<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04437

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMEKSLSEKQLIVVVEGTASMGPYWKTIISDYLEKIIRIFCASKIPRQNLSDECLPELGLVVFNVHGPYSPFIVQQSGLTKDVDLFLRYLTTLPMSGGSFSEGAIAEGLAESLMMFSQNPDCHKHCILVAASNPYPFPTPISKPVIQNAENHDKYEVQIETCLSDAETVAKSFSKSFFSLSIISPRQLPKLQAIYNAGKHDSQSADPVVNNEKNPYFLILLSENFVEGCIALALPVVVNKQTDQRIVMMDGSMGRAAAHVQSISMSPQTHSTENEAIANQTILSEGNNIASIVKNMNPQNAEPSLLASSGFPHTPSIINSITQGGQIPSTSSASPPSLDLQEFRHIVNPSPQSLHPVGPPAHSNILNNLSRTHQVLASASITGGTSIELQTNGEFSTVIPGPNIITDVIVSSSVSRSGTVSKNVQTTQNTVTGSLTYSNSNLSPNLSVSSPLSNLQDNVGMNQSLPNIGQANIISGISGILQQSQHGLNSLAVNKPLQICTSGVQQLRPKYDKIWELPHTRLQ
Length522
PositionUnknown
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.05
Grand average of hydropathy-0.140
Instability index53.71
Isoelectric point5.96
Molecular weight56258.08
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04437
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     388.75|     127|     152|     171|     320|       1
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   27-  168 (193.68/135.35)	IISD.YLEKIIRIFCASKIPRQNlSDeclPelglVVFNVHGPYSPFIVQQSGLTKDVDLFLRYLTT......LPMSGGSFSEGAI.AEGLAESLMMFS.QNPDCHKHCILVAASNpypFPTPISKPVIQNAENhdkyEVQIETCLSDAETV
  181-  316 (195.07/151.34)	IISPrQLPKLQAIYNAGKHDSQS.AD...P....VVNNEKNPYFLILLSENFVEGCIALALPVVVNkqtdqrIVMMDGSMGRAAAhVQSISMSPQTHStENEAIANQTILSEGNN...IASIVKNMNPQNAEP....SLLASSGFPHTPSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.96|      39|      48|     317|     356|       2
---------------------------------------------------------------------------
  317-  340 (30.52/11.51)	........................INSITQGGQI.PSTSSASPPSLDLQ
  341-  389 (51.36/28.36)	EFRHIVnPSPQSLHPVgppahsniLNNLSRTHQVlASASITGGTSIELQ
  393-  419 (27.08/ 9.66)	EFSTVI.PGPNIITDV......ivSSSVSRSGTV...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.41|      19|      42|     445|     465|       3
---------------------------------------------------------------------------
  445-  465 (28.47/25.85)	LSVSSPLSNLQDnvGMNQSLP
  490-  508 (33.94/23.29)	LAVNKPLQICTS..GVQQLRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04437 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IINSITQGGQIPSTSSASPPSLDLQEFRHIVNPSPQSLHPVGPPAHSNILNNL
316
368










Molecular Recognition Features






MoRF SequenceStartStop




NANANA