<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04419

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMISESPEAFETFKDPDDGRQRLLIELEFVQCLANPIYIHHLAQNQYFEDEAFVRYLKYLQYWQKPQYITLIMYPHCLYFLELLQNESFRSAMAHPSYKELVHQQQFYFWKHHKKNRLNYILTSYHSESAPKPSVVPPSPAPPETVPAESTPAESVPAESIPAESVPRPSHSLMQMQMQMPELIDLTDIGDEEMS
Length194
PositionMiddle
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.12
Grand average of hydropathy-0.508
Instability index65.25
Isoelectric point5.10
Molecular weight22706.52
Publications
PubMed=26814964

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP04419
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.44|      13|      27|      26|      38|       1
---------------------------------------------------------------------------
   26-   38 (23.66/12.90)	LEFVQCLANPIYI
   56-   68 (24.57/13.62)	LKYLQYWQKPQYI
   86-   97 (16.21/ 6.93)	ESFRSAMAHPSY.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.10|      11|      34|     123|     133|       2
---------------------------------------------------------------------------
  123-  133 (21.88/14.66)	SYHSESAPKPS
  159-  169 (21.21/13.98)	SIPAESVPRPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04419 with Med31 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPSVVPPSPAPPETVPAESTPAESVPAESIPAESVPRPSHSLMQMQMQMPELIDLTDIGDEEMS
131
194










Molecular Recognition Features






MoRF SequenceStartStop




NANANA