<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04327

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTKNHKDIFDDYSNLFHKDSIANDVTLEDCHTNVLPLADISKLKWKCFRTNSRSTTKCKEAIKADLVLKAYSLCISENYICLWRRIPPDDFDNDYPKGEFTLRSAKELWVFWFDKKEPRNLASYTCDLVVRDEYDGDHQNQIDVVRYDIRCLLFRAIHNLIERSLFTMGQKRFGKWFVATGTKEEMKQSMPQRNYSLAYGFSFFVHGEIMVCATINIQRQPLMCRLGLLDYFSKKTVPLILGPHGIRATLVADQIECVRREVVNISTKYKRDILVGKQYKEIETIAEEQYNDWRGFYPLPVYDSEDIKYRVPTVSEILPRMTLVEIDNLKMLWPTEYIGIIMDEYVCNGDRKCFYEKVVDEDQEVATIMANSKENSDLKLDNTSNRVMFDIERVDLECFCRHHNEDTDQNGRIFEDMIISSEYAVLPENDVEKPISNITSLPMTENKEKDEKFENAMSFLMEIDNELKKEESKRMEIDDDDDIEKFLNFDNSIKGPNSKSPEKNSTDSKNEKVDVNEKKDGDIKIIKDKNDTIEEVKETVKIIVPKNVEPALGNKWRYSNYCGKTDCVCPLCFKLGKMMLINPSKKFSKNSTLKEELMNGDKEKENEPNVSTSYEKLVIQRLEAQTAIPKLSKRIPAPEKRVLEGKPIYGIGNFTLRDHTSNFQTMKYGDPKIFEEMKCLPEFNATKGTTSKELFPKFTPLIKTKFEYFRKKKYLLGRISHKKGKKKIYHTNNMMARLCLTPPTSRRNRLINRTRKRYLFPKEDTLMARDVTFYDKSIQHDTNEMLNSFISCIYDINSTKKYDYKIKIYKDIKISPSMDLKENYIDLLFQQFDNNDSDISGDTIYKCQLYKIKEKFLLNREESISLDSLDPFKWHSEGKETFESYYNLDDNKGTLNHVPYYIIMNEYFYVIVDRKLERTKSEPNSMFSNERLFPISTDNDLINNRKYFVDINNENEPQCDVVQKYFDNYLLNTKDECLDFNNKLNTFDATYEDKLPKTSFTKELVEGIYNGNIINELLESENEKEEDNNVNNHNKIVEIEDVEMASNFDVDEFLKEAGDSNSMEVDDSLLTTFNKKQNERDGVNLNQVENNPINSSSIDEDDDIVESILNDYRVKYDSNIDHFRMIYKNFICERDNTIEDADKENNSELSIILENINKEIGCSSTSIDCDTVTKSRKIKTYILGKNVFPGYLNDFCEWNRFFRDVDYDNIVPERLRPKKYDSFDLYKNTKHSCCDPFKQVLDEEKGVYGIPESYIRKNVPKVSVLAIIKKIVENVDIQKQAHERYINQLVKTSWKNIPLYSYFDSKNFPPKKILTDNFKNTIFIQEEKYIRNTNPSSIQEIINTVNEYKNDDGYKKDKTCRLSKSFEMCKADQQSKRNLIRHRYERMLRAFEISNRFCPVRTADDSDITHMMFDYETQPSTMSMHNMSQHHPQNNDFFNHQQNFNIMDDFHGMGNNFNMNNSQHNQGFYNGPINYQSRHSNQFFSNQSGYPSLHSSITPSFDNFMNDNFDQISNHNNLGSWNQMPHSNFPSRNSYQQNYLPNQNNVFGGNSNYGRNIPTTLENDEEQTCIMKENETTIKAKNFKTLNKNNRYYHTISDKFVGKNLLLKFNFRETIASETTNALNQNQYYTFTIDGRLEGPFMSDSYDTINEDSTINEKKCFAKKFESQICINKNLKHIFTDEMGSFNALQHILNNYIFHNLYVEPIFYNTNYKKYTKRHYISKPAIESEQLTITSNDKLFEFNDLTYSDNGAKRRKIDLNLTNQENIHDMEINSIPFFIEERSNVVRKQVNSYQGGSIFQIFPCKVGYSQVDYSNETSNDIEKWSEEMYKRINQEKSLLSTNISNPYNVNIRQLQYSIPHYSESYNDLITKYNNAMEIDKNYFVYNYDPETLENYRTDEFIKARYSSLNILFGSKNNINEIDEDGFVDESLLGGMNNLDNNDQELIKSNKYIEHDYYSLMNEIAFRMVEKGDSEDFRNEVNYLYNMNRSPSLLSVVSFSGSDDDNESIPPSKYNLNFSQNYFTYNSSNQHNPLDYNDVDEIFEINDLDSSYEDDSNDSNSDGSNDSTDYDNSPINAFDEEMEAEIEKELKETEFNSSPNDSSEELIDSDSESESEVFNYTSNDDHFMVENCEKCLKDNYQPLAVCRQLQNNWSGVNLIVQSIIPRYTNINDIYQLCLIANSQELFDNLRDSILEKITKNKLARESPDYYKIMRKIKEFGYTLPYESYILYREGPVVSYSHYLIHNDIDSYIHLPNCECCECLQLPPIPSYIDLDDPTSKNPYLFNYRNPKFINKGSTIYNISSTSKRYIPPMMSHHAFNDSLQLNNKLSCNIKYMNVIKSLNDKIDRTVRNKKYCNNGKIMGKEYPDTAAIIEVERNIANIKVLNASRPPDFLKLNEKGNPVTRGAYERLVTKKQYQKMKTKRLSLLKFKSPKIYFFKGYDSRSHEREGLYNNIISSSDRPFQYPDVIVEDSEKEDEYDEYYDLPSAHSYSEECPILENHADLSSNLLDSSSCNTSGINLLNPLTPGNPMTPSMNPLTPQMANPMTPGTSTLDGSQNINALTPNPGSISSSGPPSNYMNPGSNNYPNPGSNSYSNPGSNSYPNPGSNSYPNPGSNSYSNPASNTCPNPGSNSSVLQSIISQPNSQGNPQHFLPGNISSPSSFHGSGQIGQTMMQSPIMNSENQFMPNSGNYNFNRQMNQSCYNPMRDNYNSGMFQNMNNQNVFMGNDKHNVSYNNDGTNALYDHNQYNSNINQMASGDSMSNMRPEMNSNMNQMINSHYNNPMQQFNNSNNLPDRNSQHYPLETMNHQTSGNINQGYINSGSHHMAGGNQRVNYNNQMPDSQYYNKLPNMNYENNSQNFINNRNSYGDENNPNEVPFDSTFNNSVGNQHHQISVNQGNEMFNAKNISFNQSPGNNYQMNYNQNNYMDSEGNVQMFNNDDHEGSSMDGMYDDLLHPHSSRDNQQTFDNSPMPLLHNESNFAIEPLIIDSNTEYNCLYYKMEPETIPLASTLPLVETEKLAIDTNYILPMEPNKKVDVIRKDIISRREIKKDSIGISLLLHDSVFELHYDIIFDGCPICSCNSNIMSDDYGMYLRPPGILNKKGVTKSEWSGFYLAGDKNKCKCGFSALRHKLFSYNSGLFKEDAEEGSGLGAIYEQHPTKYHTFYNQLTEYDLSFINLIRIQSLNREMGAQIHSIESMLTKCNPPLTNAISNKYLSKCSNYMFSQVDINEKEHAIYNSFKASIEDDNESHLCIPNRNRKLIDYPSFLHPWSIQFPNNAKDATDADCFIILDNVSTFFKTLIHSTQCFGQEERKDVKTLTWSEFFKSATRSSKVQDECLQAPEPIPSVILASEKDLISSAPQIVCNWEKLGLSPIDQPKDVLYFVVTPDNDFVVEKTRLYFHELSKIYENYKLGRHIKLSKDIVEDGIFRVPIMIPDNCKIEGDSEQKYYDLFNEIISDKEYLDKMKSYAAFIEKQVYQFFEYNDILFDRRAYWECVKQELSGIPNISHDLSTTASTISLQSIQDTTSVNFPPGYYDHCSPPNMNRSGTEFDQQKPNSPIKDEDMTEMPHVIVIYIINPFNFGIRINQPEQPKFALISLMRAFNVFLMKLNTTKRFRIQLEVINLQSIMDYAGYLCDKKRNERWYAPDPVYTRNKNFKFSAYEQLRNLSFAVYTHSRVYNTEDVRYVLAKSVTKFGYTSTVLDHVAEDIESGDKIFKLPCNLYRLSSQKRNPIQIIGKSLKRHIEDSVLFVSYCLVEDKWLVVTISDHLGYLLDNCLINLQVTHKDNEIVKYKKGNRILDAISRLWVYIMGVLASETRNWRIVIGRFGRVGHTELKAWMHILSKSNIKRYNTKIKEACNLCAESLNSQSCPIIVSACFVSMEAEHNLRLFSNAVAKHKVMVPPISSNRSSKQKVIHSPDDVSVTHILVFPTTVDLSIDLTQGKDGQEKDDFENLMLDEGNDEIMELMKDGFDDVEDELKTTEPDNNHEENFFNIDAFEADASNQPMAIGYYISTAPTGKLPNWFWSQCPKAKDRCPVHLRNSLHIVTSNILQSDELMLNFKNTESTHPLDSTATDDVLRYVLKTYNALSWLNVDCVTSERRSCLPIHIQALARLCDAVETFMF
Length4122
PositionMiddle
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.724
Instability index45.92
Isoelectric point5.33
Molecular weight477877.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04327
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     128.87|      22|      22|    2576|    2597|       1
---------------------------------------------------------------------------
 2001- 2025 (27.00/ 7.38)	GSdddNESIPP.SK.YNLNFSQNYFTY
 2567- 2589 (40.30/15.27)	GS...ISSSGPpSN.YMNPGSNNYPNP
 2590- 2613 (36.24/12.86)	GS...NSYSNPgSNsYPNPGSNSYPNP
 2614- 2629 (25.33/ 6.39)	GS...NSYSNPaSN........TCPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.57|      18|      18|    2683|    2700|       2
---------------------------------------------------------------------------
 2682- 2694 (21.24/ 6.09)	.....ENQFMPNSGN...YN...F
 2695- 2715 (27.24/10.62)	NRQMNQSCYNPMRDN...YNsgmF
 2716- 2730 (23.65/ 7.91)	QNMNNQNVFM...GN...DK...H
