<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04339

Description Cyclin-dependent kinase 8 (inferred by orthology to a C. elegans protein)
SequenceMIDTKFRDELASKRERVELLYSFRGSKIGRGTYGHVYKATPRFETPENKGKTYALKLIEGNGISMSSCREIALLRELSHPNLIKLNRVFLSPERKVWLLFDYAEHDLWHIIKFHRNAKQKKQAVMVPKSMVKSLLFQILDGIHYLHTNWILHRDLKPANILVMGDDPYERGRVKVADMGFARTFHTPVRPLADLDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHKDQLSRIFQVMGYPQDADWPDLKKMPEYQRLSKDFKRQTFSECALYKYLEKHKVKTNDKGFSLLQKLLTFDPLKRISAIDAINDAFFKESPKPTLDVFRGGPIPYPRREFMQDENEEKIIGKHISQQNIQIQQHMINNKLVQQGNNQIRQISEPDIKSNQFSNITMANQPEFNHLNNHSGNLNQPPPQQVNVFNDGNQQNVVQMQQNQYNQQAIFTGHDQNRMMMQQQQQQPVVQNAIRGPNGQFISQQQSRIISQDQNRMMMPQNQHQFNQQQQQIFVSHDQNRMMMQQQNRMIQSQGQNNMMPMQQQYIQPQQQHQIPPQQQQQQQQQQQQ
Length585
PositionKinase
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.09
Grand average of hydropathy-0.784
Instability index49.98
Isoelectric point9.40
Molecular weight68722.61
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04339
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     270.74|      39|      39|     470|     508|       1
---------------------------------------------------------------------------
  375-  429 (31.67/10.51)	HisQQNIQIQQHMINNKLVQqgnNQIRqisEPDIK..SNQFSNItmanqpefnhLNN
  430-  463 (52.85/23.03)	H..SGN...LNQPPPQQV.....NVFN...DGNQQNVVQMQQNQ..........YNQ
  470-  508 (75.20/36.24)	H..DQNRMMMQQQQQQPVVQ...NAIR...GPNGQFISQQQSRI..........ISQ
  515-  532 (24.78/ 6.44)	M..PQNQHQFNQQQQQI..................FVS...................
  533-  565 (59.16/26.76)	H..DQNRMMMQQQNR..MIQ...S..Q...GQNNMMPMQQQ.Y...........IQP
  566-  583 (27.09/ 7.80)	Q..QQHQIPPQQQQQQ.....................QQQQ................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.06|      23|      37|      90|     125|       2
---------------------------------------------------------------------------
   65-   87 (39.87/20.56)	MSSCREIALLRELSHPNL...IKLNR
   90-  115 (37.18/52.09)	LSPERKVWLLFDYAEHDLwhiIKFHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.14|      23|      39|     191|     217|       3
---------------------------------------------------------------------------
  191-  217 (33.50/33.96)	LADL...DPVvvtFWYRAPELLlGAKHYTK
  228-  253 (37.65/24.37)	FAELltsEPV...FFCREEDIK.ASSPYHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.98|      13|     131|     168|     180|       6
---------------------------------------------------------------------------
  168-  180 (25.10/21.28)	Y.ERGRVKVADMGF
  300-  313 (20.88/16.35)	YlEKHKVKTNDKGF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04339 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IQQHMINNKLVQQGNNQIRQISEPDIKSNQFSNITMANQPEFNHLNNHSGNLNQPPPQQVNVFNDGNQQNVVQMQQNQYNQQAIFTGHDQNRMMMQQQQQQPVVQNAIRGPNGQFISQQQSRIISQDQNRMMMPQNQHQFNQQQQQIFVSHDQNRMMMQQQNRMIQSQGQNNMMPMQQQYIQPQQQHQIPPQQQQQQQQQQQQ
383
585










Molecular Recognition Features






MoRF SequenceStartStop




NANANA