<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04341

Description Mediator of RNA polymerase II transcription subunit 17 (inferred by orthology to a human protein)
SequenceMNDSKKIDECMPPPKTIPSSTTLTSDDSKFVKPIGIPNKSRKYVYVEPKKEWNVIEYSLEGTEALMPPKSFQESLAEKALRIDWKKIVGSNVTYDDPELVYDMESDKALDLVDKILTLKIHQKSYKQPTHHTNNSTKLVIKPNDLQINKNNGLYNEDKERVRFNKLVKEANEAGLELNDDNMDYEELSKHVDGASIDKIDGPISVKEMEQMVENNIVYENYRNRKYIEGETNLEKKKKSKDKESDDEDIGYMIGKVAIESFKEGRIVQELEDQGLPSAKKIIHNSQVASKIRYLVQKRLQRKTLEYHFIGMALQNDEPKTIYQILKPSSNNTFGIIPHDTSSEVFDPTKCDEFVKELTDRQIEAAKKAWDALELQTNEFDIFSQFKNDALEAKSRGEDIKTMSIHFGSTKIMIPVIVKDSFSSEPRKSDEMSSDSEDEDEDFQMEVDKESEGGDHVEPTSSVAFYINRSGKLLGCKIDGESYSLDKPEFLSNELTNKMLEAIENNEGNKKDEEIASDDGSLDSRGRNKEKDKESSSRAQSPIVPEAGPWHKVAKNLHEALQHVNYLLDQLRVMDTSYMKPLTVAENTGDENTAINSKLYLWVAKRKALEESVGILETGTKHRKVDTESFEDKQAFFNELKSMREFWRLRKVGKFLTGDLGYRIFGSNFIPSESFDVTRKSSAILEEEKKHKSETGDTSPLSYLQVVVPYDLMRRTVMSVDIIIDHNAVADESLSKRKDNSDLEYMVVKPEDAMKIHWRKALLWAQESLICRDILKILFSDAAQATDIFSMQRENVLMVSLFSNVILKIQLDFYPFKDGNLPQPGIPVLNTLLRHLFLSDLCIRPKLLQQFVTLPLIDSQDYIAGRTFSDASKSEMKEMINYTKHTTLLSRICKVASHYKLVQEVINELQNFSIQYSDPSLSWKFYRITSIESFINVVLSNRGFVDIIPKQLFTISITHDNISISIRAKEGKDLFECGHDLEIFVKSLKMVYCRYIINSIAIQSKHWVWYVLSSNLRFSESHYSDACDLTLYVSNVSGLYHIHFFINYVTLEKNITVERNIDLKWQENENSNSETNKDNEKYIYLDYNSLIGDSLLKKFDFLFAILR
Length1106
PositionHead
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.09
Grand average of hydropathy-0.552
Instability index42.05
Isoelectric point5.45
Molecular weight127239.74
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP04341
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.76|      38|      66|     146|     184|       1
---------------------------------------------------------------------------
  146-  184 (59.84/33.57)	QINKNNGLYNEDKERvRF....NKLVKEANEAGLELNDDNMDY
  210-  251 (58.92/29.42)	QMVENNIVYENYRNR.KYiegeTNLEKKKKSKDKESDDEDIGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      19|      36|     467|     485|       2
---------------------------------------------------------------------------
  467-  485 (33.22/18.66)	NRSGKLLGCKIDGESYSLD
  504-  522 (31.97/17.70)	NNEGNKKDEEIASDDGSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.14|      26|     193|      85|     110|       6
---------------------------------------------------------------------------
   85-  110 (42.11/32.01)	KKIV.GSNVTYDDPELVYDMESDKALD
  260-  276 (19.33/ 9.98)	.........SFKEGRIVQELE.DQGLP
  279-  305 (33.70/23.88)	KKIIhNSQVASKIRYLVQKRLQRKTLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.46|      24|     133|     589|     623|       7
---------------------------------------------------------------------------
  589-  618 (34.68/41.20)	DENTAIN...SKLYLWVAKRkaleesVGILETG
  631-  657 (38.78/19.35)	DKQAFFNelkSMREFWRLRK......VGKFLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.38|      23|     139|     700|     746|       8
---------------------------------------------------------------------------
  673-  698 (32.26/33.68)	SFDVTRKSSAILEEekkHKSETGDTS
  718-  740 (37.12/17.93)	SVDIIIDHNAVADE...SLSKRKDNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      19|      38|     380|     398|      10
---------------------------------------------------------------------------
  380-  398 (33.31/18.28)	DIFSQ..FKNDALEAKSRGED
  419-  439 (27.06/13.57)	DSFSSepRKSDEMSSDSEDED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.53|      13|      39|     700|     713|      11
---------------------------------------------------------------------------
  700-  713 (19.97/16.74)	LSYLqVVVPYDLMR
  742-  754 (24.56/15.28)	LEYM.VVKPEDAMK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04341 with Med17 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELTNKMLEAIENNEGNKKDEEIASDDGSLDSRGRNKEKDKESSSRAQSPIVPEAGP
2) SSEPRKSDEMSSDSEDEDEDFQMEVDKESEGGDHVEPTSS
493
422
548
461










Molecular Recognition Features






MoRF SequenceStartStop




1) KFVKPIG
2) KSRKYVYV
29
39
35
46