<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04422

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMVSLISGSPQAFETFKEPDDGRQRLLIELEFVQCLANPIYIHHLAQNQYFEDEAFVRYLKYLQYWQKPQYITLIMYPHCLYFLELLQNERFRSAMAHPNYKELVHQQQFYFWKHHKKNRLNYILTSNHSESAPKPPVVPPSPAAPATVPSESVPAKSVPAKSVSAESIPTESIPAESVPAESVPAESIPAESVPRPAHSPMQMQMQMQMPELIDLTDIGDEEMSELSD
Length228
PositionMiddle
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.10
Grand average of hydropathy-0.423
Instability index64.87
Isoelectric point5.25
Molecular weight26069.37
Publications
PubMed=26814964

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364129
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04422
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.83|      19|      19|     151|     169|       1
---------------------------------------------------------------------------
  130-  149 (29.26/13.23)	ESAPKPPvVPPSPAAPATVP
  151-  169 (35.47/17.46)	ESVPAKS.VPAKSVSAESIP
  171-  189 (36.10/17.90)	ESIPAES.VPAESVPAESIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      13|      27|      29|      41|       2
---------------------------------------------------------------------------
   29-   41 (24.50/13.07)	LEFVQCLANPIYI
   59-   71 (25.98/14.19)	LKYLQYWQKPQYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.16|      17|      20|      84|     100|       3
---------------------------------------------------------------------------
   84-  100 (31.02/21.62)	ELLQNERFRSAMAHP....NY
  102-  122 (29.13/19.90)	ELVHQQQFYFWKHHKknrlNY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04422 with Med31 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SAPKPPVVPPSPAAPATVPSESVPAKSVPAKSVSAESIPTESIPAESVPAESVPAESIPAESVPRPAHSPMQMQMQMQMPELIDLTDIGDEEMSELSD
131
228










Molecular Recognition Features






MoRF SequenceStartStop




NANANA