<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04221

Description Mediator of rna polymerase ii transcription subunit 24
SequenceMETSKVTSKTSSLKALLLRAWRERWTDLQWGINIKTILPRGVSGDVYNLADCILQQALVGSGPNQLVLSYLKHSLSSQLVSYAAVLQRISKYDAFHKPHCILSLLEFLESIQIGITCRGKPEEDLLAAAVLSIVHWLLQCYLYALTFAPQSNSLTPQSSELIDKPASILQQMLNSDFMCAMMYLAKYDDKDLYIDVVKQCQEIESLLKTCSQKSAVPIEDSLKKLCNLEIESLCLEKIRMESITHCLQPLFAVQVLLNPSTETAVFVNQLLMVQRLKSYTNARLYCEIIRACLMCLHNVTGTFKESQWGAFTFLKVPLILKELHAATLNDEKFEYSQDILDAFELLLQFTPLLDIMDSTCSCNYVECLLNELQKVNLVTEKQAKQISARREGVTAALQKLEPSSTPTSSIPKVIIRAKPTLAGILKTLNADYTKIQEALLSMLYHVLTGNSFELMLAVATVEGKLKTFVAKLIKFNESSKQINEPVPDKTAATRAMLFDVSFLMLCSIVQTYGSDVVLEEGGDSFFEQWVYECMPERNKPKSPQRMLQSVDPARVDALLAQINSPDPDFKSSNLKWHVACQSAMGAVKELLCAWESGVLGAGDVKRALDGLRTAACCLPVCAAAWLCAYMSITHQDALLKPMNMVQHFLTPLPGDEMQDNLKERSSLMFQIIRKMQYDVHPPTQSKTKVLSMSHSIISRQPILEQLESVWQNINQRGWINIQATQSLESLLNTGGSLWFVTNIVKEVLKYRYQEELEQAVDLAFAIFHLDIEDCTLDLLNHIIPQYLHNSLQSDELVEPQSSILAKLCVYCIFSTLEYINSNPYRGNNRKRVRSDFDMDDLDALGMSNKHLRLNETGESVPMFGSQSPQAQSSSNGQKSMVVLKEPLMTALNNLFTIFAFLAGRDGEKDVFFIANDQASSMWQKLDNVLTIPMETKVTSKTSSLKALLLRAWRERWTDLQWGINIKTILPRGVSGDVHNLADCILQQALVGPGPNQLVLSYLKHSLSSQLVSYAAVLQRISKYDAFHKPHCILSLLEFLESIQIGITCRGKPEEDLLAAAVLSIVHWLLQCYLQALTKAPQNNPLTPHSSELIDKPASILQQVLNSDFLCAMMYLAKYDDKDLYIDVVKKCQEIETLSKTSSQKSVVAIEDSLKKLCNLEIESLCPEKTKMESITHCLQPLFAVQVLLNPSTETTVFVNQLLMVQRLKSYTNARLYCEIIRACLMCLHNVTGTFKESQWGAFMFLKVPLILKELHATTVNGDEKLEYSQDILDAFELLLQFTPLLDIMDSTCSCNYVECLLNELQKVNLVTEKQAKQISARREGVTAALQKLEPSSTPTSSIPKVIICAEPTLAGILKTLNADYTKSSLLSMLYHVLNSFELMLAVATVEGKLKTFVTKLIKLNECSKQINEPVPGKTAATRAMSFDVSFLMLCSIVQTYGSDVVLEEGGDSFFEQWVRECMPERKKPKSPQRMLQSVDPARVDALLTQLNSPDPDFKSSNLKWHVACQSAMGAVKELLCAWESGVLGAGDVKMALDGLRTAACCLPVCAAAWLCAYMSITHQDALLKPMNMVQHFLTPLPSDEMQDNLKESIISRQPILEQLESVWQNINQRGWINIQATQSLESLLNTGGSLWFVTNIVKEVLKYRYQEELDQAVDLAFAIFHLDIENCTLDLINHIIPQYLDNSLQSDELVEPQSSILAKLCVYCIFSTLEYNNSNPYRSNSRKRVRRDLDADELDPLGVSNKLLRLNETGESVPMFGSQSPQAQGSNNGQKSMVVLRDPLMTALNNLFTMFAFLAGRDGEVCQQTHFIFQFLRFTVQCGKDRTRIVLQGMPQTLVPCLLKALPELFTTDILLRLYDIQAVIGRMATARDLCMLRNINLKPTK
Length1886
PositionTail
OrganismLasius niger (Black garden ant)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Formicinae> Lasius> Lasius.
Aromaticity0.07
Grand average of hydropathy-0.011
Instability index48.54
Isoelectric point5.87
Molecular weight211784.47
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04221
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.93|      11|      83|     481|     506|       1
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  101-  111 (14.94/11.33)	ILSLLEFLESI
  496-  506 (21.99/ 6.31)	MLFDVSFLMLC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.85|      20|      83|     556|     575|       2
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  556-  575 (40.59/28.97)	DALLAQIN......SPDP.DFKSSNLK
  636-  662 (31.46/20.36)	DALLKPMNmvqhflTPLPgDEMQDNLK
 1484- 1503 (40.34/28.73)	DALLTQLN......SPDP.DFKSSNLK
 1564- 1590 (31.46/20.36)	DALLKPMNmvqhflTPLPsDEMQDNLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.18|      25|      81|      76|     100|       3
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   76-  100 (55.09/41.59)	SSQLVSYAAVLQRISKYDAFHKPHC
 1007- 1031 (55.09/41.59)	SSQLVSYAAVLQRISKYDAFHKPHC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     263.01|      33|      83|     784|     816|       4
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  149-  184 (48.05/26.10)	PQ..SNSLtpQSSELIDKP..................ASILQQMLnsdFMCAMMYL
  185-  210 (29.67/13.14)	AKYDDKDL..YIDVVKQCQ................eiESLL.KTC...........
