<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04302

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSENSNSDDNGYDSKKDESFEITIPEFPFEPDDAYSYYENDNIRVKTKLEKGEKLPNLPPVPEQHAPGTIPLAILLQYVCQKINQELFSMTEVVCKTTDVGKKVSLVQFVYITKNLLSKVLAIVKWFRYFKRYRLCIPIQNFLDQQLQQYRDTADALCGIARGELTYARMPQYNIDSAIDVICGVYARLPLSIKKRFIPEPEISTQELANILTRINLAIKTRLSFVAHYLPTRIKNIITINGTVTFVVPGEFEITLTLPGETIDVKWKLLRVKILINDYEMGEGKELVHHLQLKKLHKFCQKILNKSRRPLIGVYNFLHDFCITLQFDLIFGEILNLTQGAYKNKVFISFCNVQKRYISIEYWRRGKAKKGSPTPTYQIVFSIPKKAKNGGIVVEYRPSTSFPVNFYKEFEGKPSVHDILKSAIEYNVYKKLILLKEELEKCRPKLVVKLTGDLLPKVTVNLLNINIQEEGCELSFGVNFFTGAYMCVGDELKESLLLKTIVIGLNNNIDVKKLEKCFDGIRTEFIMKKYVQSVNMLNVRLVVEKTLPSIFRKYSYFENSIKLYFQIIKEPQYYITVTFTDPKKKGLYINFFFLSTIEGKSTIIKLNPLDFYTPPKVNFQRRACLSEIGNTSNYGQKESLLQYTPHQIGAIINGIESKINMIAVCDEFLKKNVILSSVKNDCINNSPYIEIPNISKLIGSDNSKFFENMKDIILRNDSRFKHIWPLEYSLINTPIVEDFYKRDINGQGLVHLTGKKKCFHDVRSSGMLVPNVSFYEIITLALVDKMKAFSMLHKHVYQFAYAYYHYYNQYCRIKLYSYHKLIIAYGENKDQLVFLTYKANKDSFLLSFGQDLGQNFVNGDLNDWEYQNSSILWNPHNLVASFLAEKSGRKSFLLELVDYLINTTKPLTSLYNGIRHKIISSSALTQILIGESIYSEEFDIQLIPHSEYNFKVVCGRMTLEVFMYAKDYVYIKDSSYEKPKLYGLKEFLKSFGGSVIDIDTIETDEVSLEKGARSLPESKCSEIEEILRNSSSVPCYTNIDDDKNNKDMSIKDITGSDGKYREEYFSSSRDLIKISHDSFDKLLYQDSTNKPISDFRNYLYTLRSFERLTTILVHNYGKPMLGGGGLTIHYANVTHHMVKVTFSGAKKPDGTIPCNINFIIFIQPKTFKIKLKLEYIGDIQPTADEISIVEEYFEEVMKYTESPQSIYSFMNLIRMTAPKFFSCITNLMLLQRTPDPSNFYTMNFEFVSIIQRKDELIPKFVPQILINELSGRILIPITIRPQKSDYNNKANDTNNKIKLDFVWEAANNEIYIHNANDEFFKMINQKIIQFNNTVKESLECTLEACIRYILKNEIKST
Length1357
PositionTail
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.229
Instability index37.57
Isoelectric point8.68
Molecular weight156912.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04302
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     394.90|     119|     125|     206|     330|       1
---------------------------------------------------------------------------
  124-  182 (58.90/29.24)	.................................................................VKWfryfKRYRLCIPIQNF.LDQ........QLQ................QYRDTADA........LCGIARGEL..TYARMPQYNIDSAIDVI
  209-  330 (187.80/130.97)	ANILTRINLAIKTRLsFVAhYLPTRiKNIITIN....GTVTFVVP.GEFEITLTLPGET....IDVKW....KLLRVKILINDYEMGEGKELVHHLQLK................KLHKFCQK........ILNKSRRPLIGVYNFLHDFCITLQFDLI
  332-  476 (148.20/85.93)	GEILNLTQGAYKNKV.FIS.FCNVQ.KRYISIEywrrGKAKKGSPtPTYQIVFSIPKKAknggIVVEY....R.PSTSFPVNFYKEFEGKPSVHDI.LKsaieynvykklillkeELEKCRPKlvvkltgdLLPKVTVNLLNI.NIQEEGC.ELSF...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.42|      37|     125|    1170|    1214|       2
---------------------------------------------------------------------------
 1170- 1214 (52.43/46.09)	KLKLEYIgdIQPTADEISI...VEEYFEEVmkytesPQSIYSFMNLIR
 1296- 1335 (59.99/33.20)	KIKLDFV..WEAANNEIYIhnaNDEFFKMI......NQKIIQFNNTVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.47|      59|     125|     934|    1006|       3
---------------------------------------------------------------------------
  934- 1006 (87.76/90.38)	YSEEF.....DIQLIPHSEYNfKVVCGRMTLEVFMYAKDYVY..........IKDSSYEKPKLyglkeflksfGGSVIdidTIETDEV
 1060- 1133 (93.71/61.47)	YREEYfsssrDLIKISHDSFD.KLLYQDSTNKPISDFRNYLYtlrsferlttILVHNYGKPML..........GGGGL...TIHYANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.63|      10|     125|     608|     620|       4
---------------------------------------------------------------------------
  608-  620 (15.85/14.50)	PLDFYTppkVNFQ
 1236- 1245 (21.77/ 9.81)	PSNFYT...MNFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.16|      43|     125|     684|     750|       6
---------------------------------------------------------------------------
  684-  728 (70.44/73.96)	NNSPYIEIPNISKLIgsDNSKFFENMKDIILRNDSRF....KHIWPLEY
  755-  801 (67.72/29.71)	KKKCFHDVRSSGMLV..PNVSFYEIITLALVDKMKAFsmlhKHVYQFAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04302 with Med14 domain of Kingdom Metazoa
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