYGLLSNFGHDGLMSVTLCPPSSFSSVVDEVFELEKGTSGPYSVPNISSSISTSAAHLGSLPLNLPSSKVGTVSPKREGNAQLSHINPAVKFSTHYNGSLYQGAHVKGLSQSSSVSSLPFSQQRHNAMQKLSVSKSEQDLASLRSPQSVEVSSFRSMDEDHPRFTNEQSRDVISGRSLRLSSLQSAVARVSVSDANGTAVKSWATTPVYAGCRTVSEHDKDSKKRKVSDMLNSLPLLRGLADGASKRRKVSTDQPSVYSAISSNTICNPEGYTYGNLLADANKGNAPSGVYISALLHVVRHCSLCIKHAMLTSQMEALDIPFVEETGLNAFVNIWFRLPSARGNSWPHICLRLGKPGSLCWDVKINDQHFRDLWELQKGSSNTPCGSGVRIANTSDVDSHIRYDSEGVILIYSSVEVDSIKRLVADIHRLSNARLFALGMRKLLGVKTEERLEEGANSDCKPLNGAKGSTEGVGKFSEQMRRTFRIEAVGLLSLWFSFGSGVLARFVVEWESGREGCTMHVSPDQLWPHTKFLEEYINGGEVASLLDCIRLTAGPLHALAAATRPARAGQPAIVPGAGSTIPASSRQGTYVSAQGIPPSSVSPNVGQGAASSAGISVSSAATAALGNHAGVMLAAAGRGGSGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLEPNFVGGQLTVGLSSSNNLNPGLSPPLATVNGSRVTLPGASGLSRPGNQVSGVNRAGNSLSVPSNIAAVGAGLALRRPPAAGGAAHVKGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHNQQQQQQQNPASAQEELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKVMSQSQGGDVAPAQKPRIELCLENHAGLNMDGVSGNLSATKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGEAPTVSFLGMEGSHGGRACWLRVDEWEICKQRVARAIEVPGSSPADIAQGRLRLVADNVQRALHLCLQGLRDNTGVGVPGTSGAT
Length1787
PositionTail
OrganismSpinacia oleracea (Spinach)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> Caryophyllales> Chenopodiaceae> Chenopodioideae> Anserineae> Spinacia.
Aromaticity0.07
Grand average of hydropathy-0.113
Instability index45.11
Isoelectric point7.83
Molecular weight193950.06
Publications
PubMed=24352233

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04535
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     661.68|     180|     225|    1097|    1318|       1
---------------------------------------------------------------------------
  948- 1094 (179.18/86.47)	.........................LDIPFVEETG.LNAFVNIWfrlPSARGNS.........WPHI......CLRLGKPGSL..CwdVKINDQHFRDLwelqkGSSNTPCGSGvRIANTSDVDSHIR.YD..S.EGVILIYSSVEVDSIK.R.LVADIH......RLSNARLFALGMRK.LLG......VKTEERLEEG.ANSDCKPLN.......
 1097- 1289 (287.99/215.48)	KGSTEGVGKFSEQMRRTFRIEAVGlLSLWFSFGSGvLARFVVEW...ESGREGCtmhvspdqlWPHTKFLE.EYINGGEVASLldC..IRLTAGPLHAL.....AAATRPARAG.QPAIVPGAGSTIP.AS..SRQGTYVSAQGIPPSSVS.P.NVGQGAASSAGISVSSAATAALGNHA.GVM......LAAAGRGGSGIVPSSLLPIDVSVVLRG
 1322- 1471 (194.51/93.11)	KGGPSVGGSLPCPQFRPFIMEHVA........................................QELNGLEpNFVGG............QLTVG.LSS......SNNLNPGLSP.PLATVNGSRVTLPgASglSRPGNQVSGVNRAGNSLSvPsNI...AAVGAGLALRRPPAAGGAAHVkGELntaiigLGDDGGYGGGWVPL....VALKKVLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.88|      46|      97|     509|     558|       2
---------------------------------------------------------------------------
  509-  558 (67.54/50.07)	SILHLfASIGKFLGLEVFENGFSSVKVPKDilIGASfLLMGFPDCGSSYF
  609-  654 (83.34/46.42)	SILDV.RKVGAFMPGAVIPNQSSDYGLLSN..FGHD.GLMSVTLCPPSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.41|      19|      20|     671|     689|       4
---------------------------------------------------------------------------
  671-  689 (31.11/19.44)	PYSVPNISSSIST.SAAHLG
  692-  709 (23.85/12.95)	PLNLP..SSKVGTvSPKREG
  710-  728 (29.44/17.95)	NAQLSHINPAVKF.STHYNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.47|      10|      20|     849|     858|       5
---------------------------------------------------------------------------
  849-  858 (18.16/11.90)	DKDSKKRKVS
  872-  881 (18.31/12.06)	DGASKRRKVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.75|      30|      97|     215|     250|       6
---------------------------------------------------------------------------
  215-  250 (41.54/47.80)	GERSGAIKLeelrRFALgdDLERRMAAADEQQNPFM
  315-  344 (56.21/41.81)	GQRTPGVKI....VYWL..DLDKNSGTSDGGACPFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.86|      10|      19|     777|     786|      11
---------------------------------------------------------------------------
  777-  786 (17.71/11.54)	QSVEVSSFRS
  798-  807 (18.15/12.06)	QSRDVISGRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.89|      10|      15|     899|     908|      17
---------------------------------------------------------------------------
  899-  908 (19.42/12.12)	PEGYTYGNLL
  917-  926 (17.47/10.06)	PSGVYISALL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04535 with Med14 domain of Kingdom Viridiplantae
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