  784-  816 (65.66/38.51)	PQYLHNSL..QSDELVEPQ..................SSILAKLC...VYCIFSTL
 1089- 1115 (29.70/13.17)	...........SSELIDKP..................ASILQQVLnsdFLCAMMYL
 1116- 1157 (23.91/ 9.08)	AKYDDKDL..YIDVVKKCQeietlsktssqksvvaieDS.LKKLC...........
 1681- 1713 (66.02/38.77)	PQYLDNSL..QSDELVEPQ..................SSILAKLC...VYCIFSTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.92|      26|     388|     213|     245|       5
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  213-  245 (44.02/49.61)	KSAVPIEdslkklcNLEIESLCLEKIRMESITH
 1144- 1176 (43.90/31.32)	KSVVAIEdslkklcNLEIESLCPEKTKMESITH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    2545.12|     668|     929|       1|     928|       6
---------------------------------------------------------------------------
    1-  913 (1260.50/945.56)	METsKVTSKTSSLKALLLRAWRERWTDLQWGINIKTILPRGVSGDVYNLADCILQQALVGSGPNQLVLSYLKHSLssqlvsyaavlqriskydafhkphcilslleflesiQIGITCRGKPEEDLLAAAVLSIVHWLLQCYLYALTFApqsnslTPqsselidkpasilqqmlNSDfmcammylakyddkdlyidvvkqcqEIesllktcSQksavpiedslkklcnleieslclekirmesithCLQPLFAVQVLLNPSTETAVFVNQLLMVQRLKSYTNARLYCEIIRACLMCLHNVTGTFKESQWGAFTFLKVPLILKELHAATLN.DEKFEYSQDILDAFELLLQFTPLLDIMDSTCSCNYVECLLNELQKVNLVTEKQAKQISARREGVTAALQKLEPSSTPTSSIPKVIIRAKPTLAGILKTLNADYTKiqEALLSMLYHVLtgNSFELMLAVATVEGKLKTFVAKLIKFNESSKQINEPVPDKTAATRAmlfdvsflmlcSIVQTYGSDVVLEEGGDSFFEQWVYECMPERNKPKSPQRMLQSVDPARVdallaqinspdpdfkssnlkWHVACQSAMGAVKELLCAWESGVLGAGDVKRALDGLRTAACCLPVCAAAWLCAYMSITHQdallkpmnMVQHFLtplpgdemqdnlkErsslmfqiirkmqydvhpptqsktkvlsmshSIISRQPILEQLESVWQNINQRGWINIQATQSLESLLNTGGSLWFVTNIVKEVLKYRYQEELEQAVDLAFAIFHLDIEDCTLDLLNHIIpqylhnslqsdelvepqssilaklcvycifstlEYINSNPYRGNNRKRVRSDFDMDDLDALGMSNKHLRLNETGESVPMFGSQSPQAQSSSNGQKSMVVLKEPLMTALNNLFTIFAFLAGRDGE..KDVFFI
  933- 1812 (1284.62/860.65)	MET.KVTSKTSSLKALLLRAWRERWTDLQWGINIKTILPRGVSGDVHNLADCILQQALVGPGPNQLVLSYLKHSLssqlvsyaavlqriskydafhkphcilslleflesiQIGITCRGKPEEDLLAAAVLSIVHWLLQCYLQALTKApqnnplTPhsselidkpasilqqvlNSDflcammylakyddkdlyidvvkkcqEIetlsktsSQksvvaiedslkklcnleieslcpektkmesithCLQPLFAVQVLLNPSTETTVFVNQLLMVQRLKSYTNARLYCEIIRACLMCLHNVTGTFKESQWGAFMFLKVPLILKELHATTVNgDEKLEYSQDILDAFELLLQFTPLLDIMDSTCSCNYVECLLNELQKVNLVTEKQAKQISARREGVTAALQKLEPSSTPTSSIPKVIICAEPTLAGILKTLNADYTK..SSLLSMLYHVL..NSFELMLAVATVEGKLKTFVTKLIKLNECSKQINEPVPGKTAATRAmsfdvsflmlcSIVQTYGSDVVLEEGGDSFFEQWVRECMPERKKPKSPQRMLQSVDPARVdalltqlnspdpdfkssnlkWHVACQSAMGAVKELLCAWESGVLGAGDVKMALDGLRTAACCLPVCAAAWLCAYMSITHQdallkpmnMVQHFLtplpsdemqdnlkE...............................SIISRQPILEQLESVWQNINQRGWINIQATQSLESLLNTGGSLWFVTNIVKEVLKYRYQEELDQAVDLAFAIFHLDIENCTLDLINHIIpqyldnslqsdelvepqssilaklcvycifstlEYNNSNPYRSNSRKRVRRDLDADELDPLGVSNKLLRLNETGESVPMFGSQSPQAQGSNNGQKSMVVLRDPLMTALNNLFTMFAFLAGRDGEvcQQTHFI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04221 with Med24 domain of Kingdom Metazoa
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