<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04336

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNYDGGNDSVPFGVLLKYSCHKISQELIVISELLPKYKDYNRKITITEFSYMARCLVSKILAIVKWLRSYNEHKTCKEIQSFLETQEHYFRDTADALCAIARNELVIARVPMYEVDAAVRLSYGQDIIMPLAIKKRFVPEKHLTKTERSKILAAINKNIYSRLSVISSILPSKIEGITIKNGIMTLTVSGEFEVSLTLFNDDLSTKWTLLDIKILIEQYDVGYGKKLVHPMQLFSMHQYLQQKMLVSKNPMVDLYNYLHDFCTSLQLDVLFCETSQLIGAQYKNKLIIEKYDQDGGVLIISFWPALKRKQCVPSQYKIKVFKDTSKLNNGLRVMQYPLRRSMPTLDLDTGRLSMCRLINETVLIYAKEKLFNLKEKLTRLKPYTYVEVTGGNYPKIDYWLFEESEHPEEECLTVHVNLFTGKFVLTLPSFKCKDMLEKLADMLNNDAPNKDLEVSIRDLKMQFLVNRIKKVYAEIKLPLIKENIDLKDVNITCDDDRRIFARITNTDSFIVTQLVANKDENEILFNFFVYEKRKKILTKYFSFYGDEINIGNKKLNKAGSLWERSIEGLGNNVQMFSQTFTKYIGKRDVWIGNYKNLLSSCYVILHEWQLNAISKAYSKGSCGGRDIKRECNNVPYLTLNSTKTLSVCGTGKVLPYEKCFMRMDDRWCYQKPGAYTVELFIRNVALKVDYYVNCPARENLSHKYGVKGTTICIPYNIYWLYPSDFTEKIAGILASERCRILKFYKLLEDIAPHYYKFFNQYCSVKHLSNYKIVFAYGEDRKYLLYLMFYGSTAEYYKFGFGQDSSINYVNDTGSDVTSPWKKGFNAHNNVHEHLLKWKLDKKHLHHLLLYVIKTCTPISILYNINIPQMYSGVFVNEMVNRNYQMKKLAPARLVAIDEYHIRLIFADAVVEFWIGSEDNVLICDVSKDSFKISGLHSVIYTYSSEMKLYNKPFLEMTNDECDRFFEVRNEHFQVNSNTLKKLCLNVESGNQYGVLIEYLHSQHIINHIKLLTKVYSLEEAECPPILNFFNISTTKGSVSFNVQYLLLDTETRDHNNINTIIYIDTNYFTLRIILDIDAGFPVQESLIQISQKYFEEIICYNYNNLSFFGFFKLLLTPSQDALNAVENIFRYELENTISHNRSSVSIKWDSENSRSGQNVNVLNSFVESNFDEGYVLIPVKITDVVKEKRTLLNTNVFHLKYHYHTGLVESTDDEEVYPNLNSYLLTYSKEARTYKKDPVLLSIQNIIKNYIPVLKS
Length1256
PositionTail
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.227
Instability index40.00
Isoelectric point8.49
Molecular weight146221.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04336
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.01|      37|      39|     743|     779|       1
---------------------------------------------------------------------------
  717-  771 (60.72/36.14)	IYWLYPSDftekiagilasercrilkFYKLLE.DIAPHYYKF.FNQYCSV.KHLSNYK
  772-  808 (44.15/24.11)	IVFAYGED..............rkylLYLMFY.GSTAEYYKFgFGQDSSI.....NY.
  809-  838 (36.13/18.28)	.VNDTG..........................sDVTSPWKKG.FNAHNNVhEHLLKWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.10|      26|      37|    1081|    1106|       2
---------------------------------------------------------------------------
 1081- 1106 (46.40/28.99)	PVQESLIQISQ..KY.FEEIICYNYNNLS
 1117- 1145 (34.70/19.79)	PSQDALNAVENifRYeLENTISHNRSSVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.18|      13|      36|     577|     589|       3
---------------------------------------------------------------------------
  577-  589 (23.44/16.12)	SQTFTK.YIGKRDV
  614-  627 (19.74/12.29)	SKAYSKgSCGGRDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.20|      37|     222|     427|     466|       4
---------------------------------------------------------------------------
  427-  466 (59.57/56.89)	LPSFKCkdmLEKLADMLNNDAPNK.DLEVSIRD..LKMQFLVN
  654-  693 (62.63/49.45)	LPYEKC...FMRMDDRWCYQKPGAyTVELFIRNvaLKVDYYVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.76|      13|     132|      23|      35|       6
---------------------------------------------------------------------------
   23-   35 (22.03/14.27)	ISQELIVISELLP
  159-  171 (22.73/14.96)	IYSRLSVISSILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.96|      12|      71|     213|     224|       7
---------------------------------------------------------------------------
  213-  224 (22.63/13.18)	KILIEQYDVGYG
  285-  296 (22.33/12.91)	KLIIEKYDQDGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.08|      46|      64|     964|    1010|      10
---------------------------------------------------------------------------
  964- 1010 (74.60/51.80)	FFEVRNEHFQVNSNtLKKLCLNVESGNQYGV.LIEYLHSQHIINHIKL
 1028- 1074 (72.47/45.74)	FFNISTTKGSVSFN.VQYLLLDTETRDHNNInTIIYIDTNYFTLRIIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.27|      13|     319|     590|     603|      11
---------------------------------------------------------------------------
  590-  603 (23.00/17.60)	WIGNYKNLLsSCYV
  913-  925 (26.26/15.22)	WIGSEDNVL.ICDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.62|      26|      41|    1165|    1190|      15
---------------------------------------------------------------------------
 1165- 1190 (44.38/26.62)	FVESNFDEG.YVLIPVKITDVVKEKRT
 1207- 1233 (40.24/23.46)	LVESTDDEEvYPNLNSYLLTYSKEART
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04336 with Med14 domain of Kingdom Metazoa
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