<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04390

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGQPLHAVYSGTGRADLSQPLGQPDRQSEQPSMPVPQLQGRPPTLIDLTANDGDVLDREPPAKRLKIDVHAESVAGDGSPASAGAGESKTTPSTTTSKPLSLSWRARPVWSFQALLSEVSGSAEINVESAAGVVQDVKPPSPPSFTGPPWKFAPADTIASDSAGAQDGAPAKEVQTTPYHIETPSVAPVLGGEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQGHSMVTAPSTFKPPPRVTLTDNKREAWLRDLANPNVPLRKLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTTNVQQFLEGVITSCGVADWKMKMTYAVNLTARLFFEQLLDHDQYLGWFLASLEVAPFNSLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQLAIKSDSATSLRPLTERLSLHIRKLTLEHTSSMVLPHSWETYKDLLSSCLNLNDNVHREVFQNLVERNARVQRPRKCEEITQQPPQQRIVQLFDSIRSSHDITSVSAASLGAIDDKAALVVNLLEWAATPFRYGVSRVYTGARLLRKWKIAGVDVDTCIISFFAESQMNDQLNMDNIYHIVSELVRSQTFSVGKYLQWLMAKGVAHFPRNSEHKPLSGDLALLMQLPVSRLPEHVRNLRNTLLHRAGVEVSKEASTIAVLKASIAERLPRIFGSVAKTAVSRDPFPPDLTWAVKSELGQWIRRGITEFGRDPRSAFQDLHSGPGAEQSALTSGEFYTIRDILESFGDLSILADVLKQAAVCNDGIVLASAVDTVNYHFRSFCVIGATTDLFKRLVESYARLKRLGSTSLDLIFSLIDLGLRLPGELNTVALLRQDLSRIESKSSMAAPSPLSDHIPATFNEADPLFLVKLDQLLSSTSGIDESTLDTIFTLLIKQIESSGGHAKLSMNDTCRYLSYLRPFSPKRFDLMIVRWICGLLKSTTGVMLSQMLPPLIGVGCVTIQAFVFLVRRLLKSENMISNPRDLRVDLLQLLVPPPAGQSRYFDMVTYRFHLSRKEFLFKHPEEVFNIIRDAIALIDSQSQEETYCQGRVDLGHSAMALLQILLTQNPESAVQHCTEKLIGQHPSAVTVLTRALDSLLGLDTKTAPPDISVAEKVIELTNDFSLPFCQLKLQLLFNAESKGDVRNEIVDVMFKAAVADSRSRRSNWVGLVRLMSHDAVRQIRERAEKNFFAIPLFEESPDSCSAFAAENSSSLETAKLYLTIIEKLACSIPDAGPQAVVPVLTERMDLLLQRLISMQANYSGTTELSHAVDAEQIIRSRAQFERALAFWFSALLRMIVLHRTAFSVPSAALRPSALPEQTRLLISIFCITLARLPDSVLRLFPAADYFPHSMRAGDCRPCPGILLQTHALDVAASLIDTFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNLTLPMSLPSPAASGSTPAPTPSGNPTGGPSHPQQPAFVSGVPTGLPDGLNCGASHLCLQYRGRAIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRV
Length1594
PositionKinase
OrganismAspergillus udagawae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.118
Instability index47.47
Isoelectric point8.43
Molecular weight175828.52
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04390
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     424.18|     148|     230|     201|     377|       1
---------------------------------------------------------------------------
  201-  377 (218.09/167.19)	LGGEKVADFS..P.W...MGNHPEDVLNEQtaKQG......YYDRTQVS.QNESNTA.RPslyaqLKHRSGLQILSsvfaAALEKRQghSMVTAPS..TFKP..PPRVTLTDNKREAWLRDLANPNVPL...RKLSRTIPHGIRGRV..LLDQcltkwVpvgRAVWLAKCVGANEIRAFKRKgtsGALAIGLEakwvrDW
  427-  597 (206.09/105.35)	LASLEVAPFNslPvWllmLGIYWSNILRYR..KRGrrlaelLLDKLQLAiKSDSATSlRP.....LTERLSLHIRK....LTLEHTS..SMVLPHSweTYKDllSSCLNLNDNVHREVFQNLVERNARVqrpRKCEEITQQPPQQRIvqLFDS.....I...RSSHDITSVSAASLGAIDDK...AALVVNLL.....EW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     318.91|     103|     230|    1065|    1179|       2
---------------------------------------------------------------------------
 1065- 1179 (153.52/122.10)	PPAGQSRYFDMVTYRFHLSRKEFL.....FKHPEEVFNIIrDAIALIDSQSQEEtycqgRVdLGHSAMALLQILLTQNPESAVQHCTEKligqhPSAVTVLTRALDSLLGLDTKTAPPDI
 1301- 1408 (165.39/99.95)	PDAGPQAVVPVLTERMDLLLQRLIsmqanYSGTTELSHAV.DAEQIIRSRAQFE.....RA.LAFWFSALLRMIVLHRTAFSVPSAALR.....PSALPEQTRLLISIFCITLARLPDSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     380.47|      99|    1415|       3|     104|       3
---------------------------------------------------------------------------
    3-  104 (170.33/107.47)	PHS.SAGVqswGQPLHAVYSGTGRADLSQPLGQ..PDRQSEQPSMPVPQLQGRPPTLIDLTANDGDVLD.....REPPAKRLKIDVHAESVAG..DGS.PASAGAGESKTTPS
  139-  189 (59.12/28.22)	........................................ESAAGVVQDV..KPPSPPSFTG..............PPWKFAPADTIASDSAGaqDGA.PAK....EVQTTP.
 1419- 1522 (151.02/87.32)	PHSmRAGD...CRPCPGILLQTHALDVAASLIDtfPDEARHQCAR...YLREKCPPFARV.QNDSRFLYllgplGDSPSSNLTLPMSLPSPAA..SGStPAPTPSGNPTGGPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.60|      45|     327|     598|     670|       5
---------------------------------------------------------------------------
  623-  670 (75.59/84.37)	GVD...VDTC...IISFFAESQMNDQLNMDNIYHIVSELvrsQTFSVGKY....LQWL
  950- 1004 (65.01/27.67)	GIDestLDTIftlLIKQIESSGGHAKLSMNDTCRYLSYL...RPFSPKRFdlmiVRWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.56|      12|      18|     856|     867|       6
---------------------------------------------------------------------------
  856-  867 (20.44/14.71)	GATT.DLFKRLVE
  876-  888 (16.12/ 9.75)	GSTSlDLIFSLID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04390 with Med12 domain of Kingdom Fungi
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