<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04266

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSTSYLQQGKLLMSVDQLPVSGHVRKKIVPVSSRFSPAVDFRVLRTSSTSRREPLHMPPDYQKLIRHLKKRAPRNMDSLFSAQFPSSIASVATSHMTSVTVTSFPNASNYKPTFGPVSGMTPNPHVQIPTMQPPQSHHIQQFPASQACPIRTPPMMGGRIGTPIVGGPGPMGPPYAPTSSPYGTMMAPPNSVQQLNNFVHASMFNSSNGQMNPHHLGAMSMGQPLGQQMYAGAPGQMSMISPCSTNGYGAPSMIGGYGPSAPNIIGPSHASAPPAYPGAHVPPPYVSMNPIQSVQQPHMRQMQMIQQDTILDLHFDSVFDACPICSCNTSIRARELGLYITPPDVLRMPAHLQQAQIGSWSGFALEQANVCTCGFRFDSTSSTDVNMLDLLRIMCQQHNMGRMVHQIAHFVEQADKAIKAQEVSFDASSNSEYVLSQVDATELMLIGNSAAEMARISGNRSRNTNQPILQFFHPWGLQVANEVRDPREAEWRGLLCDIGPILERALRIVRCMHGVPGNIVEGPLSWRALTNKSQPKACTPIHDDDISSPEPIPYINVAAEKDAIRAAPHVVRHWEHLSLGPIDQPKDVLYLAVVPDSAEICGMAVKYMEQLSQMYERMRFGRHIAWPTGVDGRDGCVRVGCRTQSGKYPTETTTLDFLNLVGRYVDNKVFMTKLRLFTQQMEENVLHLVTERDDLFERAAFRETLALDWRAKRASAAAVALAVEQRLAESAAEQGGSVVPPEPPPTEPPLEPEDVPVDDPGTLPHVVVIYVVCYFYLVYLFSLYISVITSSFQFNPFTWGTEFRSGLFTRVATLAVMRAFNTVCLRLPSYRRSQLQLEIVPMEQVTDLLGCLPDYTNENGTSQGLLENSGKATVLSVYSQPRVLTADCIRSVQARCMTRFGPGSSLLDSLDEWERSGTNVFYKVPSNPYHLAPPPLLYQKYENGRVLQSSDEQVLYVTYCVAGSDWLCVTVTDSLGRLNDNCLINLRTRHDHHIYKYRQQTQILDAMGRLWTYILGILSMETRNWRLVIGRLGRIGHGEFRAWTYLLNKTALKRHSARLKEVCTACAQMPGCTGTPSILSACLVSTEPEPYLRVFPGFTFMDAYRPSRLSFLQKDSRKLNYDGMNFLSKKARSAAPDDTSITHIMVFPTSADIQLGSTDQHAVGEDDWDFSDMDIPQDGNDLGDDFLSSICMDNLGPPQQGSNFRAAGNSFFSENTAGLILDILHCTLQINPFFFHFYMVIADVSMENQPLATGFYVSTAPAADVPDWFWASCPSAKNRTPVHLKSSLHINVPLVHQGDEFLQGKAAAGEKQEKESAHPLDSTRTDEVHVLETYNALSWLNIDVVSGERRSCLPVHMQALNRLYHSVARLIM
Length1372
PositionMiddle
OrganismAngiostrongylus cantonensis (Rat lungworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Metastrongyloidea> Angiostrongylidae> Angiostrongylus.
Aromaticity0.08
Grand average of hydropathy-0.228
Instability index49.73
Isoelectric point6.43
Molecular weight152280.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04266
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.59|      51|      69|     166|     228|       1
---------------------------------------------------------------------------
  132-  185 (96.79/53.20)	QPPQSHHIQQFPAS..QACPIRTPPM.MGGRIGTP.ivGGPGPMGpPYAPTSS.PYG..TM
  194-  253 (72.81/33.24)	QLNNFVHASMFNSSngQMNPHHLGAMsMGQPLGQQmyaGAPGQMS.MISPCSTnGYGapSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.17|      10|      57|     278|     296|       3
---------------------------------------------------------------------------
  265-  274 (19.36/ 9.23)	IGPSHASAPP
  281-  290 (20.81/14.15)	VPPPYVSMNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.36|      80|     241|     320|     402|       4
---------------------------------------------------------------------------
  320-  402 (136.59/112.76)	DAcpICSCNTSIRARE...LGLYITPPDVLRMPAHLQQAQIGSWSGFALEQANVCTCGFRFDS..TSSTDVNMLD.LLRIMCQQHNmGR
  562-  647 (132.77/96.03)	DA..IRAAPHVVRHWEhlsLGPIDQPKDVLYLAVVPDSAEICGMAVKYMEQLSQMYERMRFGRhiAWPTGVDGRDgCVRVGCRTQS.GK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.13|      24|     184|     727|     752|      10
---------------------------------------------------------------------------
  727-  752 (42.32/28.93)	LAESAAE...QGGSV...VPPEPPPTEPPleP
  906-  935 (35.81/18.22)	LLDSLDEwerSGTNVfykVPSNPYHLAPP..P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04266 with Med13 domain of Kingdom Metazoa
Unable to open file!