<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04417

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSNTIPRPVIPVGAATVPTITPDADLVVATSSVVIDAEVIGDTTPPEDSVVDHPVKEGEGGDVGTVSGMDVVEGGGGGESGVDGVVEKREPDDCEMVEVEDDVARSLYESSSSSTSSPATVFRIRLKQTPSNLTHKMRVPGLCRNFSAVAWCGKLNIISCASETCARIPSSNANPPFWIPIYILNPERPTECAVFNITADSPRDSVQFMEWSPRSSPRALLIANFHGRATIWTQPSQSSPNLIRDGNFWEREHEWRQDLVVTTKWLSGITPYRCFPSNSTLSACSKSTFEEKFFCKQPQISGRWPNFLCVCSIFSSGSVQLHWSQWPPPQNGQSKWFSSSKGLLGAGPSGIMVADAIITDAGTMHVAGVPIVNPSTVVVWEVIPGPGNVLQTCAKINISSAIPSSLNNKCTGIASLAAYLFSWQDYLLSDGKEGKKSIDQDLHEAVSLHCSPVSNFSAYVSPELAPQSAASTTWGSGVTAVSFDPTRGGSVISVAIVEGQYMSPHDPDVGPSITNWRVQCWESSLKPVVLHPIFENPSSNVGGQPPMQTVWEKKFDKTIPPTDDFRSSQMPIPQATFDERNSSDSSIEKINRLIFDPYDLPSDVRMLAKIVYASHGGEVSVAFLRGSVHIFHGPEFIPVDSYQVNVGSTIAAPAFSSTSCCLASVWHDSKDRTTLKIFRVLPPATASVQAKLNSMTWERAISDRFWWSLLVGVDWWDVVGCIQSASEDGIVSLNSIIGVLDDDFHSLPSTQHRRYHGPNLEKIKCRLLEGTNAQDVRALVLDMQARLLLDMLGKGIESALVNPETLMAEPWLASNESLSAVEADKMAIDPLLATSIQGYVDAILDLASHFITRLRRYASFCRTLATHAVTSAGTGSTRNMVVSPPLTSASPSNQGGHSSGTNPSGNSQVQAWVQGAIAKINTSDGSPSTIPNPTSGPSSFMPISINTSTFPGTPAVRLIGDCHFLRRLCQLLLFCLIFRRKQSRIIANSQKTFDSNFPKAHAIAGLKVEESTTTFRSSLGDMQVGRPGQLPVGSKGPDDGTAVRSIRIGTGNAGQGYTSEEVRILFLILVDLCKRTAPLPHPFPSSQMEMSNISIRLHYIDGIYTVLPEIVEASLGPHMQNMPRPRGADAAGLLLRELELHPPSEEWHRRNMFGGPWSDSDDLGPSNDRPHMNPYIYSDSKSPGGLNSDVFRSQNTWPRKRRFSERDAAFGIKTSVGLGSYLGIMGSRRDVVTTLWKTGLQGIWYKCVRCLRQTSAFTEPSASNHNTNEVESWWISRWTNACPMCGGGWVRVV
Length1293
PositionTail
OrganismZostera marina (Eelgrass)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zosteraceae> Zostera.
Aromaticity0.08
Grand average of hydropathy-0.196
Instability index48.00
Isoelectric point6.06
Molecular weight140724.53
Publications
PubMed=26814964

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04417
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.39|      13|     110|     205|     218|       2
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  205-  218 (21.99/13.57)	SVQfMEWSPRSSPR
  318-  330 (29.40/14.05)	SVQ.LHWSQWPPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.12|      96|     340|     524|     625|       3
---------------------------------------------------------------------------
  524-  580 (75.33/37.92)	............................................................SLKPVVLH.PIFENPSSNVGGQPP.......MQTVWEKKFDKT.......IPPTDDFRSSQMPIPQATFdER
  581-  699 (123.30/73.28)	NSSDSSIEKINrlifDPYDLPSDVrMLAKIVYASHGGEVSVA......FLRgsvhifhgpEFIPVDSY.QV..NVGSTIAA.PAfsstsccLASVWHDSKDRTtlkifrvLPPAT..ASVQAKLNSMTW.ER
  921- 1015 (132.50/67.39)	NTSDGSPSTIP....NPTSGPSSF.MPISINTSTFPGTPAVRligdchFLR.........RLCQLLLFcLIFRRKQSRIIANS.............QKTFDSN.......FPKAHAIAGLKVEESTTTF...
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.03|      21|     527|     705|     726|       4
---------------------------------------------------------------------------
  705-  726 (39.33/29.33)	FWWSLLVGVdWWDVVGCIQSAS
 1235- 1255 (41.70/26.25)	LWKTGLQGI.WYKCVRCLRQTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.94|      35|     340|     457|     491|       5
---------------------------------------------------------------------------
  457-  491 (62.95/38.79)	SAYVSPE..LAPQSAASTTWGSGVTA..VSFDPTRGGSV
  798-  836 (50.99/29.92)	SALVNPEtlMAEPWLASNESLSAVEAdkMAIDPLLATSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.88|      14|      15|      55|      68|       6
---------------------------------------------------------------------------
   55-   68 (25.59/11.62)	VKEGEGGDVGTVSG
   71-   84 (26.29/12.11)	VVEGGGGGESGVDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.84|      44|     527|     345|     396|       7
---------------------------------------------------------------------------
  345-  396 (68.48/43.99)	GAGPSGIMVADAIITDAGTM....HVAGVPIVNPSTVVVWevIPGpgnvlqTCAKI
  873-  920 (73.37/32.72)	GTGSTRNMVVSPPLTSASPSnqggHSSGTNPSGNSQVQAW..VQG......AIAKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04417 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IDAEVIGDTTPPEDSVVDHPVKEGEGGDVGTVSGMDVVEGGGGGESGVDGVVEKREPDDCEMVEVED
35
101










Molecular Recognition Features






MoRF SequenceStartStop




NANANA