<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04334

Description Uncharacterized protein
SequenceMANSLENYKIPYWKSENYERRGIRKNSINRSFDIFYQDAMQDEDNISSIERITNGYVSNSLPHEYDSLILNQRNKISENYIDDTTKKAHVFFDRLIEKRQFDSSKSHRKVLMPKVFQVSEWNYKVPKNQNMSQFFENLAKEKDLFSLVKKFPSLGLKENFLEYLYEYNVPVLRGIWFIKILAILKATQTEDGKTPKKSQAQQTALEYVQCLISGYVIYTFKNLYTNGRCDEKKIEKWNYFALLIKHMFEEGVLDRQDFLTDVIDLLNIYVDYKLEDSTKFRMLFLFVSQFSNYITQNIILARRMAFVICKRLRKYHLDYMNICGRPITCPEVMIELMKCQKHRPIILGMISMFYTIINECIQSITVKYITIDKKFTAISCYKDLTDTPLQYLTCRIDVMCEEANLLPQNMVNLMRKKIEEFKRRSIDMKYNLHNVISHDNNCSEFSLMILKIFSILDGIYLVNQINMKKIYESIFNLETNIDKEIEILIKLRIIIHWCITSQRSGSYRVIIVVKLLSLYIAGKKNPIKMMISILNDYLCTEGPQLGYCNFGYEFRNVILLLNDLQQYGILKYEDLLNYWISMGKININECLWVKTLKYVYGENYERDLHPSWNRHIQMSSRYALMFYRRDSEKHTLINIETTTMEERIFLQMPIIPSIENRDIILFRDNIIYGISILRKERLNYLKEVARNIIKVWKKFYYFKIRINNGKSYFYEYHDIKRYNDCGDVLKIFRRQTYYDQTLITYWVGNDFKNCIKEFIENTNNILPGSDGLDYILRMFCISMNIGGMIEYAVGLLELISKLEDTMATRGYNLISGMITKSYAFTIVGYLSEHTNYFLFHKNVVDILNGLFKTIENTIILENYPRTCYDTSIGMFICYCKNFLVREGIAGCNNILGCAKHFSKLYPSPFIEIKLDVPKMRAKKLFFGKYLRVSPQGMSITEFQYLSKKINKCGILSRIEFIMGALQTVKELGRDINKISMLANYVGNVSVQLGMENEWLSVISEMCSLTSIPNTLYTGVHRTVNVGRTMTHYAISSFITILGAKYVFRPCELIKNLIKTTLISVFKGSYLRSRHGYEKVILATLICTKLLTGYHDPFKLPRGYSGISEVKRPAVRRLADFKACNVLFNHEFNEVIFKFIQLLSFANRPIRKVKAKRASKRIRINHLFKACLLCLSEQPWFYQHMKLSIFQTNLCTLNNENNLFKKYKITGTLLNFISRERGDRQNKLQILSCAEKLSKQSFIEKTLESLNIWNFRSVLLNLFGMVNDIVRNPSKSNYARKIYNCNEAIADIAEGIKNIFIAPSNTYGKRIIFKTDTYFRLKDVSNLWLMEYLISEFPKMTVHNCSIKFNKMSVIPLSKSVFMKLSSIVTESYSKNDYGKKTEQISHLFHIPPFSKLMQTLANAEPLCSHALLQGVYSYLTNIVKEFNTRRILCPQLSKEKDGIILRVLLVCGMIDQILTMPAVEPWAYLLWQLLYLEIISKEREEKYYFICYEALSTILFISTFKIQQRHNEKLHYRTRYKAYNHFCKKIRRECQDRPFPIEKMELSQLLPLPKRTFDYIIFDYYHKAIEKIHNSLSIEGPKEDGVKLNSRTGYYPIDKIKLTTFEIIPSFFHENLGRRPINYSFYQAQLVDYNPRVELNVFTKLLFHSHHRIFPKVPMFGGNNVLKNSIFYQPPQIEYDNKEEKRKHSPLRELINMTSKPITENSTSKEQFKSNATNKLTSSPKKDLQEKNVNVGNSNNLKNQNFDLVKENEMKKNLNPSQQVFNGNGPNVPISQQHSTQHVNQNQLVSQNSNNENNNYNLSQSSSATQKVLKRSSSPISGMSVKKRKDDSENIPLPSKVTQQNAYINMNPNNMLPRPPTNNYMQPHGTQKIMTSQPLGIPQHNFQQSNQMQMTINQQPPMSSNILNSNDQQRMPQQVKTMMNPQLRGNGIEQQRLMHQNPQQQRQNLSMHNFMNSQQKGMLPGERQNMVGGYENANMLKEMAQQRNNFGSNMPHQQQYNVPMNNQNLNQGPMMNQFQINQRKEMLYRNAQQHNQMQFQDPNMARLYHQENPQQPLNGNQMFPR
Length2065
PositionKinase
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.402
Instability index46.75
Isoelectric point9.40
Molecular weight242416.31
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04334
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     165.52|      41|      52|    1708|    1748|       1
---------------------------------------------------------------------------
 1708- 1741 (47.75/26.40)	...................SKEQF..........................K..SNATNKLTSSP.....KKDLQEKNVN..VG.NSNNL
 1742- 1795 (47.88/26.49)	KNQNFDLvkenemkknlnpSQQVF..........................N..GNGPN.VPISQ.....QHSTQHVNQNqlVSqNSNN.
