<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04351

Description "BMA-CDK-8, isoform d"
SequenceMIDYQFKEELIKTRERVEDLYSFEGFKVGRGTYGHVYKAQPRHPEQIPGNGAKEFALKLIEGQGFSMSACREIALLRELKHPNLIKLQRVFLTTDRKVWLLFDYAEHDLWHIIKFHRAAKQKKQPVLVPKGMVKSLLYQILDGIHYLHSNWILHRDLKPANILVMGEGPGVERGRVKIGDMGFARIFHNPLKPLAELDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHQDQLNRIFTVMGYPSESDWQDLKKMPEYQKLTQDFKRANYANCTLQRYMDKHKIKADTRSFSLLQRLLTMDPIKRVTAQDAMDDAYFKEDPRPTADVFSGCDIPYPKREFLSDENDDKSASASKPQQVQPPQQSQQQPIGMHPQQSVMEPAAKKMRMQQGPQISTTQQMESMINAPTSGMFVTSGAQDYPPVGSGPAISSKGGIPFEQHSQQQIMQSQHINSGMQQMSYGHQQQHQVINQGPNIYQQQQIGMNQQIGGPPQGQMTQRSVQMSAQSSVLQSSYQQQMVQPGMISSQQMMGSGNGMLGQQGSMTGPMGGPQTQMGPPQGQMGPQGPTIMQQMRPQMSYVDQNGRVIQSGGIIIQPGQEMMPQQGHYMIQQQQWPQMQPRF
Length643
PositionKinase
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
Lineage
Aromaticity0.08
Grand average of hydropathy-0.621
Instability index56.21
Isoelectric point8.86
Molecular weight72973.76
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04351
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     355.65|      76|      80|     395|     472|       1
---------------------------------------------------------------------------
  375-  445 (119.25/44.55)	ASAS.KPQQVQ....PPQQSQQQ........PI........GM......HPQQSVMEPAAKKM.RMQQGPQISTTQQ..MESMINAPTSGMFVTSGAQdyP
  446-  525 (98.66/32.08)	PVGS.GPAISSKGGIPFEQHSQQ........QIMQSqhinsGMqqmsygHQQQHQV.........INQGPNIYQQQQigMNQQIGGPPQGQMTQRSVQ...
  526-  579 (86.49/27.56)	........MSAQSSV.LQSSYQQ........QMVQP.....GM......ISSQQMM.GSGNGM.LGQQGS.........MTGPMGGPQTQMG........P
  580-  639 (51.24/13.23)	PQGQmGP....QGPTIMQQMRPQmsyvdqngRVIQS..ggiII......QPGQEMMPQQGHYMiQQQQWPQM.............................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.54|      29|      35|     284|     317|       2
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  284-  317 (48.93/44.03)	QK.LTQD.FKRanyanCTLQRYMDKHKIKADTRS....FS
  320-  354 (40.61/25.26)	QRlLTMDpIKR.....VTAQDAMDDAYFKEDPRPtadvFS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.65|      11|      83|     181|     196|       4
---------------------------------------------------------------------------
  152-  162 (19.86/10.71)	ILHRDLKPANI
  186-  196 (20.78/ 6.77)	IFHNPLKPLAE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.11|      25|     170|      86|     114|       5
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   86-  110 (44.96/42.45)	KLQRVFLTTDRKVWLLFDYAE.....HDLW
  122-  151 (38.15/23.48)	KKQPVLVPKGMVKSLLYQILDgihylHSNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.49|      21|      30|     230|     254|       7
---------------------------------------------------------------------------
  230-  254 (30.36/30.64)	IFAEL.LTSEPVFfcreEDIKASSPY
  262-  283 (36.13/23.22)	IFTVMgYPSESDW....QDLKKMPEY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04351 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GRVIQSGGIIIQPGQEMMPQQGHYMIQQQQWPQ
2) PKREFLSDENDDKSASASKPQQVQPPQQSQQQPIGMHPQQSVMEPAAKKMRMQQGPQISTTQQMESMINAPTSGMFVTSGAQDYPPVGSGPAISSKGGIPFEQHSQQQIMQSQHINSGMQQMSYGHQQQHQVINQGPNIYQQQQIGMNQQIGGPPQGQMTQRSVQMSAQSSVLQSSYQQQM
3) QPGMISSQQMMGSGNGMLGQQGSMTGPMGGPQTQMGPPQGQMGPQGPTIMQQMRPQMSYVDQ
606
361
543
638
541
604










Molecular Recognition Features






MoRF SequenceStartStop




NANANA