<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04298

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMDSTFRHVSGSDYVDSERKRFEAECEFVQALGNPHYCNFLAQKGYFKEEYFINYLKYLQYFKQPEYAKTIVYPHCLFMLDCLQHKEFREAIGNVNNAKYIENQQMLQWQYYYRKRNEYNARIVQAKEAGELKTTDDVINLLKELANPEKVKESGDEKNVEKSLSEVDQNLVGEEGTVTQKEIMRLLKEVREGMKISDDGNVLIDEESEDDDGNEELTSEIKELLEEIERESNDNLQKAFSEEEDVEIEEYDQDLKQAPYTQNEDYEDYTREQEVKRIEAAFDQVAEYGELTEEELTKNGYPIDVLYDSNIISLAIRSKDCCTSDQKSRKYY
Length331
PositionMiddle
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.955
Instability index51.88
Isoelectric point4.49
Molecular weight39030.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04298
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.71|      13|      51|      59|      71|       1
---------------------------------------------------------------------------
   59-   71 (23.27/11.93)	QYF..KQPEYAKTIV
  109-  123 (18.44/ 8.21)	QYYyrKRNEYNARIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.30|      19|      19|     251|     269|       2
---------------------------------------------------------------------------
  251-  269 (34.03/15.93)	DQDLKQ..APYTQNEDYEDYT
  271-  291 (24.27/ 9.69)	EQEVKRieAAFDQVAEYGELT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.99|      37|      42|     165|     205|       3
---------------------------------------------------------------------------
  127-  160 (38.69/17.25)	........EAGELkTTDDVINLLKELANPEK......VKESGDEKNVE
  165-  205 (51.11/36.55)	EvDQNlvgEEGTV.TQKEIMRLLKEVREGMK......ISDDGNVLIDE
  210-  249 (46.19/23.03)	D.DGN...EELTS....EIKELLEEIERESNdnlqkaFSEEEDVEIEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.24|      14|      38|      34|      48|       4
---------------------------------------------------------------------------
   34-   48 (24.85/26.03)	PHyCNFL...AQKGYFKE
   73-   89 (24.39/18.18)	PH.CLFMldcLQHKEFRE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04298 with Med31 domain of Kingdom Metazoa
Unable to open file!