<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04216

Description Uncharacterized protein
SequenceMASLNTPECPVMSSRPSMSCGNSSSSGLAIQGHSQRPSQTDPSAVEQAAQDSVIDLTNSDYETCDANRATKRQKLDLRIDVPNTQRAPKARFSQAVSSPFALQDTVPPIRTGRPFWDFGEEVSGFGFQGSLESEIPNDEPEQPDSLPPLPVRPWRYRPQGHSSREETPRVNQNAGAEVQTTPFCIEVPEAAPIFDSGKPLDFYPWKGDHPEDSLTDQTAKQGYYDRVQVSQNESNTARPSLYVQLKHRSGLKLLSSVFTAAIDKRQSHCRVTGFSTFKPPPRVTLTDIKRETWLRDLANPSVPLRRLSRTIPHGIRGRILLDQCVNKAIPIGRAVWLVKCVGANEIRAFKRKGTSAAITHSLEVKWVRDWSINVHQFIESVVTACGTPNWASTMSYVIRFAARLFQEQLLDQALCLDWFLQSLRTAPIGTLPIWLSMLGAYWTSLVRYRKRGRPLAESLLEKLKTILSLEDSGPKKQIADRLSWLIKTFAESHPACFVLPLTWRTYKSALTTCFCLHLSEDNRKIGALSNRNERIVKAEICRQSGRQSPSQQVICLLDSADSLNDMEILSSGCLNLHFDHGSLIMKILEWVSTSFRRGSARVYVAVRLLRKWRRAGMDTDNCIVNFLQQKADTPGFSPANIYHLVCELVRSQSFAVGKYLQWLMARGAVRNDAPMHPTVQLLAHLPRRKLPSHVWNLRNTLLTKAGFLLSSENQQILNTKRYIHHRLPEVITKPIAGDNEGLFTPSDLSNLNWTIKSEIGHWIREHVSLHRKRYLRTAPNHHNACAIEISALTPAQFFEIRDIIECLGDLSLLADILKHTSSSDNIIVLISAVDTLNYCADSFKAIGALSDLFKSALAGYAHVNKADVSIIELISSLLEVGMKLPGEIPVVAMLRRDLSHFDKKFTGAVSSPVSDHTGESVNIASPAFSEGLHQLLNSGSGMDEPNMNKIFDMLSRKLKQSKEPNASSHEIARHLSQLRVLNSDVFDRLMVKWIISTLKSSPRPHLLTFLPPLIGVGCVTFEAFFALIDRLLKSDSHRQSIQDVSGLRYEMINLLRKEIFYELGSIDLVSYRFKTTREEYITHHAYDALGLVNEALANVNPESTSHPPLVPLLCELIIQNLNAFGPEGAGRIVEEFPNCVDIIHQALDVLLGLKAQVGVQKTQSVVGLIDDLSLSYCLVKLRLLLDANPDGDAARSSIVDLLFRTAESDIRNGERRWLEVLNVLPVSAAHLIRQRAEREILSLSLISSSLTTFASEEDALIYLCIVEELSYSIPDEFSPSSMGADLGDKMFLLLQKTVELANAKKGTDLESGASSTALGVAELSIGVWFFVLLRLVALHRSLVPPNCDSRTEINHQTRLLVQICCISRSPLFARRSTQSFISSISTFTKCDSLLRMLPSSWANLQLQALDVCSTLVDTLSDEARYECARFLRDKCPAFLHPQNDARLLFLFGPIIESQSITTHGSSRASTSTPVTNLTQHVQSTPPPSQNTLTPGMVEEPNLFTNKLRFQQNGRITGPYPPKPWEMLGDAAPIIGINDTPVNLAYFGTRQSKRL
Length1554
PositionKinase
OrganismCoccidioides immitis RMSCC 2394
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.07
Grand average of hydropathy-0.174
Instability index50.45
Isoelectric point8.37
Molecular weight173358.52
Publications
PubMed=20516208

