<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04379
Description |
Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MEVDQESQNRSANGGEEEAWQKTRAGKRIEELKLVEENIAALLHFAGCTLASLHPDPLSSFTSRELAVDDDEGEDGAKAGGATSGEEGEKLAEFSKYAEGYYATLNDIQLALRTSIRHLRVSRTSAAPLIDPSFGSLVTAGPAASAVGPGGVALAELLKPLEGKVPLWDGKMQRVREESREAQTNERLSVAASELEREAWSDLVLSLEAGRAE |
Length | 213 |
Position | Head |
Organism | Rhodosporidium toruloides (Yeast) (Rhodotorula gracilis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina>
Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.443 |
Instability index | 39.84 |
Isoelectric point | 4.71 |
Molecular weight | 22849.05 |
Publications | PubMed=29521624
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04379
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.60| 22| 60| 79| 100| 1
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79- 100 (40.06/22.06) AGGATS..GEEGEKLAEFSKYAEG
140- 163 (35.55/18.83) AGPAASavGPGGVALAELLKPLEG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.52| 13| 15| 180| 192| 4
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180- 192 (21.20/14.19) REAQTNERLSVAA
197- 209 (22.32/15.28) REAWSDLVLSLEA
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