<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04461

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMQSAAIEATIPVVDRQLVVVVEGTAALGPHWSTIFSDYLEKIIRSFCGNEVPSEQPQNTLDSRPDLGLVMFYAHGPYSEGDVQQTIWINDTDRFLQMLKGLRFNGGGFSDSCVTEGLAEALLMFGVNSNGSHSQPRPDCHKHCILVAASNPYPIETYIYKYVPQNTETRRNCSVPMEAYLSDAVMVAKRFSQFPYSLSVISARQLPKLQEVYDAGKHNPQAVDHPVTDKKNPYFLVLISDNFVEASNALSRPAVKLQPSQGIINVDGPSGSSSISSISATMKNRHTVAVGHSPVDLVEVEPAVSGFCHPSPIMNATAQGGTILPSSTPSPVRQEMNTNPESVQEFKPVINPMSQTLRPVGPAAANMNILNNLSQHSHARQVINSASIGGGTSMGVKPMAIHMSNMISNGMVSSALSGMQSIPTSGALIETSQAAQNTAMGSLVTTNNSNLQQVNVGVGQSLPPNVGQASLNSASQFGPNVISINQTSLNNSLGASNISSGAGTMMPTPGMSQSAQAGLNYLDATNGSTMNMPSQQNAPGAQQPQSKYTKIWVGSLSGKRQGQPVFICKLEGYRSTTASDKLADDWPETMQIVRLISQDHMNNKQYAGKADLLVFRPLNPHGFLGQLHDKKLCAVIQLPSQTLLLSVIDKMTRLIGMLFPGDMVVFKPQASNQPQLQLQLQQQQNQNQQQQQIQQQNQPQQNQQQQRSQMIGVGLNQSFVQGSTRTQMMSQQGQGNMQGQGNMQGGNFLS
Length749
PositionUnknown
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.05
Grand average of hydropathy-0.335
Instability index49.95
Isoelectric point7.26
Molecular weight80833.44
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.71|      16|      16|     674|     689|       1
---------------------------------------------------------------------------
  674-  689 (29.24/11.66)	QLQLQLQQQQNQNQQQ
  691-  706 (30.31/12.35)	QIQQQNQPQQNQQQQR
  722-  737 (27.16/10.32)	STRTQMMSQQGQGNMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.28|      33|      36|     346|     378|       2
---------------------------------------------------------------------------
  311-  346 (41.94/23.76)	PIMNATA...QggTILPSstpSPVRQEM.N..TNPESVQEFK
  347-  379 (58.61/36.35)	PVINPMS...Q..TLRPV...GPAAANM.NILNNLSQHSHAR
  380-  408 (26.73/12.27)	QVINSASiggG..TSMGV...KPMAIHMsNMISN........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.52|      17|      48|     598|     616|       3
---------------------------------------------------------------------------
  598-  616 (28.18/28.75)	DHM...NNKQYAGkaDLLVFRP
  648-  667 (28.34/20.79)	DKMtrlIGMLFPG..DMVVFKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.01|      46|     165|     246|     293|       4
---------------------------------------------------------------------------
  246-  293 (73.59/48.30)	SNALSrpAVKLQPSQG.IINVDGPSGSSSISSISATMK...NRHTVAVGHS.P
  412-  462 (62.42/34.24)	SSALS..GMQSIPTSGaLIETSQAAQNTAMGSLVTTNNsnlQQVNVGVGQSlP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.53|      46|     105|      23|      70|       5
---------------------------------------------------------------------------
   23-   70 (74.44/60.62)	GTAALGPHwSTIFSDYLEKIIRSFCGNEVPSEQ......PQNTlDSRPDLGLVM
  125-  176 (82.09/55.62)	GVNSNGSH.SQPRPDCHKHCILVAASNPYPIETyiykyvPQNT.ETRRNCSVPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.91|      13|      15|     467|     481|       6
---------------------------------------------------------------------------
  467-  481 (18.52/15.09)	QASLNSAsqFGPNVI
  485-  497 (22.39/11.43)	QTSLNNS..LGASNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04461 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQGGTILPSSTPSPVRQEMNTNPESVQEFKPVINPMSQTLR
2) LGASNISSGAGTMMPTPGMSQSAQAGLNYLDATNGSTMNMPSQQNAPGAQQP
3) QLQLQLQQQQNQNQQQQQIQQQNQPQQNQQQQRS
317
492
674
357
543
707










Molecular Recognition Features






MoRF SequenceStartStop




NANANA