<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04343
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MSENSDDNGYDKKDDSFEITIPEFPNDSSDDPSFSDNENSQVKKKLEKGEKLPNLPHVAEQHAPGTMPLAVLLQFVCQKINQELFSLTEVVCNTSDIGRKVALVQFSYTAKNLLSKLLAIVKWFRYFKRYRLCIPIQNFLDQQLQHYRETADTLCGIARGELTYARMPPYNIDSAIDVVCGVYARLPQSIKKRFIPEPELSTQEIANVLARINLAIKTRLSFMTQSFPTQIKNIIVHNGTVTFVVPGEFEITLTLPGETLDVKWRLLRVRILVQDYEFGDGKELVHYLQLKKLHKFCQKLLDTSKKPVISVFNFLHDFCVTLQFDLIFGEILQLTQGTYRNKVFINTCNVQKRYISLKYWVKKRTKNTPSSFNQIVFYISSKSKDGGVVVEFRPSNSFPLDVYKEFEGKPSVHNILRSAIEYNIYRKLAILKEQLENCKPKSYVKLTGNLLPKVTYYLLSKDINGENDELSFGVNFSTGEYMYVGDNLKESLLLKAIVVGLNNNMEHKKLEKCLDGMRTEFIMKKYVKSVNMLNVKIVPERILPSIARKYAFFEHSVKLYFQIIKEPQHYVVLTFTDPKRKGLWVNFFLISLNEGKSTVVKLNPSNFYTPSKINTPDERYYLGEIGNAIKYSKKEYSLQYTPHEIGAIINGIENKVNMIAVCDEFLKKNVTLGSVKNDCISNSPYLEIPNISKLIGSDNSKFFDNMKRIILRNDSRFKHIWPLEYLLINTPIVEDFYKRDINGQNLVQLTGKKRCFHDIRSSGIVLPIVSFYEVITSALVDKMKTFSMLYKHVFEFAHSYYRYYNNYCRIKLYSYHKLIIAYGEDRDQLVFLTYKASKDSFLLSFGQDLKQNFVNGDTDDSSDQETSTLWNPHNLVASFLSEKSGRKNFLPELVDYLINTTKPLTSLCKGIRHKIICSSALTQILIGESMYSEEFDIQLVPHSEYIFKIICGHMIIEVFMYAKNYVYLKDSSYEKARLYGFKELLKGFGGNVIDMNAIVNDETSIEKGARSLPASNREEIEEVMSNPLSLPSSMNVDSKRDDNYMAMEDDTESKDKYNEEYFSSSRDLIKMSHDSFDKLLYQDPKIKLISDLRNYLYSLRSFERLTTILVHNYGKPILGGGGLMIHSVNVTHYMVRATFSAAKRSDGHIPCNINFIIFIERDTFKIKLKLEYVGAFRPTDDEIRIAEEYFEYVLMYTESPQMVYSFMNLIRMIFPRFFSCITNLMSLQLNPDPLNFYTMNFEFVNLMHRKEDSMPKYVSQILINEHSGRILIPITIRPQSIYPNHKNNEPNGKIKLDFVWEASNNEVYIHNVNDDFFKMINQRIIQFNSTIKESMECTLEACIRYILKNEIKSI |
Length | 1354 |
Position | Tail |
Organism | Strongyloides venezuelensis (Threadworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae>
Strongyloides.
|
Aromaticity | 0.12 |
Grand average of hydropathy | -0.278 |
Instability index | 39.73 |
Isoelectric point | 8.56 |
Molecular weight | 157039.22 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04343
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.16| 23| 25| 184| 208| 1
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184- 208 (31.08/30.48) ARLPQSIKKR..FIPEpELSTQeIANV
210- 234 (36.08/23.50) ARINLAIKTRlsFMTQ.SFPTQ.IKNI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.90| 40| 163| 786| 825| 2
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786- 825 (76.33/45.62) FSMLYKH....VFEFAHSY.YRYYNNYCRIKLYSYHKLIIAYGED
947- 991 (63.56/36.71) FKIICGHmiieVFMYAKNYvYLKDSSYEKARLYGFKELLKGFGGN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 31.94| 9| 33| 728| 737| 4
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728- 737 (14.29/11.86) INTPIVeDFY
764- 772 (17.65/ 9.31) IVLPIV.SFY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 91.94| 29| 33| 608| 638| 5
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608- 638 (46.76/36.75) YTPSK....INTPDERYYLGEIGNaiKYSKKEYSL
640- 672 (45.18/28.94) YTPHEigaiINGIENKVNMIAVCD..EFLKKNVTL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.83| 37| 125| 1167| 1211| 7
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1167- 1211 (53.41/58.81) KLKLEYVgaFRPTDDEI...RIAEEYFEYVlmytesPQMVYSFMNLIR
1293- 1332 (58.42/40.80) KIKLDFV..WEASNNEVyihNVNDDFFKMI......NQRIIQFNSTIK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.47| 15| 26| 143| 157| 8
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143- 157 (28.83/17.38) QLQHYR.ETA.DTLCGI
166- 182 (19.64/ 9.56) RMPPYNiDSAiDVVCGV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.76| 18| 26| 486| 511| 9
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486- 505 (23.19/30.77) DNLKESLLLKAIVVGLnnNM
515- 532 (31.57/15.03) DGMRTEFIMKKYVKSV..NM
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