<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04455

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYSSSNRGGGFSNNAVGGTTSLRDRVDPSLSSNFSVNSRKLSQLLPYKLKCEKESLSFRLGPPDFYPQAPNCPEETLTREYLLSGYKETVEGIEESQEITLTHIRHHSKPVILKCKEAIKKHLRTINESRAQKRKAGQVYGVPLSGKLLLKPGIFPEQKQVGEDARKKWIEGLSQRHKHLRLLADNVPHGYRKKGLLEVIIRHNVPILRATWFIKVTYLNQIRPTTGGISSGTLDKSQFVRTESWTKDLIEYMQHLLDKFLTKDGISPQRGSRDQTSQILAPCSSHRRNDLLPSVTNAGDPSLQVKWDYVMRLLIWNCSEGLLFPSLILEWVLSQLQAKDSVDVLEFLLPIIVDLAESVSLSQIYIRLFADIAVRFLQNLCQGGMDTVANAKKPHLASPLVELLRYLLLSTPDAFVGLDCFPLPFSVAPDITCGKNAIPMIPGIADNVKHESRDSLCSYLSFGHIASSLSRRASNLAKIANVNLQGHGMTKIINALDKALIHGDTREAYTCLFDQLSDAAIDESWIAEVNPCLRSSLKWIGAVKFSVVYAVFSLCEWATCDFRDIRNFMPQNVKLTGKKDACQVYVAVLLLKYWMEDTRSSFSSKKNSSSGHSKTPPINNDLSGEANIENIYGSGIFSNSFDEKSSSTYFESPGPLHDIIVCWLDQHESGKGERFKRIQVLIMEFIRHGIFYPQAYVRQLIVSGIMDRTGTSSEFDTQRRHSQILKQLPGAYIFDTLEESKIIDAEFLSEVVNIYSNERNLALHGLCNLHSVHMYTGQHDLLNAFPENLRKVAVHRDHSTSSILENSENFSADFIDIPSKRVKSRLQVNYLKIAICSLFHLPRSCAFIETASNDTKERLKISPVSSDSKLDSAEGRFDIEECKRSKKQRKINEKFSHIHDYSSNQSDDDDTWWVKKGTKSLDLFKTEQSHKSVKSTSRKPKSVRKTQSLAQLQALRIESSQKASTSHACDNKSNCSHHKSTDDGEVLKLVGGVAKTIDVNVIGKSFRKLRCLQKRSVVIWLLKCVKSLIEGNVSITNKLIEEKGFPLKFGEDEFSSLVYLLDISSDLYSLVNFLLWLFPMVVKGTSDVTLGRNSIGLPRNKENNICNIEESVILSSLQRYENVIVATDLIPELLSAIMHRSVISVASVAYAQNLLKKYGTAANVVKWEKCFKATADARIFAEFESGKSLDADMRYTFRIPAGVENIDDFFRQKISGKISRAGQIMKDMFLRKFEEQFYGKARKFFSSTTDIKWEDVYQIAQKIVSMLLECLRQNGSTSQETDPSLVAAAVSAIVCNIELSVGNLPDFISASNHQSYSSAANSFSWIRSIVNVHIACLSLLKEALGERFSRVLEITLAVEASSVIFPSFAYRKAPRGQFHLSPEIHDISSNISNDITNNSSRLFPGRASMVAASVSALIVGAIIHGVLSLERMITVFRLNKELDILQLVSSSKYNSNDISRSAINLKASNSIEVNLHWFQLLVGNCRSLFDGLIVDILGEPHILALSRMQRMLPLHLAFPPVYSIFTMVIWRPYIINHNDESNEDIQLYKCLSIAIDDTIKHNPFRDLCLRDTHALYELLSSNSNDCDFGVMLEQQLQLSPEKKSKAMAFVPLRARYFLNAILDLSMPSFSEMKENVSLASEHGESVHGENNQLVHLLDTLQPAKFHWQWVELRLLLNEQAVMAMEAHGLSVVDALRSLSTTSENDALSENENAFTDIVLTRLLVRPDAASLYSELFQLLGRSLEEKLLLHAKWLLAGNDVLLGRKSIRQRLVNLAQSKGLSTKSQFWKPWGWACSNSEIYGIKTKKRKLEAISLEEGEFVDEGTDAKKMGKSTMQTFGVVGINSRQLYMTDRALANLVLPCIDRSSNKTRTAFAIDLIKQMNNIYRHINTFTQGVHKNSTGILSSSGDGSGNKGNSRKGISGGSPGMVRRPSGTKDSTPPPAAALKASIWLRLQFLLRLLPTICPEREASNRSLRNSLASSLLHLLGTQLVYEDVDVSFMPVQKTSPRKEMELLVESTITNTLDISGESLFDIILSVLYGLLSGCKPSWLKSRSTSKMNFKPSRDFLVNDREFIEDLQAHLDSMRVPASIQRRLQCALPMLPRCRCSVLSCHPPVVSSESCFSLQPAMLTPGFSQANPKSPQRPVSNTRTATNISGRSKPLPPQDNNEMQIDPWLLLEDGVVSASASSSNSNSNSFAGGIGNDQSNLKASFWLKGTVRVRRTDLTYIGPMDDGS