 1796- 1855 (42.91/22.86)	ENNNYNL.................sqsssatqkvlkrssspisgmsvkkrK..DDSEN.IPLPS.....KVTQQNAYIN..M..NPNNM
 1860- 1891 (26.98/11.22)	PTNNY..............................................mqPHGTQKIMTSQplgipQHNFQQSNQ...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.57|      48|     108|    1896|    1944|       2
---------------------------------------------------------------------------
 1896- 1943 (92.59/55.51)	INQQ.PPMS.SNILNSNDQQRMPQQVKTMMNPQLRGN...GIE.........QQR.............LMHQ.NPQ
 1944- 2007 (32.28/14.54)	..QQrQNLSmHNFMNS........QQKGML.PGERQNmvgGYEnanmlkemaQQRnnfgsnmphqqqyNVPM.NNQ
 2009- 2054 (76.70/48.33)	LNQ..GPMM..NQFQINQRKEMLYRNAQQHN.QMQFQ...DPN.........MAR.............LYHQeNPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.01|      25|      46|     296|     322|       3
---------------------------------------------------------------------------
  296-  320 (45.31/38.10)	QNIILARRMAFVICKRLRKYHLDYM
  661-  685 (42.70/27.44)	RDIILFRDNIIYGISILRKERLNYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.48|      88|     145|     848|     936|       4
---------------------------------------------------------------------------
  848-  931 (143.80/103.12)	.................N..GLF..KTIENTI.ILENYPRTCYD.TSIGMFICY.....CKNFLVRE..GIAGCNNILGCAKHFSKLYPSP........................FIEI....KLDVPKMRAK..................KLFFGKYLR
  933- 1071 (82.61/56.47)	SPQGmsitefqylskkiNkcGIL..SRIEFIMgALQTVKELGRDiNKISMLANY.....VGNVSVQL..GME..NEWLSVISEMCSLTSIPntlytgvhrtvnvgrtmthyaissFITI..........LGAKyvfrpceliknlikttliSVFKGSYLR
 1072- 1162 (105.07/69.63)	SRHG...................yeKVILATL.ICTKL.LTGYH.DPFKLPRGYsgiseVKRPAVRRlaDFKACNVLFN..HEFNEVI.FK........................FIQLlsfaNRPIRKVKAK..................RA..SKRIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.32|      81|     186|    1263|    1391|       6
---------------------------------------------------------------------------
 1263- 1361 (107.93/157.59)	GmVNDIVRNPSKSNYARKIYnCNEaIADIAEGIknIFiapsntygkRIIF...KTDTYFRLKDVSN....LWLMEYL..IS.EFPKMTVHNCsikFNKMSVIpLSKSVF
 1414- 1504 (121.39/66.78)	G.VYSYLTNIVKEFNTRRIL.CPQ.LSKEKDGI..IL.........RVLLvcgMIDQILTMPAVEPwaylLWQLLYLeiISkEREEKYYFIC...YEALSTI.LFISTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.86|      29|      35|     545|     579|       7
---------------------------------------------------------------------------
  545-  579 (45.17/53.34)	LGYCNFgyefrNVILLLNDLQQ.YGiLKYE.DLLNYW
  582-  612 (49.68/36.40)	MGKINI.....NECLWVKTLKYvYG.ENYErDLHPSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.40|      25|      35|    1190|    1214|       8
---------------------------------------------------------------------------
 1190- 1214 (43.74/27.18)	QTNLCTLNNENNLFKKYKITGTL..LN
 1224- 1250 (36.66/21.47)	QNKLQILSCAEKLSKQSFIEKTLesLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.72|      15|      37|     321|     335|       9
---------------------------------------------------------------------------
  321-  335 (29.44/16.62)	NICGRPITCPEVMIE
  358-  372 (26.28/14.08)	NECIQSITVKYITID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.18|      37|      37|    1520|    1556|      10
---------------------------------------------------------------------------
 1520- 1551 (53.22/30.11)	..........YKA....YN.....HFCKKI.................RRECQDRPFPIEKMELS..QLLP
 1552- 1609 (41.69/21.90)	LPKRT...fdYII....FD.....YYHKAIekihnslsiegpkedgvKLNSRTGYYPIDKIKLTtfEIIP
 1616- 1655 (21.27/ 7.36)	LGRRPinysfYQAqlvdYNprvelNVFTKL.................LFHSHHRIFP.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.59|      26|      41|      76|     116|      11
---------------------------------------------------------------------------
   76-  101 (45.95/49.43)	ISE.NYIDDTTKKAHVFFDRLI.EKRQF
  118-  145 (37.64/13.41)	VSEwNYKVPKNQNMSQFFENLAkEKDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.27|      16|      34|      22|      37|      13
---------------------------------------------------------------------------
   22-   37 (29.26/19.92)	GIRKNSINRSFD..IFYQ
   55-   72 (25.00/15.70)	GYVSNSLPHEYDslILNQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04334 with Med12 domain of Kingdom Metazoa
Unable to open file!