<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04330

Description Uncharacterized protein
SequenceMFNSTKSYKVPNWNTESTEKRPIRKASRGKHFDIFPQDSKQDEDNLSSHDRIRKGYLYPQHSYEHESLIYNQKTSKIDAKLDDTIKKANNFFITVMKKRANDNPKSGKRPLVAKAFQVSEWNFLTKIPRCPSIPQFFEDLSKGKALYGLIRRFPQFEKNEDFLKYLFDYRVPIVRAIWFIKMVAIFKATHIPVVTKPPKKSQALQSALEYVQSLISGLIIHTFNNFYNKDKSEDEKNDRWNYFSLLIKHMCEEGVLDRQDFLTDMIDLLNKYQNYPLDKPQRFKILFLFVSQFIHYVTQNIIISRRMAFIICRRFQKYHYDYMNVAGKPITAGEVLSEISKCENHRAIINNMTGMLYSIITECPQSLPRKYMIYVKKFTGIKIYDELGGSPLDELTCPFDIMCREGNLLPQNMIEIMKPKIQEIIDRSIDMKYQWHEVISGKTYCSEVVKMILKMYETLDNVFLLSDKEIVNLHEVIFKNAMNMDDEIEIVLRRRMLIHWSITSQRDGTHRVSLVVRLLQVHLKDTQDKCGTMINILNDYIYSEAPKLGYCNYGYEFRNFILLLNDLQLYGIIKYKKLLDYWIKKGRIEIDNCLWAKTVKYIYGENYERDFHPSWNKNISMSSRYALQFYRRDSEKHTLLNLEGVTPEERIILQLPIIPSIQNREDIHFHDRLMFGISIQKNEHINYIKEVARGIIKVWKKLYYFKVDINKSNVHFHEYHDIVRYKNCGDILRRFRRQTYYDQTLITYWVGDNFKEYIVNFIENTNNVLPGLDGLDYILRMFCISMNIGGMINYILEILPKISKLEDIMLGRCYNFIPGVITKGYAFVIVAYLSEHLMYFLNHPNSIGVLNGLYQTIENTIKLQGYSRTSYDSSISVFVSQCKYYLLVHGIAKPNDIMGCAEDFEKLYPRKSIETKIEQPRVQPKKHFFAKYLNSSPTLLPFNEIRSLIKGVNSNGISCRISFVLSAINIIKTLGRRVNKISAIANYCANVSALLNLESEWISAIVELCSITNNPHSMYRGVHKIFNVSRTTTHYALSTFIAILAARFTFRPHELIKKLIKSSLIYAFRGAYNRSKYGYQKVILSALICTKIVTGYHDPFKLPRGYSGLAEVKRPIVKKLSDFKACNVLYPRELDSVIFPLIKIFTTINRPMRKIRRNRAPKKIRVSHFLRACLLFISEQPWFYQKMHFGILNRSGDWEQFKKFLLKNFGLPGILLNYISRRKGDRRAKLMNIGCAENSSKKAYIERSLLSLNVWNFKAVFWDLWGIIMDGTRRPQMKNYPQRIYHCEQLITEIAKGISDIFTNISNSFKRHADFKTDTRFRLEEVKNSYLIEDLVMMFPKIWLPRTRSAYYKMQVTTLPSAVLKEFTSIITSTYSKTNYALRMEQMSHLLHITPFLRILQTICNSEPPQTSYALLQGLYGYLSSLIDDFDSRRLLRSSLISDKEGLILRVVMIAGMMDQLLTMEKIEPWAVLFWQLLYYEVFHPEREGKFYNICYDALTNVLFNSAFKFQSRHIHIEHAYYRARYLTYMQLCKRLKKEGQDRPFSADKQQLSQLLPLPKRTFDYISFDHYFKMVGKARNAYTVNYLSSNEMKLINRTGYYPVEKIKLTTFETVQSFFHELLGKRTVNYSFYSAVLADYVPKVNIDLLIRLSFHDHYRLFPRAPIIGENKELTKDFMYRHPEVEITALPKEDKEKEKIKLMPPRPLMNPSISTNPTIASNPQIAAILSHTTDKSISSQGGIIKDSNIPIDVKQSLSDMPKIAKEVIHDINSRSTPKNVPNPMTTLQNKPPNLIDQVSHPIDMPNQSSSISKHRNESPIKNEIMSQQIQQNSIQQQSLHNRHLPPNGQQQLIQPTLSNVNKPPPPYNSSQHPMQKPFSSQDVRIGIPSTDVSGSNINQNKIHFNDESTYSRDMSQQEPMQIDSQPPVLVASGNPSKGNKRKPHPGTGSSMKTVSKKRKDNKGNDLLSPPNLLENQPTLGQHGQQPIGIRTFDNNQQNQQLPNYGNQGNFGSQGNIGMSQNMAHKNNMPNQGNIPNQGGIHGQGNIHNQSNIHNQRSLPNKSTMYNQGNVSQQSNLHEQGNHLNQNPHHQSQIIHQSQSNHLPQSTPHQQHQTSQLNQGPNNIGIGQQPQSSNMFINNSGPTKAQQQNQPSSRLPQQNVNSMNMGRNQQTGSMNVLSHQQPSSMNHPSHPLQQQSTLNMVVNQKSNTINVGSHQQQGNIMGMSNPQHGNVSNSQMSNMNISSHSQNSSIGRSNQPPQQPPPPYNMSTMGQQQSSSMNVPNTQQQSNSLPIQSGMGGSSMNIPSNQQRNMIGMSDGRINNPISISGNQQNTNINMSSGQQNMSMDMQTNQQQPSGMGKSNILQQVLNNPNSTQNIPQNQQYSKNIGMTSNPQQQGNIQSQQQQPKSMIPPSNQQSNIPPHIQQNISSGMRQQQPQQTAPPMQQGVNQKMYGQSGGGMTKPMGKNMMGLGMKPQNLPGPQPHQQQQSQQSSGGSMMSNMGNTMSGGMSSNMSSSNNMVNNLSSNMSGTIHSNMTNQQRMMHQNMMSQQSQQQVPQSRQIQESGISLGQQQRPQQIGNSQQQMSGTQGHMSGQRGQIHNPQQPPISGMQQQMSGHHQQIPSSHQQKMHNQSQSSQQQVGNPQQIMGNPNQSIMSSSQQQWNLQHPQQGSMGKEVQGMNTGRMPPINPGMVRDRGNLRAGSEAPLEDTKKILKDMLKQKTNPGPVLHLSNQQHQQNMMVNQQGPSQHQHMGMGGQMQHNQGSIMNTYESNQRQEMLYRNSQQHPNVSMGMINQQQPQQGSQTQQQYNSQQMYP