Length2236
PositionKinase
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index45.61
Isoelectric point8.82
Molecular weight250189.55
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.90|      30|     623|     624|     786|       1
---------------------------------------------------------------------------
  585-  616 (46.09/79.97)	QVYVAVLLLKYWMEdtRSSFSSKKNSSSGHSK
  696-  725 (52.82/102.23)	QAYVRQLIVSGIMD..RTGTSSEFDTQRRHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.87|      26|     260|    1947|    1972|       2
---------------------------------------------------------------------------
 1947- 1972 (48.41/26.23)	LKASIWLRLQFLLRL..LPTICPEREAS
 2090- 2106 (20.84/ 7.43)	..ASIQRRLQCALPM..LPR.C......
 2209- 2236 (40.62/20.92)	LKASFWLKGTVRVRRtdLTYIGPMDDGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.51|      44|     260|     185|     238|       3
---------------------------------------------------------------------------
  185-  236 (62.17/56.94)	LADNVPHgyRKKGLLEVIIRHNVPILRATWfikvTYLnqIRPTTGGISSGTL
  282-  325 (81.34/43.63)	LAPCSSH..RRNDLLPSVTNAGDPSLQVKW....DYV..MRLLIWNCSEGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.38|      10|     104|     384|     393|       4
---------------------------------------------------------------------------
  384-  393 (19.49/14.66)	QG.GMDTVANA
  487-  497 (14.88/ 9.08)	QGhGMTKIINA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     204.67|      57|     623|    1342|    1405|       5
---------------------------------------------------------------------------
  732-  762 (32.31/10.74)	...............GAYIFDTLEESKIIDAEF.LS.EVVNI.....YSNE.RN.........
 1348- 1404 (96.05/57.55)	ERFSRVLEITLAVEASSVIFPSFAYRKAPRGQFHLSPEIHDI.....SSNI.SNDITNNSSRL
 1407- 1467 (76.30/32.10)	GRASMVAASVSALIVGAIIHGVLSLERMIT.VFRLNKEL.DIlqlvsSSKYnSNDISRSAINL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.05|      37|     621|     624|     667|      13
---------------------------------------------------------------------------
  631-  667 (68.16/44.79)	ENIY..GSGIFSNSFD..EKSSSTYFESPGPL....HDIIVCWLD
 1256- 1300 (46.88/22.04)	EDVYqiAQKIVSMLLEclRQNGSTSQETDPSLvaaaVSAIVCNIE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04455 with Med12 domain of Kingdom Viridiplantae
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