<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04343

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSENSDDNGYDKKDDSFEITIPEFPNDSSDDPSFSDNENSQVKKKLEKGEKLPNLPHVAEQHAPGTMPLAVLLQFVCQKINQELFSLTEVVCNTSDIGRKVALVQFSYTAKNLLSKLLAIVKWFRYFKRYRLCIPIQNFLDQQLQHYRETADTLCGIARGELTYARMPPYNIDSAIDVVCGVYARLPQSIKKRFIPEPELSTQEIANVLARINLAIKTRLSFMTQSFPTQIKNIIVHNGTVTFVVPGEFEITLTLPGETLDVKWRLLRVRILVQDYEFGDGKELVHYLQLKKLHKFCQKLLDTSKKPVISVFNFLHDFCVTLQFDLIFGEILQLTQGTYRNKVFINTCNVQKRYISLKYWVKKRTKNTPSSFNQIVFYISSKSKDGGVVVEFRPSNSFPLDVYKEFEGKPSVHNILRSAIEYNIYRKLAILKEQLENCKPKSYVKLTGNLLPKVTYYLLSKDINGENDELSFGVNFSTGEYMYVGDNLKESLLLKAIVVGLNNNMEHKKLEKCLDGMRTEFIMKKYVKSVNMLNVKIVPERILPSIARKYAFFEHSVKLYFQIIKEPQHYVVLTFTDPKRKGLWVNFFLISLNEGKSTVVKLNPSNFYTPSKINTPDERYYLGEIGNAIKYSKKEYSLQYTPHEIGAIINGIENKVNMIAVCDEFLKKNVTLGSVKNDCISNSPYLEIPNISKLIGSDNSKFFDNMKRIILRNDSRFKHIWPLEYLLINTPIVEDFYKRDINGQNLVQLTGKKRCFHDIRSSGIVLPIVSFYEVITSALVDKMKTFSMLYKHVFEFAHSYYRYYNNYCRIKLYSYHKLIIAYGEDRDQLVFLTYKASKDSFLLSFGQDLKQNFVNGDTDDSSDQETSTLWNPHNLVASFLSEKSGRKNFLPELVDYLINTTKPLTSLCKGIRHKIICSSALTQILIGESMYSEEFDIQLVPHSEYIFKIICGHMIIEVFMYAKNYVYLKDSSYEKARLYGFKELLKGFGGNVIDMNAIVNDETSIEKGARSLPASNREEIEEVMSNPLSLPSSMNVDSKRDDNYMAMEDDTESKDKYNEEYFSSSRDLIKMSHDSFDKLLYQDPKIKLISDLRNYLYSLRSFERLTTILVHNYGKPILGGGGLMIHSVNVTHYMVRATFSAAKRSDGHIPCNINFIIFIERDTFKIKLKLEYVGAFRPTDDEIRIAEEYFEYVLMYTESPQMVYSFMNLIRMIFPRFFSCITNLMSLQLNPDPLNFYTMNFEFVNLMHRKEDSMPKYVSQILINEHSGRILIPITIRPQSIYPNHKNNEPNGKIKLDFVWEASNNEVYIHNVNDDFFKMINQRIIQFNSTIKESMECTLEACIRYILKNEIKSI
Length1354
PositionTail
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.278
Instability index39.73
Isoelectric point8.56
Molecular weight157039.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04343
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.16|      23|      25|     184|     208|       1
---------------------------------------------------------------------------
  184-  208 (31.08/30.48)	ARLPQSIKKR..FIPEpELSTQeIANV
  210-  234 (36.08/23.50)	ARINLAIKTRlsFMTQ.SFPTQ.IKNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.90|      40|     163|     786|     825|       2
---------------------------------------------------------------------------
  786-  825 (76.33/45.62)	FSMLYKH....VFEFAHSY.YRYYNNYCRIKLYSYHKLIIAYGED
  947-  991 (63.56/36.71)	FKIICGHmiieVFMYAKNYvYLKDSSYEKARLYGFKELLKGFGGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.94|       9|      33|     728|     737|       4
---------------------------------------------------------------------------
  728-  737 (14.29/11.86)	INTPIVeDFY
  764-  772 (17.65/ 9.31)	IVLPIV.SFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.94|      29|      33|     608|     638|       5
---------------------------------------------------------------------------
  608-  638 (46.76/36.75)	YTPSK....INTPDERYYLGEIGNaiKYSKKEYSL
  640-  672 (45.18/28.94)	YTPHEigaiINGIENKVNMIAVCD..EFLKKNVTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.83|      37|     125|    1167|    1211|       7
---------------------------------------------------------------------------
 1167- 1211 (53.41/58.81)	KLKLEYVgaFRPTDDEI...RIAEEYFEYVlmytesPQMVYSFMNLIR
 1293- 1332 (58.42/40.80)	KIKLDFV..WEASNNEVyihNVNDDFFKMI......NQRIIQFNSTIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.47|      15|      26|     143|     157|       8
---------------------------------------------------------------------------
  143-  157 (28.83/17.38)	QLQHYR.ETA.DTLCGI
  166-  182 (19.64/ 9.56)	RMPPYNiDSAiDVVCGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.76|      18|      26|     486|     511|       9
---------------------------------------------------------------------------
  486-  505 (23.19/30.77)	DNLKESLLLKAIVVGLnnNM
  515-  532 (31.57/15.03)	DGMRTEFIMKKYVKSV..NM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04343 with Med14 domain of Kingdom Metazoa
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