<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04228

Description "Similar to Saccharomyces cerevisiae YPL042C SSN3 Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme"
SequenceMFNYSNGQKRPNKQQFSSSSAAASSSAVTAQKLKAYYEQQQSLRRSQSQHPQHSQQPHPQHYQQQQQQQQQQQQQQQQQQQQQQQQHQLGQDAYWRSDAALKDTPKKYSGYPTDPKMSLINDPLSSFKKRKDSKRKRVLDSYDIVGYIAAGTYGKVYKAKPKNVKSDNKLYAIKKFKADKEGEVVHYTGVSQSACREMALCRELNHRNVIKLAEIILEDKCIYMAFEYAEHDLLQIIHYHTHPDRKQIPESIVKSVLWQILNGVSYLHQNWVLHRDLKPANIMLTADGVVKVGDLGLARLYSDPLQSFFTGDKVVVTIWYRAPELLLGGRHYTPAIDLWAVGCIFAELLALRPIFKGEEAKMDSKKTVPFQRNQFQKVTDILGSPTVEQWPSLVKYPEFPSFHALKPCKPNLDSWYRSIDCHNTKGFRLLQSLFEYDPAKRITAQEALMHPYFSEAPQVSMNVFHGHKYNYPVRRITVEDIDIKGAAYTGSSNKRNVAAADDSLHPRKKHK
Length511
PositionKinase
OrganismGeotrichum candidum (Oospora lactis) (Dipodascus geotrichum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Dipodascaceae> Geotrichum.
Aromaticity0.10
Grand average of hydropathy-0.739
Instability index60.90
Isoelectric point9.46
Molecular weight58850.12
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04228
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.81|      37|      43|     108|     145|       2
---------------------------------------------------------------------------
  108-  145 (60.62/46.22)	YSG.YPTDPKMSLINDPLSSFKKRKDSKRKRVLDsYDIV
  153-  190 (59.20/40.22)	YGKvYKAKPKNVKSDNKLYAIKKFKADKEGEVVH.YTGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.42|      12|      34|     434|     446|       3
---------------------------------------------------------------------------
  434-  446 (17.66/17.81)	FEYdPAKRITAQE
  469-  480 (22.76/16.43)	YNY.PVRRITVED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.91|      14|      34|      38|      55|       4
---------------------------------------------------------------------------
   38-   74 ( 9.81/ 8.81)	EQQQslrrSQSQHPQHSqqphpqhyqqqqqqqqqqqQ
   75-   88 (27.10/12.15)	QQQQ....QQQQQQQQH...................Q
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04228 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MFNYSNGQKRPNKQQFSSSSAAASSSAVTAQKLKAYYEQQQSLRRSQSQHPQHSQQPHPQHYQQQQQQQQQQQQQQQQQQQQQQQQHQLGQDAYWRSDAALKDTPKKYSGYPTDPKMSLINDPLSSFKKRKD
1
132










Molecular Recognition Features






MoRF SequenceStartStop




1) AADDSLHPRKKHK
2) ASSSAVTAQKLKAYYEQQQSLRRSQSQHPQHSQQPHPQHYQQQQQQ
3) KLYAIK
4) MFNYSN
5) MSLINDPL
6) PKKYSGYPTD
7) QQHQLGQDAYW
8) RVLDSYDIVGYIAAGTYGKVY
499
23
169
1
117
105
85
137
511
68
174
6
124
114
95
157