<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04238

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAAIDTSRVDGTGAPVAALKQHMANNGSTTPQQEQQQVTKTPPPIPHITNNFIPLKTIISSMVLYASAELRNVLETLPATSSDLTKKRRLLDYIVKMRVQFVKIYVLMKWVKVSKDISTNIDVVAWLNGQQNCFQNVIEALKFIEKSLGGAKLRNPDLETALEVFTAGRPAHPLHGFVPVQKLSAKTILQTLYDLNILLSIRLALTEKLPPEFSHYQIANGRVTFFVENSYQVQLGIADDSVDARFFLVDFQFDFPGAHVPAPATRAKLETIANGILPTKGLVNLFETLLKFTQNYKLALMYAELVELGKGLYQGLILPKFYPERSLVTVSYWLSAASAAAAKNVTKNQIEIGLRRDKTIGIRWSREGTVVNDHGIEFGQTNISTEWLLQEITTLHVRHNIATIHAILAKYNHVRGANGNAKTARNVRPGSTTTSAPTPSESTSPAGAVTPTANNSLDTFNNTPEVATLVSPEKIKIHLTESRYTIYSIDRLSGRAILTNSTKLIASAEAALNDNYDKPIQVAGLLVKLRHASVQEEIIAKAKSAGWITTTNMPFSNDAVRSQFPPDTRLLFCLRQGTWPARWFLLVTIGSDSQPRWWISQLVIRDGLWHILFSEEVHVKRDNPNHFDYKMFRDLSTFTIRHIQTEALCKELDLNNVKYKLLQSAGDSSGAPVILIDMRTLTQGTWAEETLFLTLVEERADKTVAVLQGKSKQALDIGSMSSDSSRMEVDATTGGFTLNMVLPDSCLASPAYLSGRYRLPNAIKTEGPKKSEFIEHLVNKFSQIERIVSYVNLLKSLSLELKEASMTKITFEYGPGLAAEITLQGSAVAAPNASGVLAASSTHSLSETAVLRLPRESPHHFVEPFLQSMLNSDGLLSVVWVLQTALPLYTALKDVMALAEEKFTAMTAATTTAATTAATGANGTRNNATFPLVVTPHSVFEIQLFFPHKRVRVLLRLMEVNGRPLSVFVTEVFQAGQAPHLSGPAPTSLPPAAQQALQQQQQAHKTSLLAPLWTQRSDIPGVVPLVQGLACPIASIDRVLRRIFDILV
Length1049
PositionTail
OrganismGeotrichum candidum (Oospora lactis) (Dipodascus geotrichum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Dipodascaceae> Geotrichum.
Aromaticity0.07
Grand average of hydropathy-0.044
Instability index47.59
Isoelectric point9.09
Molecular weight115511.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04238
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.44|      16|     502|     417|     432|       1
---------------------------------------------------------------------------
  417-  432 (30.26/18.26)	GANG...NAKTARNVRPGS
  921-  939 (26.17/14.83)	GANGtrnNATFPLVVTPHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.55|      13|     106|     575|     587|       2
---------------------------------------------------------------------------
  575-  587 (27.32/13.97)	LRQGTWPARWFLL
  682-  694 (24.23/11.69)	LTQGTWAEETLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.87|      65|     146|     815|     889|       4
---------------------------------------------------------------------------
  736-  800 (109.54/71.69)	GFTLNMVLPDSCLASP...AYL..SGRYRLPNAIKTEGPKKS..EFIEHLVNKFSQIERIVSYVNLLK.SLSL
  817-  889 (87.33/80.69)	GLAAEITLQGSAVAAPnasGVLaaSSTHSLSETAVLRLPRESphHFVEPFLQSMLNSDGLLSVVWVLQtALPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.13|      23|     963|      34|      56|       7
---------------------------------------------------------------------------
   34-   56 (44.52/24.49)	QEQQQVTKTPPPIPHITN.....NFIPL
  999- 1026 (36.61/18.90)	QQQQQAHKTSLLAPLWTQrsdipGVVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      10|     805|     164|     173|      10
---------------------------------------------------------------------------
  164-  173 (19.92/13.94)	EVFTAGRPAH
  972-  981 (20.20/14.25)	EVFQAGQAPH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04238 with Med14 domain of Kingdom Fungi
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