<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04300

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQKCTSKDEYMRTIAKVINAINCNSKSSSMPSVLSNHYNKNDPQPTQQNDIPLQAVGGNNISSSTDISMRQLNQVSSSGIPIHRQSPLPSNNNITSHTPPVNSILQQQQQQPSSGSGFGSSQKIASSTGYSPQLSQSTNQTQFMRLSQQTKAEYNGINDQVNYGIPPINSMYPQTMNKPSIPTEDMMSGNPMIQRQRAWNVQQDNGQYMQNSMIQMPQPNMGMGQPMMQYINQQPPYTDYNYQNSGIPINNSMNFNNNCLPIQNDKLYESKLKELRQHASMIKGKSNYYRSSGNPTAAGRLDFIYDVLTGERKPTYETILKIEDEINKILLSQNIMVNNIGMSSQVGGPIMQEPKLLQQPYYSQPQWMGPQQLQPINSGPSPYTVTAANPLPHQQYNVPNSPSGSQQQQSLRHSPYQIPNKHAQGNYTTRQSSLPHGKSQSQPTNINTYQNNFHYPTQSLTTPTPITNNSNTIDEIYSTSYDQMVGGKGGDDLNGLYGQQQSQSNTPNFTTYLTSNMSQEISTLNSQFTFKNICGTYDGNYINVDVIFNNFEKDFPPFRLVIPKTYPAVPVSFEQLPLDIESFLYEEVQSHMYSEIRKKNPKTITDILKIAESAALDFYSKQQCNQMNTPVLDDLFRSSQYDSALQ
Length695
PositionTail
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.841
Instability index63.08
Isoelectric point6.20
Molecular weight78468.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04300
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     205.84|      32|      32|     420|     451|       2
---------------------------------------------------------------------------
  119-  148 (41.83/13.57)	RQL........NQVSSSGIP..IHRQSPLPSNN..NITSHT..P
  197-  231 (35.29/10.25)	QQTkaeynginDQVNYGIPP.....INSMYPQT..MNKPSI..P
  245-  269 (33.21/ 9.20)	QRA........WNVQQDNGQYMQNSMIQMPQ.......PN....
  420-  451 (61.58/23.59)	QQL........QPINSGPSPYTVTAANPLPHQQ..YNVPNS..P
  455-  484 (33.92/ 9.56)	QQQ........QSLRH..SPYQI....PNKHAQgnYTTRQSslP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.72|      22|     122|     270|     291|       3
---------------------------------------------------------------------------
  270-  291 (47.82/24.15)	MGM....GQPMMQ..YINQQPPYTDYNY
  389-  416 (35.90/16.25)	IGMssqvGGPIMQepKLLQQPYYSQPQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.73|      18|      24|     590|     607|       4
---------------------------------------------------------------------------
  590-  607 (34.20/21.01)	YINVDVIFNNFEKDFPPF
  615-  632 (32.52/19.64)	YPAVPVSFEQLPLDIESF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.88|      12|      32|      67|      78|       8
---------------------------------------------------------------------------
   67-   78 (21.39/12.97)	INAINCNSKSSS
  102-  113 (20.49/12.10)	LQAVGGNNISSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04300 with Med15 domain of Kingdom Metazoa
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