<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04443

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDHPNKRETPPRSSPSHQFRHARAVLIDLFNLYLGVSRTLRPKIEDADEIRESPKNLQKRVTAPNVNIIPRNEQFLLDFEKIREQFQDQDQLRMNLDSVLVSFVIQCADHAPRAEFMLYALRVLCSINYVNWDTFLLLLLSTVFTLETSGGQEGTSQSMLPNLQSTNLVISDGMITLPSSGISNSTNFNGSNIAFTPHLSSNNSIVFPTHPTIEHPDGVRLLPIKENHIRHISCKIILIGLEFNLKPFTHAEIFSHMLTWLSNWDKNQILDEIQNRKEWQPRGPLNQKLHLCLDVVWMLVDEERCRVPFYEFLRSGLQFLGNSLDDVSLFPLILKIHRRRDMVALYMQMLDQNLHCPSFGTHRILSHTHASISGEAMTNLRHSPITYPSVLGEPLYGEDIAASIPKGSMDWERAMRCLRHALRTAPSPDWWRRVLIVAPCYRQHPQQVSYPGAVFSSAMVCEAVIDRTIELLNLVYSDIDCWNEWLSFSDIFYFLIKSACIDFIDFINKLSSRVMKDGRQIPRTNHVTWMLAQIIRLEIAVSSLSVDVRNRSATDSRNVETARKMISFHKEDKNSDKNNDTAHSTLLDFVSSSQALRFWSFNHLVRDYLSSDQLQKGKKIDDWWKQVTKEKTLDFMNLDDQSLGMLWVLSFTMAQPVMDAVVNWLKSAGVSELAVTQNVQSNERIMIMNETCPLPMKLLSGLSINLCWKLYLNLEEIIFFGQVIPSIAMVETYVRLLLVAPYSIFRPHFTSLTSKVPNLLTKTWVLLLLLEILNYRLFSLYRYYGKSTALLCDVTKIISMIKGKCGEHRTFRLAENLCINLILSIRDFFVVKKDLKGSSDFTETLNRITIVSLAITIKTRGIADVDHMLRLQPVLEQIMSTCQHTWSDKTMRHFPQLIRDFLIGRMDRRAHTIQTWEQAEPTVLKQCTQLLSPSGGDPKYVRIYVDHSFPEHRLYLCSGAWILMGGHPENINSANLACVLKELSPEEVTKNIYTMVDVLLHHIQIELQHGHTLQDLLLKVNTNLASLVLQHELLPLDILLLALIDRDDDPYALRIVLNMLERQELQQKIKIFCSIRGSPDHWLNSGVSQRIEVQKALGNHLSSKDRYPTFFDDSPTRLLPVIPLIVYRLIENDATDAAVRVLAAYSSFLIHHPLRFSFVRDILAYFYGHLPNNLILRLLNVLDISKIPFSESFPQHVSSSNPVLCPPPEYFINLLLGLVNNVIPSITSKSKPGTTGGTSSGFSREPPVKTQSSSQFGSPSSDGRRPFYQNQDPGTYTQFVLETAVIEILSLPVTTAQIVSSLVQIMEHIQSTLIRFNNGLLGFSGSGQSNGLPTSPSGASAESLGTPRSNNSSQGINASGLMSKVFIHETSRVIKECWWLADGKRSAGELETSVGYALLDPSCASQENTSTAIGNTVALLHSFFSNLPQEWLESTQTLIKNFRPVTSVAILRIIFRIIGPLMPRLGFVRPVFLKIVHLLFNCMSDIFGKQTSSSVEASEITDIIDFLHHIVHYEGQGGGPVQSNSKPKSETLKLCGKAIEMLRPDIRHLLSHLSTDPISSIYAATHPNLNQNLT
Length1574
PositionTail
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.08
Grand average of hydropathy-0.078
Instability index44.76
Isoelectric point7.21
Molecular weight178356.48
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04443
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.11|      17|      18|     410|     426|       1
---------------------------------------------------------------------------
  376-  388 (18.20/ 6.84)	....AMTNLRHSPITYP
  410-  426 (33.81/18.71)	DWERAMRCLRHALRTAP
  429-  445 (33.11/18.17)	DWWRRVLIVAPCYRQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.56|      15|      15|    1013|    1027|       2
---------------------------------------------------------------------------
 1013- 1027 (23.38/12.93)	LQDLLLKVNTNLASL
 1029- 1043 (24.18/13.64)	LQHELLPLDILLLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.15|      44|     127|    1268|    1315|       5
---------------------------------------------------------------------------
 1268- 1315 (64.65/56.13)	YQNQDPGTYTQFVLETAVIEILSLpvtTAQIVSSLVQ.IMEHIQsTLIR
 1396- 1440 (72.50/48.90)	YALLDPSCASQENTSTAIGNTVAL...LHSFFSNLPQeWLESTQ.TLIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.56|      49|     306|    1135|    1197|       8
---------------------------------------------------------------------------
 1148- 1197 (83.97/64.98)	FLIHHPL..RFSFVRDILAYFYgHLPNNLILRLLNVLDISKIPFSE.....SFPQHV
 1455- 1510 (76.59/36.01)	FRIIGPLmpRLGFVRPVFLKIV.HLLFNCMSDIFGKQTSSSVEASEitdiiDFLHHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.33|      12|      15|     960|     971|       9
---------------------------------------------------------------------------
  960-  971 (23.93/19.40)	AWILMGGHPENI
  977-  988 (20.41/15.17)	ACVLKELSPEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.33|      30|    1078|     123|     155|      10
---------------------------------------------------------------------------
  123-  155 (47.36/36.88)	VLCS.INY.VNwdtFLLLLLSTVFTLETSGGQEGT
 1203- 1234 (45.97/26.50)	VLCPpPEYfIN...LLLGLVNNVIPSITSKSKPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.82|      14|     231|     481|     494|      11
---------------------------------------------------------------------------
  481-  494 (30.92/18.80)	CWNEWLSFSDIFYF
  707-  720 (27.90/16.25)	CWKLYLNLEEIIFF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04443 with Med23 domain of Kingdom Viridiplantae
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