 2918- 2938 (25.44/ 9.26)	QMNYNQNNYMDSEGNvqmFN...N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.95|      17|      19|    2749|    2765|       3
---------------------------------------------------------------------------
 2761- 2780 (24.36/ 8.92)	MSNMRpemNSNMNQMINSHY
 2781- 2798 (23.43/ 8.23)	NNPMQ.qfN.NSNNLPDRNS
 2901- 2917 (26.16/10.24)	MFNAK...NISFNQSPGNNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.56|      17|      17|    1573|    1589|       6
---------------------------------------------------------------------------
 1573- 1589 (27.87/17.00)	KEN.ETTIKAKNFKTLNK
 1609- 1626 (22.69/12.10)	KFNfRETIASETTNALNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.22|      22|      22|    2068|    2089|       8
---------------------------------------------------------------------------
 2075- 2099 (29.82/13.66)	INAFDEEMEAEIEKElkeTEFNS.SP
 2100- 2124 (26.18/10.96)	NDSSEELIDSDSESEsevFNYTS.ND
 2125- 2142 (20.21/ 6.53)	....DHFMVENCEKC...LK.DNyQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      18|      19|    3250|    3267|       9
---------------------------------------------------------------------------
 3250- 3267 (33.78/18.61)	H...LCIPNRNRKLIDYPSFL
 3268- 3288 (28.11/14.11)	HpwsIQFPNNAKDATDADCFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     728.50|     351|     533|     256|     788|      10
---------------------------------------------------------------------------
  256-  460 (158.63/147.73)	...................................................................................................................................................................................................................................................................................................................................................................IECVRRevVNISTKYKRDILVGKQYKEIETI.AEEQYNDWRgFYPLPVYDSE...DIKYR..VPTVSE..ILPRMTLVEIDNLKML.WPTE......................YIgIIMDEYvcngdrkcFYeKVVDEdqevatimanskensdlKLDNTSNR..VMFDIERVdlecFCRHHNEDTDQNGRIFEDMIISSEyavlPEND.VEKPISNItslpMTENKEKDEKFENAM.SF
  461-  690 (193.82/541.45)	LMEIDNE..........LKKEESKRMEIDDDDDIEKFLNFdnsikGPNSKSPEK........NSTDSKNEKVDVNEKKDGDI..KIIKDKNDTIEEVKETVKIIVPKNVEPAlgnKWRYSNYcgktdcVCPlcfklgKMMLINPSKKfSKNSTLKEELMNGDKEKenePNVSTSYE.KLVIQRLEAQTAIpkLskripapekrvleGKPIY.G.IGNFTlrDHTSNFQTMKYgDPKIFEEM..KCLPEFNATKGT....................................................................................................................................................................................................................................................................................................................................................
