<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04455

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYSSSNRGGGFSNNAVGGTTSLRDRVDPSLSSNFSVNSRKLSQLLPYKLKCEKESLSFRLGPPDFYPQAPNCPEETLTREYLLSGYKETVEGIEESQEITLTHIRHHSKPVILKCKEAIKKHLRTINESRAQKRKAGQVYGVPLSGKLLLKPGIFPEQKQVGEDARKKWIEGLSQRHKHLRLLADNVPHGYRKKGLLEVIIRHNVPILRATWFIKVTYLNQIRPTTGGISSGTLDKSQFVRTESWTKDLIEYMQHLLDKFLTKDGISPQRGSRDQTSQILAPCSSHRRNDLLPSVTNAGDPSLQVKWDYVMRLLIWNCSEGLLFPSLILEWVLSQLQAKDSVDVLEFLLPIIVDLAESVSLSQIYIRLFADIAVRFLQNLCQGGMDTVANAKKPHLASPLVELLRYLLLSTPDAFVGLDCFPLPFSVAPDITCGKNAIPMIPGIADNVKHESRDSLCSYLSFGHIASSLSRRASNLAKIANVNLQGHGMTKIINALDKALIHGDTREAYTCLFDQLSDAAIDESWIAEVNPCLRSSLKWIGAVKFSVVYAVFSLCEWATCDFRDIRNFMPQNVKLTGKKDACQVYVAVLLLKYWMEDTRSSFSSKKNSSSGHSKTPPINNDLSGEANIENIYGSGIFSNSFDEKSSSTYFESPGPLHDIIVCWLDQHESGKGERFKRIQVLIMEFIRHGIFYPQAYVRQLIVSGIMDRTGTSSEFDTQRRHSQILKQLPGAYIFDTLEESKIIDAEFLSEVVNIYSNERNLALHGLCNLHSVHMYTGQHDLLNAFPENLRKVAVHRDHSTSSILENSENFSADFIDIPSKRVKSRLQVNYLKIAICSLFHLPRSCAFIETASNDTKERLKISPVSSDSKLDSAEGRFDIEECKRSKKQRKINEKFSHIHDYSSNQSDDDDTWWVKKGTKSLDLFKTEQSHKSVKSTSRKPKSVRKTQSLAQLQALRIESSQKASTSHACDNKSNCSHHKSTDDGEVLKLVGGVAKTIDVNVIGKSFRKLRCLQKRSVVIWLLKCVKSLIEGNVSITNKLIEEKGFPLKFGEDEFSSLVYLLDISSDLYSLVNFLLWLFPMVVKGTSDVTLGRNSIGLPRNKENNICNIEESVILSSLQRYENVIVATDLIPELLSAIMHRSVISVASVAYAQNLLKKYGTAANVVKWEKCFKATADARIFAEFESGKSLDADMRYTFRIPAGVENIDDFFRQKISGKISRAGQIMKDMFLRKFEEQFYGKARKFFSSTTDIKWEDVYQIAQKIVSMLLECLRQNGSTSQETDPSLVAAAVSAIVCNIELSVGNLPDFISASNHQSYSSAANSFSWIRSIVNVHIACLSLLKEALGERFSRVLEITLAVEASSVIFPSFAYRKAPRGQFHLSPEIHDISSNISNDITNNSSRLFPGRASMVAASVSALIVGAIIHGVLSLERMITVFRLNKELDILQLVSSSKYNSNDISRSAINLKASNSIEVNLHWFQLLVGNCRSLFDGLIVDILGEPHILALSRMQRMLPLHLAFPPVYSIFTMVIWRPYIINHNDESNEDIQLYKCLSIAIDDTIKHNPFRDLCLRDTHALYELLSSNSNDCDFGVMLEQQLQLSPEKKSKAMAFVPLRARYFLNAILDLSMPSFSEMKENVSLASEHGESVHGENNQLVHLLDTLQPAKFHWQWVELRLLLNEQAVMAMEAHGLSVVDALRSLSTTSENDALSENENAFTDIVLTRLLVRPDAASLYSELFQLLGRSLEEKLLLHAKWLLAGNDVLLGRKSIRQRLVNLAQSKGLSTKSQFWKPWGWACSNSEIYGIKTKKRKLEAISLEEGEFVDEGTDAKKMGKSTMQTFGVVGINSRQLYMTDRALANLVLPCIDRSSNKTRTAFAIDLIKQMNNIYRHINTFTQGVHKNSTGILSSSGDGSGNKGNSRKGISGGSPGMVRRPSGTKDSTPPPAAALKASIWLRLQFLLRLLPTICPEREASNRSLRNSLASSLLHLLGTQLVYEDVDVSFMPVQKTSPRKEMELLVESTITNTLDISGESLFDIILSVLYGLLSGCKPSWLKSRSTSKMNFKPSRDFLVNDREFIEDLQAHLDSMRVPASIQRRLQCALPMLPRCRCSVLSCHPPVVSSESCFSLQPAMLTPGFSQANPKSPQRPVSNTRTATNISGRSKPLPPQDNNEMQIDPWLLLEDGVVSASASSSNSNSNSFAGGIGNDQSNLKASFWLKGTVRVRRTDLTYIGPMDDGS
Length2236
PositionKinase
