<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04325

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMDQNQGTISVSPFPFPPEYAHEYTTENIKSGRFRYPPPIPKKYKLFGIDYDRDNDKEPSLLDLKIPQLYNSKEDIKKELKKLNMSMIAAYLDLLDVLIHCPSDPERIQRIEQLRLLFINFHHLCNQLRPIQARDNLVAICEDQVIDIVRVAESLRQIVKLGKSDTYDLFKKYVKALKDKKDRYYKKKKSLIRGKKLEQKQQKMVGEINYPSTDINNIENIDEVGYLNNEVNTNETCDNDMIFSISSGVGNVNTSEHHGKESSLIFNRDEQLANIFNSLDIF
Length281
PositionMiddle
OrganismStrongyloides venezuelensis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.09
Grand average of hydropathy-0.643
Instability index37.83
Isoelectric point6.61
Molecular weight32705.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04325
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.76|      11|      19|      13|      28|       1
---------------------------------------------------------------------------
   13-   23 (23.97/19.00)	FPFPPEYAHEY
   33-   43 (23.79/ 7.72)	FRYPPPIPKKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.68|      15|      19|     204|     222|       2
---------------------------------------------------------------------------
  208-  222 (26.44/21.25)	NYPSTDINNIENIDE
  224-  238 (27.24/11.46)	GYLNNEVNTNETCDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.34|      15|      21|     240|     254|       4
---------------------------------------------------------------------------
  240-  254 (25.16/16.03)	MIFSISSGVGNVNTS
  263-  277 (25.18/16.05)	LIFNRDEQLANIFNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.90|      18|      21|      91|     108|       5
---------------------------------------------------------------------------
   91-  108 (32.94/23.08)	LDLLDVLIHCPSDPER.IQ
  113-  131 (28.97/19.51)	LRLLFINFHHLCNQLRpIQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04325 with Med7 domain of Kingdom Metazoa
Unable to open file!