<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04400

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNGTVGGPRHAPDTQTSSNADNLRNGSLHVNGAAKGAKDHNRDKESYTGRPGIDGHKALPELPHITQGFFPFSTLVNRSVQQCWNELSDLITELAAIQVSPHSSIPLLPVNGKSPGNQSPENLQKKLRILDFAHAKRAEFIKLLVLSQWSRQARDVSKLIDLQNFVRARHQAFVDALQRVGDMKRDLVQAQVANPDLQTALEILSKGRLESLADLGYKSSKLLTARGALRRLHKVNRIISARLALHDSIPRPFRTYRVHDGRVTFVVSGEFELDLSVGAESELSQFFFVDIRFLYSPSSNIPKGRMSNELDAKINDKLRDSGLTGCFNFLHGLVLTNKIHVLFKQAIELAKGLWSETLRVELLHRTLVIQYWALKPGPKSWVEIGIKSSNGNADRQGFGVPCLGLRWMRDGQDVDSSDIEFDTDDLSMECLLRSVVALHISHLLSSAYGILSEYSLFSTGTLSSQAILNVTEPGECQLSVQLTGSRHLRVSIEPMSGAVILSATPGLSERSESDASLDRSTIDDLVARVSRLRCIAAIEELESNVRILGFETVSLKGLRNDIRKVFPTNVLRFSLFWHPSWERNWVVAATSSIASDNWWVVQLRRSSEVAADFSGPDTSVPLCSGHSMSDTFLATIHQTHSSSFPDLGYCLSGMVAIYANVSYLADLQTVEFHPPLRTLKVESDLQIPDIFIRYQVSHLPPALQLVLPAGLRRKNFLKNTVRLVFHGIDRRKNIAIFVAYGNLVAPLTDLCTLVSKSDSSLVFKRGGSSFALRLLAPAGRPVIIQLFKSLQSLECTLSILDFLRQRRLTPQSLSLTHIAFAYGPRRDLSAIIGIGLSEVPSSAELDPVRILARTDPLLFLTLGIRFNHPNPHRRVQGSLAAILNHASNEAGLDFVTEILSFTLPLMRALEQITSNASRQESFRLQVIVRNAYTFLLHYTYQGFCFQLTTSQHMGQLTWVLRELSSPEARPGHDQLKARLRGTLYHSKGNGWKGLGNGVVADAEGVSNAIWALDGCFTGTQHNTWLLRENKSDQDYSTQPISEKQSQTGAPSQAGMANDTTMTANFINDKSLQRNPVASNAADVITID
Length1093
PositionTail
OrganismAspergillus udagawae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.141
Instability index46.34
Isoelectric point8.87
Molecular weight120994.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04400
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     344.76|      85|     178|     632|     717|       1
---------------------------------------------------------------------------
  161-  204 (31.01/14.37)	.....................................DVSKLIDLQNfvrARHQAFV..DALQRVGDMK...RDL.VQAQVAN........PDLQ.......
  205-  285 (87.73/55.86)	.....TALEILSKGRLESLADLGYK...SSKLLTARGA...LRRLHK...VN.......RIISARLALHdsIPRPFRTYRVHDgrvtfvVSGEFELDLSVGA
  311-  382 (83.76/53.25)	R.MSNELDAKINDKLRDS..GLTGCfnfLHGLV.LTNKIHVLFK.QA...IELAKGLwsETLRVE..LL..HRTLVIQYWA........LKP..........
  632-  717 (142.26/100.46)	HsMSDTFLATIHQTHSSSFPDLGYC...LSGMVAIYANVSYLADLQT...VEFHPPL..RTLKVESDLQ..IPDIFIRYQVSH......LPPALQLVLPAGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.70|      31|     667|     113|     143|       2
---------------------------------------------------------------------------
  113-  143 (54.19/36.54)	LLPVNGKSPGNQ...SPENLQKKLRILDFAHAKR
  780-  813 (47.39/30.95)	LLAPAGRPVIIQlfkSLQSLECTLSILDFLRQRR
  815-  831 (21.12/ 9.34)	...............TPQSL..SLTHIAFAYGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.44|      11|      63|     963|     973|       3
---------------------------------------------------------------------------
  963-  973 (21.14/15.17)	TWVLRELSSPE
 1029- 1039 (21.30/15.35)	TWLLRENKSDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.05|      11|     175|     547|     559|       4
---------------------------------------------------------------------------
  547-  558 (13.57/14.60)	LESNVRILgFET
  564-  574 (19.48/ 7.84)	LRNDIRKV.FPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04400 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMDNGTVGGPRHAPDTQTSSNADNLRNGSLHVNGAAKGAKDHNRDKESYTGRPGIDGHKA
2) RENKSDQDYSTQPISEKQSQTGAPSQAGMANDTTMTANFINDKSLQ
1
1033
64
1078










Molecular Recognition Features






MoRF SequenceStartStop




NANANA