Length2807
PositionKinase
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.643
Instability index58.75
Isoelectric point9.61
Molecular weight322327.50
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04330
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.28|      21|      21|    2033|    2053|       1
---------------------------------------------------------------------------
 2042- 2065 (28.66/ 7.92)	GNIHNQSNIH..NQrslPNKSTMYNQ
 2593- 2613 (25.77/ 6.20)	HNP.QQPPISgmQQ...QM.SGHHQQ
 2650- 2667 (28.85/ 8.03)	SS.QQQWNL...QH...P.QQGSMGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1261.10|     146|     146|    2190|    2335|       2
---------------------------------------------------------------------------
 1719- 1826 (82.02/24.05)	...................................SN.PQI.AAIL.SH..T...TDKSIS..SQGG.IIKDSNI.......................PIDVKQSLSDMPKIAK..EvihdinsRSTPKNVPN.........................PMTTLQNKPP..................NLI...............D....QVSHP.IdmpnqssSISKHRNES.PIKneiMSQQ
 1828- 1900 (98.02/30.29)	QQNSI...................Q.QQ.SL.HNRHL.PPN.GQQQLIQptL...SNVN..........................................KPPPPYN.....................................SSQHPMQKPFSSQ..............................................D..V.RIGIPsT.......DVSG....S.NIN...QNKI
 1903- 2041 (149.00/50.17)	NDESTY..SRDMSQQ.EPMQIDS...QPPVL.VASGN.PSK.GNKRKPH..PgtgSSMKTVSKKRKD.NKGNDLL.......................SP..PNLLENQPTLGQhgQ.......QPIGIRTFDN.....NQQ...NQQLPNYGNQG....NFGS..QG..................N.I.GMSqnmahknnmpnQ..G.NIPNQ.G.......GIHGQ...............
 2068- 2187 (152.55/51.55)	...........VSQQSNL.....H..EQGNH.LN.QN.PHH.....QSQ..I...IHQSQSNHLPQS.TPHQQHQ.......................TSQLNQGPNNIG.IGQ..Q......pQSSNMFINNSgptkaQQQnqpSSRLPQQN...VNSMNMGRNQQ............................................TGS.M.......NVLSHQQPS.SMN...HPSH
 2190- 2335 (276.79/100.00)	QQQSTL..NMVVNQKSNTINVGSHQ.QQGNI.MGMSN.PQH.GNVSNSQ..M...SNMNISSHSQNS.SIGRSNQ.......................PPQQPPPPYNMSTMGQ..Q.......QSSSMNVPNT.....QQQ...SNSLPIQSGMGGSSMNIPSNQQR..................NMI.GMS...........D..G.RINNP.I.......SISGNQQNT.NIN...MSSG
 2336- 2438 (151.16/51.01)	QQNMSM..DMQTN...........Q.QQPSG.MGKSN.ILQ..QVLNNP..N...STQNIPQNQQYSkNIGMTSN.......................PQQQG....NIQSQ.Q..Q.......QPKSM.IPPS.....NQQ...SN..............IPPHIQQ..................NI....S...........S..GmR..................QQQP.QQT...APPM
 2439- 2531 (116.23/37.39)	QQG........VNQK.......MYG.QSGG...GMTK.PMG.KN.......M.....MGLGMK....................................PQNLPGPQ........................PHQ.....QQQ...S.....QQSSGGSMM...SNMGN..................TMSgGMS...........SnmS.SSNNM.V......nNLSSNMSGTiHSN...MTN.
