<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04314

Description Uncharacterized protein
SequenceMTNTIKNYKISHWKAENYENRGMRKNSTNRSFDIFYQDPMQDEDNISSIERITSGYVSNSLPYEYDSYIFNQRNRMGDDFIDKTSKKAFLFFENLLNKHCVDNNKSCKKISLPRVFQVSEWNYKVPKNPNIYEFFENLANGKDFYSLIKKFPSFNLKENYLDYLYEYNVPILRAIWFIKIVAVFKATHIEDGKAPKKSQAQQIALEYVQCIISGYTIYTFKYLYTNGVCDERKVKKWNYFALLIKHMFEEGVLDRQDFLTDIIDLLNIYIDFGLDDPTKFKILFLFLSQFSSFITQNIIISRRLAFVICKRIRKYHLDYMNLIGQPITCPEVMVKLMKCEKHRPIISALISMFYSIMTECIQAITVKYITIDNKFSGINCYKDLTDTPLEYLTCRFDEMCKEANLLPLNMIEIIKNKIDEFQKRSIDIRYTLHNTISQNNNCSEISLMILKIFSILDNIYLANKKNMVEIYKSIFDLETGIDKEIEKLIKLRMIIHWCITSQRSGTYRVSIVVKLLSIHLSGVKNCVKEMIKILNDYLYTEGPCLKYSNFGYEFRSIILLLNDLQKYGLIKYKDLLDNWISLGKININECLWGRTSKYVYGENYERDLHPSWNKYIEMSSRYALLFYRRDSEKHFFINIENITMEERIFLQMPILPSIENKDIILYRNNIIYGISIVQKEHLNYLKEIARGIIKVWKKLYYFKIKINKGKSYFHEYHDIKYYKSCGDILKKFRKQTYYDQTLITYWVGNDFKSYIEGFINNTTNILPGSDGLDYIMRMFCISMNIGGMIEYVVDLLEKIGKLEDIMVIRGYNLISGMITKSYAFTVTGYLSEHTNYFLFHPNASDVLNGLFRTIENTIILENYPRTGYDTTIGMFIYYCKNVLIKEGIVNNNSILGSDKHFLKLYPNPFIEIKNDLPKIKVKKLFFGKYLKASPQGMVISEFKSIIKKMNKGGFSLRIAFILSALQIVKDLGRDINKISMLANYVSNISVQLKMENEWLRVILEICSLTTYPNTLYKNVHRIINVANTTSHYSISSFITILGGKYVFRPSELIENLIKTNLISVFKGNYLRSKYGYEKVILSALICTKLLTGYHDPFKLPRGYSGISEVKRPIVYRLADFKVCNVLFNHEYNNVIFKFIQLLSLANRPIRNTKTKKPSKKIRINHFFKACLLCLSEQPWFYQYMKFSILQDDVLKNKNYLFKNYKITGTLLNFISREKGDRQNKLQILAYAEKLSKKNFIEKNLESLNIWNFKAVLWSLYGMVNDVIKKPKKSNYAQKIYNCNEIMGDIARGIKNIFTTNSNSYGKNIIFKNNTFFRLKDISNLWLIEYLINEFPKINIPKCNSNFNRMSLVPLSRSVFIELSSIITESYPKNEYGKKTEQISHLFHLPPFSKLIQTLANLEPLCSHGLLQGVYSYLNNIVKEFNTKRILCPQLLKEKDGIILRVLLVCGMMDQLLTMPTVEPWAYLLWQLLYFEIIHKEREEKYYFICYEALSTILFISTYKIHQRHNEKLHYRGRYKAYSHFCKKVRRECQDRPFPIAKLELSQLLPLPKRTFDYIVFDYYHNSVGKIQNISKINGSKDDTTSLICQNGFYPIDKIKLTTFEIIPSFFHENLGRRSVNYSFYQAQLINYNPKLDRNIILKLLFHKHNKSFPKAPIYGDDKVLKNSLFYKPPEIEYNGKKEKQEQSPLDKLVDITSKSISKSPINISKKQTELNIVNKLEEKINISSTKDLQPTSKNVGNFSNSHNQNTNYVNELQSNRNFNSSQQVFNKKDSNIGQNSVKNPNVSIPQPTLTQHANQNHLISQGIKNNTYPYHTSNSFSTSELHKATKRSLSPSSNTLVKKRKDNSENIPISSMVKQQTNFNNIDTNNILPQPVTNIYTQSQNQQKIGVSQQSDIPPNPYQQTNHPRLPINQPTLISSNVENFVKQQHIPQQPKTLINPQIRGNGIEAGGMGQNLQQGRQNFKNGFENTNIMMKDVIQQRNNFNQNLQHQQQYNTTINNQHLNNGPMMNQYQVNLRKEMIYRNNQQQNEMQFHDPNMVRLYNQGNPQQQQPLNGNQMFRR
Length2062
PositionKinase
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.397
Instability index41.10
Isoelectric point9.42
Molecular weight241887.92
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04314
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     211.69|      38|      38|    1696|    1733|       1
---------------------------------------------------------------------------
 1565- 1582 (25.37/ 7.38)	..NSVGKI...Q.NISK.................................INGS......KD.D
 1583- 1638 (37.11/14.21)	TTSLICQNgfyPID.KIKLTT.FEIIPSfFHENlgrrsvnysfyqaqlINYNPK......LDRN
 1650- 1684 (47.38/20.18)	..KSFPKA...PIYGDDKVLK.NSLFYK.PPE................IEYNGK......KEKQ
 1696- 1733 (60.02/27.54)	TSKSISKS...PINISKKQTE.LNIVNK.LEEK...............INISST......KDLQ
 1735- 1775 (41.81/16.94)	TSKNVG.......NFSNSHNQnTNYVNE.LQSN...............RNFNSSqqvfnkKDSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     215.28|      41|      41|    1847|    1887|       2
---------------------------------------------------------------------------
 1799- 1847 (26.52/11.08)	..QNHL..ISQGIKNNTypyhTSN..............SFSTSELHkatkrslsPSSNTL..........VKKRKDN.....
