<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04293

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNYDGGNDMVPFGVLLKYSCHKISHELTIISELLPKYKDYNRKITITEFSYMARGLISKILAIVKWLKNYNEHYMCKEIQKFLETQEQFFRETADVLCNIARGELVVARVPMYEIDAAIHLSYGENIKLPFAIKKRFVSDKCITNIERNKVLSMINKNILNRLSLISSILPPKIESIIIKNGMVTLTVPGEFEVSLTLFNNDLSMKWTLLNIKILVEQYDIGYGTKLVHPMQLFSIHQFLQQKIVVSKNPILDLYNCLHDFCTSLQLDVLYCETSQLIGSQYRNKLIVEKYDQDAGILIISFWLLKKKQYVPSQYKIKIFKDPSKLNDGLRVIQYPLRKNMPTLDLNTGRLSICRLINETVLIYAKEKLFSLKKKLANLKPHTYIEVTGNKYPKIDFWLFEKSEHPEEECLSIHVNLFTGEFIINLPYFESKNMLYEFADMLNNGASKKELETSLRNIRMEFLVHRIKKVYSEIKLPLVSTDIVLKNIDTSPGDRKIFGRINKSDCFIGIQLVANKITDEIVFIFFIYEKRKEKMRKFFSSDDSASNNMKLDIINNPWYKIFHKKHNIEVSLEKCEKCITSNKLWAGNYRNLRDSCYVILHEWQLTEISRVYSNGLTKKNDVKLDVNNVPFLVLNSSRNISESESKNVLSYGNCFMRLDDRWPSQKWGAFTIELFIRNVALKVDFYKNCSVRESLAYKYGVKGTNIGIPCNIYWLYPNNFTQKIAEILALESCKIMNFHRLLEDIAPHYYKFFNKYCSIKYLSNCKVVFAYGQNRRYLLYLNYFGSKVDSYKFYFGQDASIGFVNDIPSTINNDPWNMKFNAHNNVHEHLLKWKLDRTHLHHLLLYLIKTCTPINILYNIYIPSVYSGVFVSEMVSRNYQMKKLSPGRLIAIDEYHIRLLFADIVIEFWIGNENNILIGDVSKECAKIPGLHSVIHTYSNKIKLYNKPFFEMTRNECNEFFEIKNKRFQVNSNTLDKLCLKIESGNKYGILIEYLHSQHILNHIKMLTKVYSLEKAECPSILKFFNICLTNGSISFNVQYLLLDLETREYNNISTIIYIDTNYFTLRILLNIDTGFQQPESFIKSCQTYFEKIIYYNYNNLSFFGFFKLLLTPSQDVLNVIENIFRFESENTILHNNTTISIQWVRESFTSENNSYILRSFVESNFEESYVVIPIKISNIIVKEQCVPLDIYVFHLKYYYNTGLMEVTDEEEVYPNLNSYLLTYSKEARTSSVNPFLLCLEKIITDYIPVLKS
Length1253
PositionTail
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.13
Grand average of hydropathy-0.151
Instability index41.70
Isoelectric point8.78
Molecular weight146956.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04293
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.74|      12|      65|     713|     724|       1
---------------------------------------------------------------------------
  713-  724 (25.86/13.33)	YWLYPNNFTQKI
  777-  788 (22.88/10.94)	YLLYLNYFGSKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.53|      35|     272|     730|     769|       6
---------------------------------------------------------------------------
  730-  769 (58.65/44.37)	LESCKIMNFHRLLEDI.......APHYYKFFNkYCsikyLSNCKVVF
  995- 1036 (58.88/31.87)	LHSQHILNHIKMLTKVyslekaeCPSILKFFN.IC....LTNGSISF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.70|      37|      71|     213|     250|       7
---------------------------------------------------------------------------
  213-  250 (62.20/46.31)	KILVEQYDIGYGTkLVHPMQLFSIHQFL..QQKIVVSKNP
  285-  323 (60.50/40.21)	KLIVEKYDQDAGI.LIISFWLLKKKQYVpsQYKIKIFKDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.57|      52|     285|     340|     398|       8
---------------------------------------------------------------------------
  340-  397 (72.52/77.61)	NMPTL....DLNTGRLsicrLINETVLiYAKEKLFSLKKKLANLKPHTYIEvTGNKYPKIDF
  407-  462 (83.04/57.67)	EEECLsihvNLFTGEF....IINLPYF.ESKNMLYEFADMLNNGASKKELE.TSLRNIRMEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.29|      38|      71|     537|     574|       9
---------------------------------------------------------------------------
  537-  574 (66.56/39.14)	KFFSSDDSASNNMKLDIINNPWYKIFHKKHNIEVSLEK
  610-  646 (59.48/34.17)	RVYSNGLTKKNDVKLDVNNVP.FLVLNSSRNISESESK
  811-  832 (31.24/14.35)	................INNDPWNMKFNAHNNVHEHLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.38|      28|     285|     673|     701|      10
---------------------------------------------------------------------------
  673-  701 (46.07/31.23)	ELF.IRNVALKVD...FYKNCSVRESlAYKYGV
  959-  990 (41.31/23.30)	EFFeIKNKRFQVNsntLDKLCLKIES.GNKYGI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04293 with Med14 domain of Kingdom Metazoa
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