 2532- 2696 (130.66/43.02)	.QQRMMhqNMMSQQSQQQVP.QSRQiQESGIsLGQQQrPQQiGN.SQQQ..M...SG......TQGH.MSGQRGQihnpqqppisgmqqqmsghhqqiPSSHQQKMHN.....Q..S.......QSSQQQVGNP.....QQI...MGN.PNQSIM..S..........ssqqqwnlqhpqqgsmgkEVQ.GMN...........T..G.RM.PP.I.......NPGMVRDRG.NLR...AGSE
 2724- 2802 (104.66/32.88)	NQQHQQ..NMMVNQQ......GPSQ.HQH...MGMG......GQMQHNQ..G...SIMNTYESNQRQ.EMLYRN..........................SQQHPNVSMGMINQ..Q.......QPQQGS..QT.....QQQ...YNS...............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.76|      24|     104|     674|     697|       3
---------------------------------------------------------------------------
  674-  697 (43.35/24.38)	MFGISIQKNEHINYIKEVARGIIK
  781-  804 (45.40/25.89)	MFCISMNIGGMINYILEILPKISK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.06|      22|     100|    1259|    1292|       4
---------------------------------------------------------------------------
 1224- 1251 (27.92/30.08)	GDRRAKLMNigcaenSSKKAYIERSLLS
 1271- 1292 (43.13/19.32)	GTRRPQMKN......YPQRIYHCEQLIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.17|      26|     100|     818|     853|       5
---------------------------------------------------------------------------
  818-  843 (46.12/44.35)	PGVITKGYAFVIVAYLSEHLMYFLNH
  864-  889 (46.05/22.59)	QGYSRTSYDSSISVFVSQCKYYLLVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     195.71|      59|     102|     135|     196|       6
---------------------------------------------------------------------------
  135-  169 (46.83/23.42)	.....................................................................QFFEDLSKGKALYG..LIRRFPQFEKNEDFLKYLFDY
  172-  275 (73.84/48.86)	PIVRAIWFiKMVAIFKATHIPVVTKppkksqalqsaleyvqslisgliihtfnnfynkdksedekndrwNYFSLLIKHMCEEG..VLDRQDFLTDMIDLLNKYQNY
  276-  322 (75.04/40.06)	PLDKPQRF.KILFLFVSQFIHYVTQ..........................................................niIISRRMAFIICRRFQKYHYDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.41|      15|      39|     716|     732|       7
---------------------------------------------------------------------------
  716-  732 (25.22/20.96)	FHEYhdIVRY.KNCGDIL
  754-  769 (23.19/11.58)	FKEY..IVNFiENTNNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.63|      29|      39|    1638|    1666|       8
---------------------------------------------------------------------------
 1638- 1666 (51.80/34.40)	DYV...PKVNIDLLIRLSF.HDHYRLFPRAPII
 1675- 1707 (41.83/26.19)	DFMyrhPEVEITALPKEDKeKEKIKLMPPRPLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.17|      19|      40|    1162|    1180|      12
---------------------------------------------------------------------------
 1162- 1180 (33.62/21.62)	KKIRVSHF.LRACLL.FISEQ
 1202- 1222 (24.54/13.62)	KKFLLKNFgLPGILLnYISRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.05|      28|      42|     953|     981|      16
---------------------------------------------------------------------------
  953-  981 (42.78/36.41)	NSNGISCRISFVlSAINIIKTLGRRVNKI
  998- 1025 (51.27/38.83)	ESEWISAIVELC.SITNNPHSMYRGVHKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.49|      13|      35|    1370|    1382|      21
---------------------------------------------------------------------------
 1370- 1382 (22.94/13.42)	IITSTYSKTNYAL
 1403- 1415 (25.56/15.97)	ICNSEPPQTSYAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.63|      19|      34|    1525|    1543|      22
---------------------------------------------------------------------------
 1525- 1543 (33.99/23.21)	RYLTYMQLCKRLKKEGQDR
 1561- 1579 (34.64/23.82)	RTFDYISFDHYFKMVGKAR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04330 with Med12 domain of Kingdom Metazoa
Unable to open file!