 1848- 1887 (66.15/41.35)	.SENIP..ISSMVKQQT....NFN..............NIDTNNIL........PQPVTN..........IYTQSQN...QQ
 1893- 1928 (44.50/24.81)	QQSDIP..PNPY..QQT....NHP..............RLPIN............QP.TL..........ISSNVENfvkQ.
 1929- 1963 (35.22/17.72)	..QHIPqqPKTLINPQI....RGN..............GIEAGG.M........GQ...N..........LQQGRQN.....
 1970- 2030 (42.90/23.58)	NT.NIM..MKDVIQQRN....NFNqnlqhqqqynttinNQHLNN...........GPMMNqyqvnlrkemIYRNNQQ...QN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.58|      23|      49|    1120|    1153|       3
---------------------------------------------------------------------------
 1106- 1137 (33.24/34.85)	ISEVKRPI...........vyrladFKVC.....................NVLFNHEYnnvIFK
 1142- 1202 (20.33/11.02)	LSLANRPIrntktkkpskkirinhfFKACllclseqpwfyqymkfsilqdDVLKNKNY...LFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.11|      36|      41|      91|     126|       4
---------------------------------------------------------------------------
   91-  126 (67.16/33.84)	FFENLLN.KHCVDNNKSCKKISLPRVFQVSEWNYKVP
  134-  170 (60.95/30.06)	FFENLANgKDFYSLIKKFPSFNLKENYLDYLYEYNVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.74|      25|      38|     666|     701|       5
---------------------------------------------------------------------------
  677-  701 (42.19/32.68)	VQKEH.LNYLKEIARGIIKVWKKLYY
  713-  738 (40.55/13.69)	FHEYHdIKYYKSCGDILKKFRKQTYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.16|      24|      38|    1329|    1356|       6
---------------------------------------------------------------------------
 1329- 1356 (35.71/25.50)	YLINEFPKiNIPKCNSNFNrmsLVPLSR
 1370- 1393 (42.45/19.56)	YPKNEYGK.KTEQISHLFH...LPPFSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.65|      30|      48|     505|     551|       7
---------------------------------------------------------------------------
  524-  554 (53.65/48.14)	KNCVKEMI...KI.LND........YLYTEG......PCL.KYSNFGyEF
  573-  622 (25.00/ 6.60)	KDLLDNWIslgKInINEclwgrtskYVYGENyerdlhPSWnKYIEMSsRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     341.24|     113|     141|     830|     956|       8
---------------------------------------------------------------------------
  830-  956 (167.02/113.81)	LSEHTNYFlfhPNASDVL...NGLFRTIENTIILENYPRTGYDTTIGmfIYYCKNVLIKEGIVNNNSILGSdKHFLKlyPNPFIEiknDLPKIKVKKLFFGKYLKaSPQG...MVISEFksIIKKMNKG...GFSL
  978- 1099 (174.22/85.65)	ISMLANYV...SNISVQLkmeNEWLRVILEICSLTTYPNTLYKNVHR..IINVANTTSHYSISSFITILGG.KYVFR..PSELIE...NLIKTNLISVFKGNYLR.SKYGyekVILSAL..ICTKLLTGyhdPFKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.78|      37|      38|    1448|    1485|       9
---------------------------------------------------------------------------
 1171- 1190 (25.64/13.04)	........LLCLSE.QPWFY...Q.....YMKFSILQ.......
 1448- 1485 (66.66/53.67)	VC.GMMDQLLTMPTvEPWAYLLWQ.....LLYFEIIHKEREEKY
 1488- 1521 (39.47/25.01)	ICyEALSTILFIST.....YKIHQrhnekLHY.....RGRYKAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.66|      42|      43|     397|     438|      10
---------------------------------------------------------------------------
  397-  438 (74.65/54.92)	DEMCKEANLLPL...............NMIEIIKN......KIDEFQKRSIDIRYTLHNTI.SQ
  439-  502 (54.01/37.14)	NNNCSEISLMILkifsildniylankkNMVEIYKSifdletGIDKEIEKLIKLRMIIHWCItSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04314 with Med12 domain of Kingdom Metazoa
Unable to open file!