<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04251

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMDSIGSGVASSGSLRTKISLKGRYSQLSLVCPFHLMKPELPQQSVLLGSNDLLAEYDMGSSYQRFCGSKRLREDLGSFLPHLVGSFNFENALEFSSLRMLVEKPPITGKEITSLSAGAMAGFRLTPGAVPEPYRYFDNKVDDLSSDTMNYDENGEETKHKRKYKWSLDDLDDADLDRKYRKHRSEDKDRKKEKKKKKDKKRKRDSKEEDQNNKVRKV
Length217
PositionHead
OrganismBrugia malayi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.08
Grand average of hydropathy-0.997
Instability index40.28
Isoelectric point9.29
Molecular weight24865.86
Publications
PubMed=17885136

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.46|      15|      15|     178|     192|       1
---------------------------------------------------------------------------
  162-  176 (23.32/10.70)	KYKWSLDDLDDADLD
  178-  192 (24.09/11.26)	KYRKHRSEDKDRKKE
  194-  208 (22.05/ 9.76)	KKKKDKKRKRDSKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.94|      15|      16|      57|      71|       2
---------------------------------------------------------------------------
   50-   68 (24.36/14.53)	NDLlaeyDMGSSYQRFCGS
   69-   85 (22.58/13.03)	KRL..reDLGSFLPHLVGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.07|      19|      26|     101|     119|       3
---------------------------------------------------------------------------
  101-  119 (31.56/21.89)	VEKP.PITGKEITSLSAGAM
  129-  148 (29.50/20.03)	VPEPyRYFDNKVDDLSSDTM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04251 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DRKYRKHRSEDKDRKKEKKKKKDKKRKRDSKEEDQNNKVRKV
176
217










Molecular Recognition Features






MoRF SequenceStartStop




1) DLDRKYRKHRSEDKDRKKEKKKKKDKKRKRDSKEEDQNN
2) PYRYFDN
174
132
212
138