<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04305

Description Uncharacterized protein
SequenceMSDLKKVDECMPPPKMIPSSSILPSDDSKFIKPIGIPNKSKKYVYVEPRREWNVMEYSLEGAEALMPPKTFQESLAEKASRIDWKKIVGSNVTYDNPDETFDTESDKALDLVDRILNLNIHQKSYKPPQHYLNNTSKLVVKSGDLQINKNNTLNNENKERERFSKLLKEANEVGLKFPNDNVDYEELSKHVDINTLNNSEGPVVVTDMEQVIENNIAYENYKNQKYIEGDTTSDKKRRNKEKESDDEDIGYMMGKAAVESFKEGRIKQELEHHGILQTRKIINDPQISSKIRYFVQKRLQKKILEYNFIGMPLQNDESKTIFQILKPSSNNTFGILPQDVSTEAFDPTKCDDFVKELTDRQVDAAKKAWDALELQTNEFDIFSQLRNDTLEAKNRGEDIKTISINFGSSRIVIPIIVRDSFSTEPRKSDEMSSDSEDDDEDFQMEIDKGPEEENHVEPTSSVAFYINRTGKLLGCKIDGESYSLDKPEFLGNELTMKMLEAIENSEDNKKEGETHSDDESTSSRGRSKHKEADISSRPPSPIVPEAGPWHKVAKYLHESLQQINYLHDQLRVMDTSYMKPLTVAESIGDEHTAINSKLYLWVAKRKALEESVAVLETGTKHRKVDTESFEDKQAFFNELKSMREFWRLRKVGRFLTGDLGYRTFGSKFVPSESFDVTRKSSAMLEEERKHKAEICDTSPLSYLQVIVPCDLMRRTVMSVDIVIDHNTGMELPSSRRRNNSDLDYMVVKPEDAMKIHWRKALLWAQESLICRDIFKNLFTDAAQATDIFSMQRENVLMVSLFSNVVLKIQLDFYPFKDGDLPQPGIPVLNTLLRHLFLSDLCIRPKLLQQFVTLPLIDSQDYIAGRTFSDASKSEMKEMINFTRHTTLLSRLCKVASHYKLVQEIINELEAFSIKHPDPSISWKFYRITSIESFINVVLSNRGFVDIIPKQLFTISITHNNILINIRAKEGKDLFECGHNLEMFVKSLKMVYCRYMINSVAIQSKQWVWYVLSSNLRFSESHYSNACDLTLYMSNVSGLYHIYFFVNYITLEKNITVERNIDLEWQKDETLTIEGNKNGEKYVHLDYNSLIGDSLLRKFDFLFAILR
Length1106
PositionHead
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.09
Grand average of hydropathy-0.550
Instability index49.23
Isoelectric point5.63
Molecular weight127683.49
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04305
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.98|      37|      40|     881|     917|       2
---------------------------------------------------------------------------
  881-  917 (63.63/44.51)	FTRHTTLLSRLCKVASHYKLVQEIINELEAFSIKHPD
  924-  960 (63.34/44.27)	FYRITSIESFINVVLSNRGFVDIIPKQLFTISITHNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.03|      16|      40|     696|     712|       3
---------------------------------------------------------------------------
  696-  712 (26.02/23.70)	DTSPLSYLqVIVPCDLM
  738-  753 (30.01/21.51)	NNSDLDYM.VVKPEDAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.62|      15|      59|     447|     461|       4
---------------------------------------------------------------------------
  447-  461 (28.52/21.28)	DKGPEEENHV..EPTSS
  507-  523 (22.10/14.50)	DNKKEGETHSddESTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.38|      31|      61|     132|     163|       5
---------------------------------------------------------------------------
  132-  163 (46.78/38.26)	LNNTSKLVVKSGDLQINKNNtLNNENKERERF
  196-  226 (53.60/38.89)	LNNSEGPVVVTDMEQVIENN.IAYENYKNQKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.54|      66|      68|     554|     621|       6
---------------------------------------------------------------------------
  540-  610 (99.01/99.98)	SPIVPEAGPWHkvaKYLHESLQQINYLHDQLRVMdTSYMKPLTVAESI.GD.EHTAINSKlYLWVAKRKALEE
  611-  679 (98.53/87.32)	SVAVLETGTKH..rKVDTESFEDKQAFFNELKSM.REFWRLRKVGRFLtGDlGYRTFGSK.FVPSESFDVTRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.27|      19|     192|     230|     248|       7
---------------------------------------------------------------------------
  230-  248 (33.42/21.55)	DTTSDKKRRNKE....KESDDED
  419-  441 (28.85/17.44)	DSFSTEPRKSDEmssdSEDDDED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.73|      37|      47|     964|    1002|      11
---------------------------------------------------------------------------
  964- 1002 (59.87/51.86)	NIRAKEGKDLFECGHNLEMF.VKSLKMVYcrYMINSVAIQ
 1014- 1051 (61.86/45.12)	NLRFSESHYSNACDLTLYMSnVSGLYHIY..FFVNYITLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.01|      24|      38|     794|     817|      15
---------------------------------------------------------------------------
  794-  817 (42.25/31.82)	NVLMVSLF.SNVVLKIQL..DF..YPFKD
  829-  857 (29.75/19.93)	NTLLRHLFlSDLCIRPKLlqQFvtLPLID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04305 with Med17 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TEPRKSDEMSSDSEDDDEDFQMEIDKGPEEENHVEPTSS
2) TMKMLEAIENSEDNKKEGETHSDDESTSSRGRSKHKEADISSRPPSPIVPEAGP
423
495
461
548










Molecular Recognition Features






MoRF SequenceStartStop




1) SKFIKPIGI
28
36