<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04355

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCVSKDEYMRTIAKVINAINCNSKPSAVPSLLQPSRIQSASQNYRSAGLGIPPDPQPTHQQHQQKVMDRYHTSLCQTPPMMQSQQSPSGALSGGNMQLSQSSLQQHSPVTHPVVPQVPYNMLSPIPSVPGSQNTSPNHQMYSRVKTEQKSSGNDGGAAEIPISDAMSARVWKREVPPPGNYYSAGFYDATSSNQYVERTHSSAPFMPRGTPISPSQQLTASPHHHHQHHQQHQPSVLENLINSSHYGSPMQSSQHVNGSGNQSVSDLPFGNAMQQNDERMYTEKLRSLRPYVESLRARAQQCRLEGNEIAASKFDTMCNVLDGKSRVSFEYLLQIEAWIYKKQQFLQVSLNTGTLQPQPLVDAVNAVLLINSEAQVGYGDRVQTNTGVPSAGQWSVQSSRSQQQASSQGLPNMVPSSVPVAHCPVRSTLMQSSIPLQTTSGQQVARHSIEHTYQRHSPYPNPNAGLRSGTQSVVLHHGLSRVQPAATVAALPPFSEANRAPATTDCSRVEDLYVMDDFLPTPIEAVSNNTSSQMEGLLPEAVRQELLAFGDRILADSNIEQMTDSHSVIVKFSLTSHNVPPLQLIIPKAYPNGEVMVGRAALDLDSFFFDDLQNVIHERLARPGLRTVTDFLETWESTVRGYYLGQQQQSLLPNSFDDILQNTNFSDFLS
Length718
PositionTail
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
Lineage
Aromaticity0.06
Grand average of hydropathy-0.573
Instability index63.29
Isoelectric point6.29
Molecular weight79418.64
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04355
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.06|      24|      26|     178|     201|       1
---------------------------------------------------------------------------
  152-  172 (21.59/ 6.62)	..QQHSPvTHPVVPQV.PYNMLSP..
  178-  201 (42.60/19.23)	GSQNTSP.NHQMYSRV.KTEQKSSGN
  204-  228 (34.86/14.59)	GAAEIPI.SDAMSARVwKREVPPPGN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.33|      20|      41|      78|      97|       2
---------------------------------------------------------------------------
   78-   97 (33.87/16.97)	SLLQ.PSRIQSASQ...NYRSAGL
  101-  119 (19.57/ 6.43)	PDPQ.PTHQQHQQKvmdRYH....
  121-  139 (29.88/14.03)	SLCQtPPMMQ..SQ...QSPSGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     387.56|     133|     170|     316|     485|       3
---------------------------------------------------------------------------
  316-  477 (200.11/136.79)	PFGNAMQQNDermyteklrslrPYVE...SLRARAQQCRLE........GNEIAA....SKFDTMCNVLDgKSRVsfEYLlqieawiYKKQQFLQ.....VSLNTGTLQPQPLVDAVNAVLLinseaqvGYGDRVQTNTGVPS.AGQWSVQSSRSQQQASSQGLPNMVPSSVPVAHCPV.RSTL
  496-  650 (187.45/79.71)	SIEHTYQRHS............PYPNpnaGLRSGTQSVVLHhglsrvqpAATVAAlppfSEANRAPATTD.CSRV..EDL.......YVMDDFLPtpieaVSNNTSSQMEGLLPEAVRQELL.......AFGDRILADSNIEQmTDSHSVIVKFSLTSHNVPPLQLIIPKAYPNGEVMVgRAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.94|      17|      21|     259|     279|       4
---------------------------------------------------------------------------
  240-  256 (28.39/ 9.52)	SNQYVERTHSSAPFMPR
  263-  279 (31.55/22.50)	SQQLTASPHHHHQHHQQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04355 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPSLLQPSRIQSASQNYRSAGLGIPPDPQPTHQQHQQKVMDRYHTSLCQTPPMMQSQQSPSGALSGGNMQLSQSSLQQHSPVTHPVVPQVPYNMLSPIPSVPGSQNTSPNHQMYSRVKTEQKSSGNDGGAAEIPISDAMSARVWKRE
2) IPLQTTSGQQVARHSIEHTYQRHSPYPNPNAGLRSGTQSVVLHH
3) MGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDA
4) SNQYVERTHSSAPFMPRGTPISPSQQLTASPHHHHQHHQQHQPSVLENLINSSHYGSPMQSSQHVNGSGNQSVSDLPFGNAMQQN
75
482
1
240
222
525
39
324










Molecular Recognition Features






MoRF SequenceStartStop




1) YYSAGFY
229
235