  791-  988 (164.59/94.32)	...............................................................................................................................................................................................................................................................tskelfpkftpliktkfeyfrkkkyllgrishkkgkkkiyhtnnmmarlcltpptsrrnrlinrtrkrylfpkedtlmardvtfydksiqhdtnemlnsfISCIYD..INSTKKYDYKIKIYKDIKISPSMdLKENYIDLL.FQQFDNNDSDisgDTIYKcqLYKIKEkfLLNREESISLDSLDPFkWHSEgketfesyynlddnkgtlnhvpYY.IIMNEY........FY.VIVDR.................KLERTKSEpnSMFSNERL....FPISTDNDLINNRKYFVDINNENE....PQCDvVQKYFDNY....LLNTKDECLDFNNKLnTF
 1018- 1230 (211.47/ 0.00)	LLESENEkeednnvnnhNKIVEIEDVEMASNFDVDEFLKE.....AGDSNSMEVddsllttfNKKQNERDGVNLNQVENNPInsSSIDEDDDIVESILNDYRVKYDSNIDHF...RMIYKNF......ICE......RDNTIEDADK.ENNSELSIILENINKEI...GCSSTSIDcDTVTKSRKIKTYI..L.............GKNVFpGyLNDFC..EWNRFFRDVDY.DNIVPERLrpKKYDSFDLYKNT....................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.26|      16|      16|    2480|    2495|      11
---------------------------------------------------------------------------
 2480- 2495 (30.60/17.76)	DEYYDLPSAHSYSEEC
 2499- 2514 (27.65/15.22)	ENHADLSSNLLDSSSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.33|      25|      28|    1842|    1866|      12
---------------------------------------------------------------------------
 1804- 1819 (20.43/ 7.44)	.....PCKVGYSQVDYS.....NETS
 1842- 1866 (44.33/28.34)	TNISNPYNVNIRQLQYSI.PHYSESY
 1871- 1896 (36.57/21.56)	TKYNNAMEIDKNYFVYNYdPETLENY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.91|      14|      19|    1428|    1446|      13
---------------------------------------------------------------------------
 1429- 1445 (23.70/16.06)	SQHhpqNNDFFNHQQNF
 1463- 1476 (26.22/ 6.63)	SQH...NQGFYNGPINY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.14|      22|      29|    1482|    1510|      14
---------------------------------------------------------------------------
 1482- 1500 (26.36/12.84)	.................NQFFSNQSGYPSLHSSItP
 1501- 1531 (28.23/22.17)	SFDNfmndnfdqisnhnNLGSWNQ..MP..HSNF.P
 2959- 2975 (28.54/11.42)	SRDN.............QQTFDN.SPMPLLH.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.31|      13|      19|    2243|    2255|      15
---------------------------------------------------------------------------
 2243- 2255 (25.85/11.43)	LIHNDIDSYIHL..P
 2263- 2277 (21.46/ 8.22)	LQLPPIPSYIDLddP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.49|      15|      19|    1657|    1673|      18
---------------------------------------------------------------------------
 1312- 1326 (25.47/10.89)	KKILTDNFKNTIFIQ
 1659- 1673 (27.02/20.94)	KKCFAKKFESQICIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.65|      65|     283|    3359|    3447|      19
---------------------------------------------------------------------------
 2148- 2224 (96.86/61.79)	QLQNNWS..GVNLIVQsiiPRytninDIYQLCLIANSQELFDNLRDSI..LEKITKN.KLARespdYYKIMRKIKEFG.YTLP
 3361- 3431 (97.78/133.66)	QIVCNWEklGLSPIDQ...PK.....DVLYFVVTPDNDFVVEKTRLYFheLSKIYENyKLGR....HIKLSKDIVEDGiFRVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.94|      14|      19|    3086|    3101|      20
---------------------------------------------------------------------------
 3086- 3101 (23.11/17.07)	SDDYGMYLrpPGILNK
