<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04217
Description |
Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MEEGGQQKGITAAFPPPPPFWKKFTPENLERLEKAKREAEPQALSRKWSPEALHALKLAPELRYLVPPELPKEGSYSLFGEAQSLSTQLPSLEEQGIEQLYPSSLTNETAGPSPDHAYYLLKISKSLLLNFLELVGILSINPEQYEPKIEDIRNLFINAHHLLNLYRPHQSRESLITMMEEQLEQAKEEIREMEQTKERVEIYLRELEAEGRNVSPNDEPVQTPESGPHNTKTQTSESQANGEQPLWAALTQPFAPRKPNSLSRFCTVNMTHRYQPCTAPGSYFPDPFGMRSLGSHECRLLGEERFNPSPRASLQAQIFSIRST |
Length | 324 |
Position | Middle |
Organism | Coccidioides immitis RMSCC 2394 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.717 |
Instability index | 61.60 |
Isoelectric point | 5.45 |
Molecular weight | 36818.08 |
Publications | PubMed=20516208
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060
ECO:0000256 ARBA:ARBA00003669
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04217
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 125.22| 30| 30| 263| 292| 1
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244- 258 (19.69/ 6.42) ............QPLWAA....LTQPFAPRK
263- 292 (60.83/32.76) SRFCTVNMTHRYQPCTAP.GSYFPDPFGMRS
295- 323 (44.71/22.44) SHECRLLGEERFNP..SPrASLQAQIFSIRS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.44| 23| 32| 108| 131| 2
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108- 131 (35.30/26.52) ETAGPSPDHAYYLLkISKSLLLNF
143- 165 (40.15/25.61) EQYEPKIEDIRNLF.INAHHLLNL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 126.55| 39| 39| 22| 60| 3
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22- 60 (65.02/33.35) KKFTPENLERLEKAKREAEPQALSRKW.SPEALHALKLAP
63- 102 (61.53/31.21) RYLVPPELPKEGSYSLFGEAQSLSTQLpSLEEQGIEQLYP
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