Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAQPPALNLSHLQWRAPEFLLAFGSLSTPQLAMEYFSLSPFFDKASNNAQLRMQMMFSRGGMEGVDEEAELRRFVGLEFVIAYSTPPDLFIVHKRNRTSPTDSTVVGAFYILNGNVYQAPTLFEVLNERILTSLHALSTSFDSLTALKPHWTPSKLYTWDIKPPPQASTALAAAANGEPAAEDAVMREDAAADGAEQGKDAVQTAVKEEDEEKERPGEAFNPLLFRALQDVARTMEQPQVAGA |
Length | 243 |
Position | Head |
Organism | Rhodosporidium toruloides (Yeast) (Rhodotorula gracilis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.259 |
Instability index | 41.73 |
Isoelectric point | 4.78 |
Molecular weight | 26748.86 |
Publications | PubMed=29521624 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04374 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 54.27| 17| 19| 173| 189| 1 --------------------------------------------------------------------------- 173- 189 (30.35/19.29) AAANGEPAAED....AVMRED 190- 210 (23.93/13.86) AAADGAEQGKDavqtAVKEED --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FNPLLFRAL 2) LYTWDIK | 220 156 | 228 162 |
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