<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04291

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDGSNFSDDSSSDEKEEFVNNSSDKLTGDIKKNWSLGKDFTKNKNNDDEEFEEILSYLPPVPQSHNSGMISLDLLLKLASHKVSQELIVLSELIPKAYDQSKKISLVEFSFVAMNLFSKILALVKWYRYFKKYRLCTPIQYFLDQQSQIFRDTADALCGIARVELSGARLPYFEMQSALNNIWGYFEILPLAIKKRFVPEPPVSKIDQKIVLSKINQIIKNRLSLISSKIPVGITDLIIKNGTVILKVNGEYEITLTLLSADVNEKWTLLHITILVEQHDIGYGTKLVHPLQLHNIHQHLQKLMNDSKNPINTMHNFMHEFCLSIQLDVIYCEAIQLIQKQYNRKLIIEKYDIEDGKLVISYWPKYNDKKISPSQYKLIITHSKSISFHGLRVYHSPYRNNMPQLDTNTGRLSLNTLISSTTTIRAREKLEVLKKKLDKVNPTSGTYISGCSLETIKFPLLNNCNLIEEDHLSFGVNRFTGKYFCFCNISESDENILNLNNILNNNGNIKELQRIINNIRINLLMEKYKKIMGLNYLIVNEAVLPKKAKEFLKDKEKNKICIKFHRDLPYYSIFLFSNNCNNSVSISQYIIFKNNCNEVIILPFNEKYQDSSKNEIDDSKKFKFLRNISSEISNVIHLPNEIKNLILVMDMSVRHLKLVEDFKKKGVSLDPINLMKPNDCIKLKINSIPTLHTKDLELLKYIEKLTVFCDNRANLLWPFEFYIQNIPIIADFYNHTLVEDISIKNYGKRNFILANRTSSSTACTSASLDIISTNFIEKMAICSMLYKQVLHFSKYYYEYYRKFCNIKIFNFQKLIVAYGKNRDQLMFLTYKPSRKTYLMSFGLGSSKSFVTGNKENYESHNGNFINVHNLILPYIHEMTRKEFFLKDVIHYLINTSDGLTCLYKSIKPRLISTEAFGQVSREMVFYNQQFQLELFVIDEHSFQLANGTISLGIYVFNTKYVYLKDSSYGEPAIIGLENFLKFYVENLISKSLFNMTQIEKNNYFVTSRKIFRIPLEIFEKITSINNTFKNYSILGKYIYNLRSFDKLRIIFSQPKEKTISKGCNIRFNDFQRTSYYIKVSFQGATMINGSIPCKIHFTVYIEPNTFDIKAKIEYEGTFKPSDSDIQIAQEYFEKMLSNGNCPQGVYSFINILRLTYPMSFNNLALLMQLEMRPKINHYYKLSLDLVSNDHRNADQTVQYSPSFLIDEKSFRVLIPVSLRPQIRESKKSKSVDPDRLKLNVVWDIKNNKLTLHKPSTDLMKYMNDKIVKHNEMIKDTSECVIESCLRILLIDHLKEPETLT
Length1301
PositionTail
OrganismStrongyloides stercoralis (Threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.262
Instability index36.28
Isoelectric point9.04
Molecular weight151435.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04291
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     299.99|     104|     113|     934|    1046|       1
---------------------------------------------------------------------------
  944- 1052 (166.84/117.51)	QLANGTISLGIYV.FN....TKYvYLKDSSYGEPAIIG.LENFLKFYVenLISKSLFNM.TQIEKNNYFVTSRKIFRIPLEIFEKITSINNTFKN.YS...ILgKYIYNLrSFD........KL...............................RII....F
 1054- 1211 (133.15/86.54)	QPKEKTISKGCNIrFNdfqrTSY.YIKVSFQGATMINGsIPCKIHFTV..YIEPNTFDIkAKIEYEGTFKPSDSDIQIAQEYFEKMLSNGNCPQGvYSfinIL.RLTYPM.SFNnlallmqlEMrpkinhyyklsldlvsndhrnadqtvqyspsFLIdeksF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.66|      67|      71|     641|     710|       2
---------------------------------------------------------------------------
  641-  708 (105.49/65.71)	NEiKNLILVMDMSVRHLKLVEDFKKKGVSLD.PI.NLMKPNDCIKLKINSIPTLHTKDLELL..KYIEKLTV
  712-  782 (94.54/58.34)	NR.ANLLWPFEFYIQNIPIIADFYNHTLVEDiSIkNYGKRNFILANRTSSSTACTSASLDIIstNFIEKMAI
 1227- 1264 (43.63/21.35)	........................KKSKSVD.P..DRLKLNVVWDIKNNKL.TLHKPSTDLM..KYMN....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.28|      16|      18|     279|     296|       5
---------------------------------------------------------------------------
  263-  278 (24.41/ 8.02)	DVNEKWTLLHITILVE
  281-  296 (28.87/18.65)	DIGYGTKLVHPLQLHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.26|      16|      17|     207|     222|       6
---------------------------------------------------------------------------
  207-  222 (26.41/18.48)	IDQKIVLSKINQIIKN
  227-  242 (26.85/18.93)	ISSKIPVGITDLIIKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      12|      16|     789|     800|       8
---------------------------------------------------------------------------
  789-  800 (22.62/15.66)	QVLHFSKYYYEY
  808-  819 (20.23/13.03)	KIFNFQKLIVAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04291 with Med14 domain of Kingdom Metazoa
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