<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04376

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDTLTAPPPLPPPTIPNGTSSHSQPSTSTHAHSSKDPQPEPALERELPVILQDLVPLSYIIDRVVAQAYSDLANLVETLPSQNDQARKRAIVDYVLQTRRQVVKLLVLARWSTEAERIQRAMNIVGFLSMQNHTLESTITSLTETRTMLSGARVRNYDLSTALAVLSTGTYTGLPASMREGFEEGAEKMGDEEVIDTLREVDEVIRWRLVMGKEYVPKEMRRRIWRVGDGRVVFGVEGLWEASFTYGGGKEDPDEDEDDERAEEGAEWFLLGVKFLFRVKDARGVWSSTPLGPLKDHLIDLCNRQLLRRPYLPPSPEPPQPPQPHIDAPPPTEADANREEKEKKWNEERREVIKKRRRDRPLNRAYTFLQRLALSYQLEAVHSSAARLAQTSWKGSLRVERAGQEREEVRVEYWSYRPDGSTTARQPSSTASRPGPGGTIIFSLRTPSPSSSSADAPAAPPPSSTSRQSVRERALRAALAKASSSTLPTPTASDTSPATEADDRPSDPDVPSRLSVTWLPPSSYAPSSASLDLSALLGSDLDVEAVIRQVTARHARETVQRLAEVVVGQGGEGAKGATVIYPKKRNDGDGAGTGDEAGEEVPYLHFPLVGPHAVSAHIVPTTGRFEFRLASASAASTGGEDGGIEEGEGSAAREQRLRLATERIEKERYGIAQPGQQANATGEDGWMRAVVDVVARIRASTILDDLETLVSLLSLPLASPPTRRLPLAPREYSKLGPNPAALTGRAAHLFIPLLRSTSGSMKDWFVVLVLFEEGVRAALVRTEERSDGMGSWLEIGEVGWIGGASAKAKGKERAGEGGVETGVAGTNLGYEIKAETLRSLWWHCVHRVALFKVEQQVHSRRIPYRLVDPSSANSNTAPSPLFAKPPKAAHLAVQPAGLLALSDAAKIADGEGAVLCVVGDGGLLRTTLHVRLRPTIASSLFSPSTKLPPNVLFNPSSGVLILATEDDLDGAFERLLRAYAILARALFDAYRARGRTDKRPSATAASPKKTAFAQQINGLKPGG
Length1023
PositionTail
OrganismRhodosporidium toruloides (Yeast) (Rhodotorula gracilis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
Aromaticity0.06
Grand average of hydropathy-0.405
Instability index50.09
Isoelectric point6.68
Molecular weight111167.06
Publications
PubMed=29521624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04376
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     334.69|     120|     141|     641|     781|       1
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  641-  781 (174.49/142.38)	DG.G..IEEGE.....GSAAREQ.RLRLATERIEKeryGIAQP..GQQANA.TGEDGWMRavvdVVARIrastILDDLETLVSLLSLP..LASPPTRRLPLAPreySKLGPNPaaltGRAAHLFI.P...LLRSTSGSMKDWF.VVLVLFEEGvraALVR
  787-  925 (160.21/90.90)	DGmGswLEIGEvgwigGASAKAKgKERAGEGGVET...GVAGTnlGYEIKAeTLRSLWWH....CVHRV....ALFKVEQQVHSRRIPyrLVDPSSANSNTAP...SPLFAKP....PKAAHLAVqPaglLALSDAAKIADGEgAVLCVVGDG...GLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     616.33|     196|     316|       4|     217|       2
---------------------------------------------------------------------------
    4-  217 (304.78/203.99)	LTAPPPLPP.PTIPNGTSSHSQPSTSTHAHSSKDPQPEPALERELPVI...............LQDLvPLSYIIDRVvaqaYSDLANLVETlpSQNDQARkraiVDYVLQTRRQV.VKLL.......VLARW.STEAERIQRAMNIVGFLSMQNHTLESTITSLTETRTMLSGARVRNYDLSTALAVLSTGTYTGLPASMREGFEEGAEKMGDEEVIDTLRevdevIRWrlVMGKEYVP
  306-  526 (311.54/172.28)	LLRRPYLPPsPEPPQPPQPHIDAPPPTEADANREEKEKKWNEERREVIkkrrrdrplnraytfLQRL.ALSYQLEAV....HSSAARLAQT..SWKGSLR....VERAGQEREEVrVEYWsyrpdgsTTARQpSSTASRPGPGGTIIFSLRTPSPSSSSADAPAAPPPSSTSRQSVRERALRAALAKASSSTLPTPTASDTSPATEADDRPSDPDVPSRLS.....VTW..LPPSSYAP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04376 with Med14 domain of Kingdom Fungi
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