<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04385

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMIGFLSQKPRSASLLGAALLLLGHITPVVIGLKTTPGSPCANVCNKVSSNTTASEIVCLDEQFSQTTKGSDFQNCVECQLESTYGDSSSGQRDVEWGLYNLRYAFSSCVYGFPEQVANISSPCVVSCQPLSSALDYDLDDPSGINFDTWCGASSFADNLISQCEFCYNLTSNMTDSQVYLANFTDSLAIGVVLEALRYNCHFRTPSGKAFPISPSRVFSESLLPQSTVDLTSPSGNANSGSSRLALIIALPILGFVILICILAVGCFFFIRWRRKQARKHRRSDHLHARWNDTTISTPAHGAWADPANNGMYSQPMHHPGSGHGFNFVDTDGRTQEVGFSKSNYVEITESPVTVPSTTHSPEHEKGYDAQAYIPERSVSPPQKQKLSSLQSQAGIISNNLLSVSEHLSDNRDLLSALVAYPGPSYPGRTQAPTLEQLLRTKLDPRVDDWVSRGRRAGASALEDQGALSESALAELWDWAPVEANQEARRRNWGGNFTLEEREMGIQNVVTGLRRQLEDEDEEESESEEEGEGEEEEMEVVGVRRKSGVGAGLEFDIAAPAPGSRQHQHQQKAAGHAVPLEDILRYMTTGIPPTQR
Length595
PositionHead
OrganismAspergillus udagawae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.379
Instability index57.54
Isoelectric point5.07
Molecular weight65055.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04385
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      16|      26|     330|     345|       1
---------------------------------------------------------------------------
  330-  345 (27.45/16.39)	TDGRTQEVGFSKSNYV
  358-  373 (29.19/17.85)	THSPEHEKGYDAQAYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.75|      30|      61|     133|     171|       2
---------------------------------------------------------------------------
  133-  163 (51.81/28.29)	ALDYD..LDDPSGINFDTwCGASSFADNLISQC
  195-  226 (46.95/26.65)	ALRYNchFRTPSGKAFPI.SPSRVFSESLLPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.15|      15|      15|      48|      62|       3
---------------------------------------------------------------------------
   48-   62 (25.29/16.37)	SSNTTASEI.VCLDEQ
   64-   79 (23.86/15.08)	SQTTKGSDFqNCVECQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04385 with Med8 domain of Kingdom Fungi
Unable to open file!