<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04345

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSEGSNFSDDSSSDGKEEFTRFSSEKFTDNIKYNWNLEKEFSRNNNKHDEEFEEILSYLPSVPQSHNSGMIPFGSLLQFASHKISQELIVLSELIPKAYDQSKKISLVEFSFVAMNLFSKILAILKWYRYFKKYRLCTPIQYFLDQQSQIFRDTADALYTIAKVELRGARLPYFEMEAALNNIWQNFNCLPLAIKKRFVSDPPVSKIDQKIILSRLNHVLKNRLSLISTKIPIVITDITIRNGTVSLKVNGEYETVLTLLSSDICEKWTLLHIKILVEQHDIGYGTTLVHPLQLHKVHQHLQKLMNESNNPINTMHDFMHKFCLSLQLDVIFCEATQLIQNQYNRKLIIEKYDMDGGKLVISYWPKYNGKKIFPSQYKLIITHSKSTSFHGLLVYHMPYKSNMPQLDTNTGRLSLNTLIGTTTAIRAKEKLQILRKKLNKINPIAGILISGELLQIIKFPLLEDINISEDEYLYFTVNRFTGVYFCSFKYDDSDENISKLNETLNNNGHINEIQRIINNIRVNFLMKKYKEIISLNYLVVSEAILPEKAREFLKDKEKDRICIKFHRDLPYYCIFFFTKYIGNGISISQHIVFKNSNDEVIIFPFNDVIQEPKEEDIESNINTKLLFKNSSNTPKISHLSSEIKNLILVMDMKVRHLRLTEDFKKKGITVEPINREKPNDPIKLKINFIPFLLPKDLQFLNNIKNLLVFCDNRAKLLWPFEFYIQNIPIIADFYKHTLLEDVSTKHCGKRNFILSSRTSLSMACTSASLDIVSTNFIEKIAICTMIYKQVFHFSKYYYAYYRKFCNIKIFNFQKLIIAYGKNRDQLMFLTYKPSRKTYIMSFGVDSPRNFVNGSNDVYQFSNQTYINIHNSVSLYIHEMTRKEYFLRDVIHYLVNTTDALTYLYRSIKPKFISTEAFGQISRETIFHNQEFRFELFIVDEHSFRLSNGIFSLGIYVYDINFVYIKDCSYGEPSLIGLQNFLKVQTQNVTSKSLNQMNPVERNAYFTTSRKVYRLSLSAFERLTSLNTIDENYSVLGKYLINLRSFDKLRIIFSQQKEKTISKGCNIRFNDFQRTSFYIKVAFQGATLPNGTIPCTIHFTVYLEPNTFDLKAKIEYEGSFKPSESEIKMAEEYFEKVLSNGNCPQGVYSFINILRLTYPMSFANLTLLMELEMKPPSNHYYRLSLDLVSNDHRNSDQTVQYSPSFLIDEKSFRVLVPVSLRPQKRESKDSKCIDPDRLKLNAVWDIKNNRLNLHKPATDLMKFINDKIKKHNEIAKENNECVIESCIKILLIHQLKEPVVIT
Length1301
PositionTail
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.267
Instability index37.45
Isoelectric point9.04
Molecular weight152024.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04345
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.66|      41|      61|     823|     870|       1
---------------------------------------------------------------------------
  823-  870 (56.08/51.36)	RDQLMFLTYKPSRKTYImsFGVDSPRnFVngSNDVY.QFSNQTYinIHN
  887-  928 (65.58/36.49)	RDVIHYLVNTTDALTYL..YRSIKPK.FI..STEAFgQISRETI..FHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.72|      46|      59|     611|     657|       6
---------------------------------------------------------------------------
  611-  657 (72.16/46.04)	EP.KEEDIESNINTKLLFkNSSNTPKISHLSSEIKNLILVMDMKVRHL
  671-  717 (75.57/44.27)	EPiNREKPNDPIKLKINF.IPFLLPKDLQFLNNIKNLLVFCDNRAKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     328.41|     102|     860|     226|     329|       7
---------------------------------------------------------------------------
  226-  329 (170.39/113.17)	LISTKIPIVIT.DITIRNGTVSLKVNGEYETVLTLLSSDI...............CEKWTLLHIKILVEQHDIGYGT.TLVHPLQLHKVHQHLQKLMNE..SNNPINTmhDFMHKFCLSLQLD
 1087- 1207 (158.02/98.43)	LPNGTIPCTIHfTVYLEPNTFDLKAKIEYEGSFKPSESEIkmaeeyfekvlsngnCPQGVYSFINILRLTYPMSFANlTLLMELEMKPPSNHYYRLSLDlvSNDHRNS..DQTVQYSPSFLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.42|      34|     553|     407|     444|       8
---------------------------------------------------------------------------
  407-  444 (46.21/45.55)	DTNTGRLSlntLIGTTTAIRAKEKlQILRKKLNKINPI
  966-  999 (60.22/43.62)	DCSYGEPS...LIGLQNFLKVQTQ.NVTSKSLNQMNPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04345 with Med14 domain of Kingdom Metazoa
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