<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04443

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDHPNKRETPPRSSPSHQFRHARAVLIDLFNLYLGVSRTLRPKIEDADEIRESPKNLQKRVTAPNVNIIPRNEQFLLDFEKIREQFQDQDQLRMNLDSVLVSFVIQCADHAPRAEFMLYALRVLCSINYVNWDTFLLLLLSTVFTLETSGGQEGTSQSMLPNLQSTNLVISDGMITLPSSGISNSTNFNGSNIAFTPHLSSNNSIVFPTHPTIEHPDGVRLLPIKENHIRHISCKIILIGLEFNLKPFTHAEIFSHMLTWLSNWDKNQILDEIQNRKEWQPRGPLNQKLHLCLDVVWMLVDEERCRVPFYEFLRSGLQFLGNSLDDVSLFPLILKIHRRRDMVALYMQMLDQNLHCPSFGTHRILSHTHASISGEAMTNLRHSPITYPSVLGEPLYGEDIAASIPKGSMDWERAMRCLRHALRTAPSPDWWRRVLIVAPCYRQHPQQVSYPGAVFSSAMVCEAVIDRTIELLNLVYSDIDCWNEWLSFSDIFYFLIKSACIDFIDFINKLSSRVMKDGRQIPRTNHVTWMLAQIIRLEIAVSSLSVDVRNRSATDSRNVETARKMISFHKEDKNSDKNNDTAHSTLLDFVSSSQALRFWSFNHLVRDYLSSDQLQKGKKIDDWWKQVTKEKTLDFMNLDDQSLGMLWVLSFTMAQPVMDAVVNWLKSAGVSELAVTQNVQSNERIMIMNETCPLPMKLLSGLSINLCWKLYLNLEEIIFFGQVIPSIAMVETYVRLLLVAPYSIFRPHFTSLTSKVPNLLTKTWVLLLLLEILNYRLFSLYRYYGKSTALLCDVTKIISMIKGKCGEHRTFRLAENLCINLILSIRDFFVVKKDLKGSSDFTETLNRITIVSLAITIKTRGIADVDHMLRLQPVLEQIMSTCQHTWSDKTMRHFPQLIRDFLIGRMDRRAHTIQTWEQAEPTVLKQCTQLLSPSGGDPKYVRIYVDHSFPEHRLYLCSGAWILMGGHPENINSANLACVLKELSPEEVTKNIYTMVDVLLHHIQIELQHGHTLQDLLLKVNTNLASLVLQHELLPLDILLLALIDRDDDPYALRIVLNMLERQELQQKIKIFCSIRGSPDHWLNSGVSQRIEVQKALGNHLSSKDRYPTFFDDSPTRLLPVIPLIVYRLIENDATDAAVRVLAAYSSFLIHHPLRFSFVRDILAYFYGHLPNNLILRLLNVLDISKIPFSESFPQHVSSSNPVLCPPPEYFINLLLGLVNNVIPSITSKSKPGTTGGTSSGFSREPPVKTQSSSQFGSPSSDGRRPFYQNQDPGTYTQFVLETAVIEILSLPVTTAQIVSSLVQIMEHIQSTLIRFNNGLLGFSGSGQSNGLPTSPSGASAESLGTPRSNNSSQGINASGLMSKVFIHETSRVIKECWWLADGKRSAGELETSVGYALLDPSCASQENTSTAIGNTVALLHSFFSNLPQEWLESTQTLIKNFRPVTSVAILRIIFRIIGPLMPRLGFVRPVFLKIVHLLFNCMSDIFGKQTSSSVEASEITDIIDFLHHIVHYEGQGGGPVQSNSKPKSETLKLCGKAIEMLRPDIRHLLSHLSTDPISSIYAATHPNLNQNLT
Length1574
PositionTail
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.08
Grand average of hydropathy-0.078
Instability index44.76
Isoelectric point7.21
Molecular weight178356.48
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04443
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.11|      17|      18|     410|     426|       1
---------------------------------------------------------------------------
  376-  388 (18.20/ 6.84)	....AMTNLRHSPITYP
  410-  426 (33.81/18.71)	DWERAMRCLRHALRTAP
  429-  445 (33.11/18.17)	DWWRRVLIVAPCYRQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.56|      15|      15|    1013|    1027|       2
---------------------------------------------------------------------------
 1013- 1027 (23.38/12.93)	LQDLLLKVNTNLASL
 1029- 1043 (24.18/13.64)	LQHELLPLDILLLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.15|      44|     127|    1268|    1315|       5
---------------------------------------------------------------------------
 1268- 1315 (64.65/56.13)	YQNQDPGTYTQFVLETAVIEILSLpvtTAQIVSSLVQ.IMEHIQsTLIR
 1396- 1440 (72.50/48.90)	YALLDPSCASQENTSTAIGNTVAL...LHSFFSNLPQeWLESTQ.TLIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.56|      49|     306|    1135|    1197|       8
---------------------------------------------------------------------------
 1148- 1197 (83.97/64.98)	FLIHHPL..RFSFVRDILAYFYgHLPNNLILRLLNVLDISKIPFSE.....SFPQHV
 1455- 1510 (76.59/36.01)	FRIIGPLmpRLGFVRPVFLKIV.HLLFNCMSDIFGKQTSSSVEASEitdiiDFLHHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.33|      12|      15|     960|     971|       9
---------------------------------------------------------------------------
  960-  971 (23.93/19.40)	AWILMGGHPENI
  977-  988 (20.41/15.17)	ACVLKELSPEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.33|      30|    1078|     123|     155|      10
---------------------------------------------------------------------------
  123-  155 (47.36/36.88)	VLCS.INY.VNwdtFLLLLLSTVFTLETSGGQEGT
 1203- 1234 (45.97/26.50)	VLCPpPEYfIN...LLLGLVNNVIPSITSKSKPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.82|      14|     231|     481|     494|      11
---------------------------------------------------------------------------
  481-  494 (30.92/18.80)	CWNEWLSFSDIFYF
  707-  720 (27.90/16.25)	CWKLYLNLEEIIFF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04443 with Med23 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTTGGTSSGFSREPPVKTQSSSQFGSPSSDGRRPFYQ
1233
1269










Molecular Recognition Features






MoRF SequenceStartStop




NANANA