 3107- 3120 (27.84/13.59)	SEWSGFYL..AGDKNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      32|    2983|    3002|      22
---------------------------------------------------------------------------
 2983- 3002 (20.81/22.50)	EPLIIDSNteYnclYYKMEP
 3017- 3031 (29.17/13.82)	EKLAIDTN..Y...ILPMEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.35|      16|      32|    2026|    2041|      23
---------------------------------------------------------------------------
 2026- 2041 (30.08/15.75)	NSSNQHNPLDYNDVDE
 2057- 2072 (29.27/15.07)	NDSNSDGSNDSTDYDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.96|      57|     390|    1897|    1955|      24
---------------------------------------------------------------------------
 1897- 1955 (92.51/55.05)	RTDEFIKARYSSLNILFGSKNNINE.IDEDGFVDESLLGgmNNLDNNDQ..ELIKS.NKYIEH
 2288- 2348 (87.45/46.11)	RNPKFINKGSTIYNISSTSKRYIPPmMSHHAFNDSLQLN..NKLSCNIKymNVIKSlNDKIDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.04|      17|      29|    2833|    2849|      25
---------------------------------------------------------------------------
 2833- 2849 (32.99/18.37)	VNYNNQMPDSQYYNKLP
 2861- 2877 (31.05/16.68)	INNRNSYGDENNPNEVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.87|      17|      18|    3447|    3463|      30
---------------------------------------------------------------------------
 3447- 3463 (31.01/21.31)	KYYDLFNE..IISDKEYLD
 3466- 3484 (26.86/17.13)	KSYAAFIEkqVYQFFEYND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.98|      15|      23|    3576|    3598|      31
---------------------------------------------------------------------------
 3566- 3580 (26.44/ 6.95)	EMPHVIVIYIINPFN
 3589- 3603 (25.54/23.29)	EQPKFALISLMRAFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.53|      10|      17|    3853|    3862|      32
---------------------------------------------------------------------------
 3853- 3862 (18.56/11.91)	IKEACNLCAE
 3872- 3881 (17.98/11.26)	IVSACFVSME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.98|      13|      34|    1591|    1603|      33
---------------------------------------------------------------------------
 1591- 1603 (25.77/15.69)	NRYY.HTISDKFVG
 1627- 1640 (21.21/11.30)	NQYYtFTIDGRLEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.39|      20|      23|    1350|    1369|      34
---------------------------------------------------------------------------
 1350- 1369 (35.74/24.31)	KNDDGYKKD....KTCRLSKSFEM
 1371- 1394 (28.65/17.65)	KADQQSKRNlirhRYERMLRAFEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04327 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNNLGSWNQMPHSNFPSRNSYQQNYLPNQNNVFGGNSNYGRNIPTTLENDEEQTCIMKEN
2) INDLDSSYEDDSNDSNSDGSNDSTDYDNSPINAFDEEMEAEIEKELKETEFNSSPNDSSEELIDSDSESES
3) NTSGINLLNPLTPGNPMTPSMNPLTPQMANPMTPGTSTLDGSQNINALTPNPGSISSSGPPSNYMNPGSNNYPNPGSNSYSNPGSNSYPNPGSNSYPNPGSNSYSNPASNTCPNPGSNSSVLQSIISQPNSQGNPQHFLPGNISSPSSFHGSGQIGQTMMQSPIMNSENQFMPNSGNYNF
4) RQMNQSCYNPMRDNYNSGMFQNMNNQNVFMGNDKHNVSYNNDGTNALYDHNQYNSNINQMASGDSMSNMRPEMNSNMNQMINSHYNNPMQQFNNSNNLPDRNSQHYPLETMNHQTSGNINQGYINSGSHHMAGGNQRVNYNNQMPDSQYYNKLPNMNYENNSQNFINNRNSYGDENNPNEVPFDSTFNNSVGNQHHQISVNQGNEMFNAKNISFN
5) SPGNNYQMNYNQNNYMDSEGNVQMFNNDDHEGSSMDGMYDDLLHPHSSRDNQQTFDNSPMPL
1516
2045
2515
2696
2912
1575
2115
2694
2910
2973










Molecular Recognition Features






MoRF SequenceStartStop




NANANA