Description | Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MEVSNPEQSNQKIPQIDPTVHSKTCLSEMHSALTDLMESFEVPNSSNINKKVKTVESRLELFKSSLDQIPDIDHNLLYQEKKIKDLQRCLELKKNLINRLYALPKKLEDIKPGKGIDEIMKKKQQLQNETKT |
Length | 132 |
Position | Middle |
Organism | Strongyloides venezuelensis (Threadworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.827 |
Instability index | 47.54 |
Isoelectric point | 8.46 |
Molecular weight | 15273.47 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364145 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04331 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.88| 28| 29| 49| 77| 1 --------------------------------------------------------------------------- 49- 76 (46.83/27.02) NKKVKTVESRLELFKSSLDQIPDIDHNL 80- 107 (43.05/20.69) EKKIKDLQRCLELKKNLINRLYALPKKL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IDEIMKKKQQLQNETKT 2) IDHNLLY 3) KIPQI 4) LQRCLELKKNLINRLYALPKKL 5) NINKKVKTVESRLELFK | 116 72 12 86 47 | 132 78 16 107 63 |
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