<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04344

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQKCTSKDEYMRTIAKVINAINCNSKSSSMPSVLSNHYNKNGLSPTTGNNPPSNIPPDPQPTQQSDIPLSVVGSGNVTTNTEVPSSRQLNQVSSSSVPIQRQSPLPSNNNITSHTPPVSGGIQQQSSGNSGFPNTQQQINPSTGYGSQIPQNMNQPQFMRNSQQIKNEYNGMNEQVNYGIPQVNSMYPQTMNKPSMPTEDMMSGNPMIQRQRGWNVQQDNGQYMQNPMIQVPQPNMGMGQPMMQYINQQQPYTEYAYQNSTIPINNSMNFSNNCLPIQNEKMYEGKLKDLRQHANMIKSKANYYRSSGNPTAASRLDYIYEVLIGEKKPPYETIIKIEEEINKILLSQNIMVSNIGMSSQIGGPIMQEPKLLQQQYYSQPQWMGPQQISGMNSGPSPYSVTGANPLSHQQYNVPNSPSGSQQQQSLRHSPYQIPNKHTQGNYTSRQSSLPHSKTQSQPTNINTYQNNFHYPSQSLTTTITNNGSTLEELYSTSYDQMLGSKSGTVDEINSLYGQQQSQNNPPNFTTYLTSSMNQEINTLKSQFTFKNICGTYDGNYINVDVVFNNFEKDFPPFRLVIPKTYPAVPVSFEQLPLDIESFLYEEVQSHMYSEIRKKNPKTITDILKIAESAALDFYSKQQCNQINTSGLDDLFRSSQYDSALQ
Length710
PositionTail
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.866
Instability index62.90
Isoelectric point6.16
Molecular weight80065.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04344
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     196.24|      34|      34|     178|     211|       1
---------------------------------------------------------------------------
   76-  114 (36.43/ 9.70)	SSSMPSvlsnhyNKNGLSP..TT........GNNPP...S.NIpP..DPQPT.QQS
  178-  211 (65.26/23.30)	NSGFPN......TQQQINP..STG......YGSQIP...Q.NM.N..QPQFM.RNS
  215-  244 (35.35/ 9.20)	KNEYNG......MNEQVN............YG..IP...QvNS.M..YPQTMnKPS
  436-  478 (29.88/ 6.62)	QIS..G......MNSGPSPysVTGanplshQQYNVPnspS.GS.Q..QQQSL.RHS
  497-  521 (29.32/ 6.35)	S..LPH......SKTQSQP..T...................NI.NtyQNNFH.YPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.26|      30|      32|     246|     275|       2
---------------------------------------------------------------------------
  259-  293 (54.94/23.92)	RQRGWNVQQDNGQY.MQNpmiqvPQPNMG..MGQPM.MQ
  294-  327 (32.73/11.31)	Y...INQQQPYTEYaYQN..stiPINNSMnfSNNCLpIQ
  340-  359 (25.59/ 7.26)	RQHA.NMIKSKANY.YR.............sSGNP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.73|      14|      20|     139|     152|       4
---------------------------------------------------------------------------
  139-  152 (24.99/12.54)	NQVSSSSVP....IQRQS
  158-  175 (21.74/ 9.91)	NNITSHTPPvsggIQQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.29|      18|      18|     528|     545|       6
---------------------------------------------------------------------------
  528-  545 (29.28/14.04)	ITNNGSTLEELYSTSYDQ
  547-  563 (25.35/11.23)	LGSKSGTVDEINSL.YGQ
  567-  583 (23.66/10.01)	.QNNPPNFTTYLTSSMNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.35|      24|     317|      47|      71|       7
---------------------------------------------------------------------------
   47-   71 (38.20/28.69)	DYVFQK..CTSKDEYmRTIAKVINAIN
  366-  391 (38.15/23.37)	DYIYEVliGEKKPPY.ETIIKIEEEIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04344 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MATLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQ
2) SSMPSVLSNHYNKNGLSPTTGNNPPSNIPPDPQPTQQSDIPLSVVGSGNVTTNTEVPSSRQLNQVSSSSVPIQRQSPLPSNNNITSHTPPVSGGIQQQSSGNSGFPNTQQQINPSTGYGSQIPQNMNQPQFMRNSQQIKNEYNGMNEQVNYGIPQVNSMYPQTMNKPSMPTEDMMSGNPMIQRQRGWNVQQDNGQYMQNPMIQVPQPNMG
3) WMGPQQISGMNSGPSPYSVTGANPLSHQQYNVPNSPSGSQQQQSLRHSPYQIPNKHTQGNYTSRQSSLPHSKTQSQPTNINTYQNNFHYPSQSLTTTITNNGSTL
1
77
431
51
286
535










Molecular Recognition Features






MoRF SequenceStartStop




NANANA