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index45.61
Isoelectric point8.82
Molecular weight250189.55
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.90|      30|     623|     624|     786|       1
---------------------------------------------------------------------------
  585-  616 (46.09/79.97)	QVYVAVLLLKYWMEdtRSSFSSKKNSSSGHSK
  696-  725 (52.82/102.23)	QAYVRQLIVSGIMD..RTGTSSEFDTQRRHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.87|      26|     260|    1947|    1972|       2
---------------------------------------------------------------------------
 1947- 1972 (48.41/26.23)	LKASIWLRLQFLLRL..LPTICPEREAS
 2090- 2106 (20.84/ 7.43)	..ASIQRRLQCALPM..LPR.C......
 2209- 2236 (40.62/20.92)	LKASFWLKGTVRVRRtdLTYIGPMDDGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.51|      44|     260|     185|     238|       3
---------------------------------------------------------------------------
  185-  236 (62.17/56.94)	LADNVPHgyRKKGLLEVIIRHNVPILRATWfikvTYLnqIRPTTGGISSGTL
  282-  325 (81.34/43.63)	LAPCSSH..RRNDLLPSVTNAGDPSLQVKW....DYV..MRLLIWNCSEGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.38|      10|     104|     384|     393|       4
---------------------------------------------------------------------------
  384-  393 (19.49/14.66)	QG.GMDTVANA
  487-  497 (14.88/ 9.08)	QGhGMTKIINA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     204.67|      57|     623|    1342|    1405|       5
---------------------------------------------------------------------------
  732-  762 (32.31/10.74)	...............GAYIFDTLEESKIIDAEF.LS.EVVNI.....YSNE.RN.........
 1348- 1404 (96.05/57.55)	ERFSRVLEITLAVEASSVIFPSFAYRKAPRGQFHLSPEIHDI.....SSNI.SNDITNNSSRL
 1407- 1467 (76.30/32.10)	GRASMVAASVSALIVGAIIHGVLSLERMIT.VFRLNKEL.DIlqlvsSSKYnSNDISRSAINL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.05|      37|     621|     624|     667|      13
---------------------------------------------------------------------------
  631-  667 (68.16/44.79)	ENIY..GSGIFSNSFD..EKSSSTYFESPGPL....HDIIVCWLD
 1256- 1300 (46.88/22.04)	EDVYqiAQKIVSMLLEclRQNGSTSQETDPSLvaaaVSAIVCNIE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04455 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GFSQANPKSPQRPVSNTRTATNISGRSKPLPPQDNNEMQ
2) STGILSSSGDGSGNKGNSRKGISGGSPGMVRRPSGTKDSTP
2134
1901
2172
1941










Molecular Recognition Features






MoRF SequenceStartStop




1) YIGPM
2228
2232