<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04432

Description Luminal-binding protein 4
SequenceMELDMKTRRSLVFFGMVLAGCLFAFSNAAEEAPKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVAFTDGERLIGEAAKNQAAVNHQRTFFDVKRLIGRKFEDKEVQKDMKLVPYKIVNKDGKPYLQVKMKDGETKVFSPEEISAMILTKMKETAEEFLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVVRIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLATNGDTHLGGEDFDQRIMEYFIKLIKKKHGKDISKDNRALGKLRREAERAKRALSNQHQIRVEIEALYDGLDFSEPLTRARFEELNNDLFRKTMGPVKKAMADAGLEKSQIDEIVLVGGSTRIPKVQQLLKDYFGGKEPNKGVNPDEAVAFGAAVQGSILSGEGGEETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTVVSIQVFEGERSLTKDCRQLGKFDLTGLAPAPRGTPQIEVTFEVDANGILNVRAEDKASGKSEKITITNDKGRLTQEEIERMVREAEEFADEDKKVKDKIDSRNALETYVYNMKNTINDKDKLAEKIESDDKEKIEDAIKEALEWLDENQSAEKEDYDEKLKEVEAVCNPIITAVYQKSGGASADGASAGDEDEDEDHDEL
Length669
PositionUnknown
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.06
Grand average of hydropathy-0.465
Instability index30.86
Isoelectric point5.03
Molecular weight73968.92
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum chaperone complex	GO:0034663	IBA:GO_Central
endoplasmic reticulum lumen	GO:0005788	IBA:GO_Central
membrane	GO:0016020	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central

GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
endoplasmic reticulum unfolded protein response	GO:0030968	IBA:GO_Central
protein refolding	GO:0042026	IBA:GO_Central
ubiquitin-dependent ERAD pathway	GO:0030433	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04432
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.46|      26|      26|     582|     607|       1
---------------------------------------------------------------------------
  532-  551 (23.40/10.48)	KITItN..DKGRLT.......Q.EEIERMV
  555-  581 (31.15/16.35)	EEFA.D..EDKKVKDKIDSRNAlETYVYNM
  582-  607 (40.89/23.73)	KNTI.N..DKDKLAEKIESDDK.EKIEDAI
  608-  635 (31.03/16.26)	KEAL.EwlDENQSAEKEDYDEK.LKEVEAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.30|      11|      26|     232|     242|       3
---------------------------------------------------------------------------
  232-  242 (20.46/10.10)	LGGGTFDVSIL
  260-  270 (21.85/11.22)	LGGEDFDQRIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.97|      81|     193|     130|     231|       4
---------------------------------------------------------------------------
  130-  231 (107.48/123.84)	DG....KPYLQVKMKDGETKVFSpeeiSAMILTKmKETAEEFLGKKIKDAVVTVPA.............YFNDaqRQATKDagviaglnvvriINePTaAAIAYG.......LDKKGGE..KNILVFD
  321-  427 (115.50/78.17)	DGldfsEPLTRARFEELNNDLFR....KTMGPVK.KAMADAGLEKSQIDEIVLVGGstripkvqqllkdYFGG..KEPNKG............VN.PD.EAVAFGaavqgsiLSGEGGEetKDILLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.59|      35|     193|     282|     318|       5
---------------------------------------------------------------------------
  283-  318 (52.60/40.10)	KDISKDNRALGKLRREA.ERAKRAlSNQHQIRVEIEA
  479-  514 (56.98/33.76)	RSLTKDCRQLGKFDLTGlAPAPRG.TPQIEVTFEVDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.96|      12|      15|     441|     452|       7
---------------------------------------------------------------------------
  441-  452 (20.21/14.27)	VMTKLIPRNTVI
  459-  470 (20.75/14.83)	VFTTYQDQQTVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04432 with Med37 domain of Kingdom Viridiplantae
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