<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04401

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNVRVIDGFSNIYWRIYTEEPNIATLSGDSPTNGFTILKHLSRLKDLELRLRNLDCLVSSYPRRLGLWIFSATPDFESLGPLCSNGTSDDPSKLFVGSATLKVSASGSVTSKELVKNLSAEPVIAATNSQGVQRRQNGPNQARRTDGHGSSAAIYASFISAVTGALSLQLIRCNNAIPLGLRTLFTNVAEDYYDNPRIDNDNPAAVPSLTTLQIQLTSVGKLTVSLQTISQPGILRLCGPYDTSVEVHKAHPGCDLWLSPSGSIARLVATHSDFQNASSGYTTANPPSTSNLEEWKALVIEWLGNYGLPLISSEEEPWVEVEVWEPFYSRLAGETWRQNEEGASVLPLKRILWPARYCFTRKKPTSLAPFLGIDATFPVIDEPLGFAEKWFGMGQLEDGETESKPTSRPEPETKDQGTPLSRSDLPEGIESLSRASEYPDLQASSLVYPTPPDGAFPVGPNAPPASDAAAEDLDSRHLTNRTLAKVKAKEGASARERSDHDVLMSFGPSPGLIVGSGLYDTNDDDDLFGEMSRRDFGSKGITDADFSFFDDPDFNHLNGDVNEMDAGAQETSEIAIDAEESKPQPLPLQQPLTDNLPEQGDMTEQVDTTLAHPEEKMSSSQPADVPLSAGLPISSPINEDNQTISPPLSPIEVKKTLFAGPSEDSQLSVKKGHLQGHYNPVAFKENILNWDQKYGAEGKFRVTGAVVNNHTVLSSTTGDIPTIGLPRRNARTKNPHGLGRSIDKPRSPTSDLDQPIPSGSDFDSTSDTSDDTDGNLSNSDASVATFVTRKRKRARSYSGSTVNLPQEKPLARSEQSITTSRTDDLVFLGNFLSTFSDWSMTGYFSATQKQLGSVLVRKDVQVKVAQLLVDQVTQSCLDHKVDGNLGVSEFESKAYSLRTFLEDTAFMGEIERLDLNGFVSLQENSGFSPPSTAAMSRQSSQRKENGKSSMSKLDPPHLRIRRGKDYLEVLPPAISFWETFGLEPAYGSKDISAYCIHPQIAAEAANGFLERLGLLYSSCNLGQHTRASRSTGFDRGMCSWNIGAPGEFNYYYIMQSLKSICDKLVTALLKSPPTKDTVVVYIINPFNHAAALADICSAFWGLFQKYIDEAEKQQAGQANGLVLQIVPFHFIMSTESLVVPPQAQYLSLALEVYSRCPPKSLQPCLLNCAPPMLIAEPVPKAINFKLAPDRSSPLQEAKSLHIAYSRSYDQRWVSVSWTDNTGTLQRTMSYCLRFQNSNAARNILEVRNEIWAATKTIMEKTQARWKIIIVNTEPVDQDEVDTWASLVEQYNMTKPFLSDLTILYANTTPDLYLEPPPQPLPMSVFNPQISSTPVATPNPSGNAFSPDQSGAAPTPPSGGNAPTPTEIPPDAESECLLTDICDESWGVILSHCLNSSPHLTDYRPALASGYILRRKGPTDADGAFAMSVNLIYSQKPASSYENLLRDIIARYRDLATLARARGTRTVQQNTFPWHIATSIRAQELLSYVL
Length1497
PositionKinase
OrganismAspergillus udagawae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.377
Instability index51.76
Isoelectric point5.08
Molecular weight163896.76
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04401
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.39|      68|     277|    1100|    1173|       1
---------------------------------------------------------------------------
 1100- 1173 (108.39/66.13)	LADICSAFWGLFQKYIDEAEKQQAGQANGLvlqivPFHFIMSTESLVVPPQAQYLSLALeVYSRCPPKSLQPCL
 1385- 1452 (121.00/61.91)	LTDICDESWGVILSHCLNSSPHLTDYRPAL.....ASGYILRRKGPTDADGAFAMSVNL.IYSQKPASSYENLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.68|      12|     277|     240|     251|       2
---------------------------------------------------------------------------
  240-  251 (25.48/13.02)	PGILRLCGPYDT
  518-  529 (23.20/11.25)	PGLIVGSGLYDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.28|      45|     277|     598|     655|       3
---------------------------------------------------------------------------
  382-  441 (59.47/17.57)	DATFPViDEPLGFAEKWFGmgqledgetESKPTSRPepetKDQGTPLSrSDLPEGIESLS
  609-  653 (78.80/29.60)	DMTEQV.DTTLAHPEEKMS.........SSQPADVP....LSAGLPIS.SPINEDNQTIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      11|      15|    1344|    1354|       5
---------------------------------------------------------------------------
 1344- 1354 (23.30/12.28)	TPNPSGNAFSP
 1362- 1372 (22.57/11.63)	TPPSGGNAPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.91|      21|     274|     281|     318|       6
---------------------------------------------------------------------------
  294-  314 (40.14/43.61)	PPSTSNLEEWKALVIEWLGNY
 1196- 1216 (37.77/ 8.33)	PDRSSPLQEAKSLHIAYSRSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04401 with Med13 domain of Kingdom Fungi
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