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04216
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     212.72|     104|     205|    1137|    1255|       1
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  821-  878 (56.82/27.66)	SSSDNIIVLISAVDTLNYCADS......FKAIGALSDLFKSAlagyAHV..NKADVSI..IELISSLL.........................................................................................................................................................................................................................................................................................................................
 1137- 1186 (57.67/25.63)	....................................................................evgmklpgeipvvamlrrdlshfdkkftgavsspvsdhtgesvniaspafseglhqllnsgsgmdepnmnkifdmlsrklkqskepnassheiarhlsqlrvlnsdvfdrlmvkwiistlkssprphlltflppligvgcvtfeaffalidrllksdshrqsiqdvsglryeminllrkeifyelgsidlvsyrfkttreeyithhaydalglvnealanvnpestshpplvpllceliiqnlnafgpegagriveefPNC...VDIIHQA.LDVLLGLKAQVGVQKTQSVVGLIDDLS.LSYCLVKLRLLLD
 1187- 1250 (49.44/51.71)	ANPDGDAARSSIVDLLFRTAESdirngeRRWLEVLNVLPVSA....AHLirQRAEREIlsLSLISSSL.........................................................................................................................................................................................................................................................................................................................
 1345- 1399 (48.79/19.91)	........................................................................................................................................................................................................................................ttfaseedaliylciveelsysipdefspssmgadlgdkmflllqktvelanakkgtdlesgasstalgvaelsigvwffvllrlvalhrslvpPNCdsrTEINHQTrLLVQICCISRSPLFARRSTQSFISSIStFTKCDSLLRMLPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.12|      43|      49|     134|     179|       2
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  134-  179 (73.15/62.15)	EIPNDEPeQPDSLPPLPVRPWRYRPQGHSSREETPRvnQNAGAEVQ
  186-  228 (80.97/56.89)	EVPEAAP.IFDSGKPLDFYPWKGDHPEDSLTDQTAK..QGYYDRVQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.85|      53|     205|     389|     447|       3
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  389-  447 (86.77/91.00)	NWASTM....S...YViRFAARLFQE...QLLDQALCLDWFLQSLRTAP.....................IGTLPIWLSMLGAywtslVR
  449-  485 (33.07/18.37)	.................RKRGRPLAE...SLLEK...LKTILSLEDSGP..................kkqIADRLSWL............
  589-  670 (62.01/47.05)	EWVSTSfrrgSarvYV...AVRLLRKwrrAGMDTDNCIVNFLQQKADTPgfspaniyhlvcelvrsqsfaVGKYLQWLMARGA.....VR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     287.42|     103|     380|    1027|    1136|       4
---------------------------------------------------------------------------
  680-  752 (82.75/49.03)	QLLAHLPRRKLPSHVWNLRN...TLLTKAGFL.LSSENqqiLNTKRYIHHRlPEVITKPiAGDNEGLFTPSdLSNLN.........................................
 1030- 1136 (169.05/133.63)	RLLKSDSHRQSIQDVSGLRYemiNLLRKEIFYeLGSID...LVSYRFKTTR.EEYITHH.AYDALGLVNEA.LANVNPESTSHPP.....LVPLLCELIIQNLNAFGPEGAGRIVEEF
 1476- 1519 (35.62/15.66)	..........................................................................NLTQHVQSTPPpsqntLTPGMVEEPNLFTNKLRFQQNGRITGPY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     373.79|     113|     228|      15|     129|       5
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   15-  129 (188.44/152.97)	RPSMSCGNSSSSGLAIQGH......SQRPSQTDPSAVEQAAQDSVIDLTNSDYETCDANRATKRQKL.DLRIDVPNTQRApKARFSQAVSSPFAlQDTVPPIRTGRPFWDF....GEEVSGFGFQG
  238-  353 (161.46/120.74)	RPSLYVQLKHRSGLKLLSSvftaaiDKRQSHCRVTGFSTFKPPPRVTLTDIKRETWLRDLANPSVPLrRLSRTIPHGIRG.RILLDQCVNKAI.......PI..GRAVWLVkcvgANEIRAFKRKG
  894-  930 (23.89/ 9.66)	.....................................................................LRRDLSHFDK....KFTGAVSSPVS.DHTGESVNIASP..AF....SE.........
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04216 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQGSLESEIPNDEPEQPDSLPPLPVRPWRYRPQGHSSREETPRVNQNAGAEVQTTP
2) MASLNTPECPVMSSRPSMSCGNSSSSGLAIQGHSQRPSQTDPSAVEQAAQDSVIDLTNSDYETCDANRATKRQKLDLRIDVPNTQRAPKARFSQAVSSPFALQD
3) THGSSRASTSTPVTNLTQHVQSTPPPSQNTLTPGMV
127
1
1462
182
104
1497










Molecular Recognition Features






MoRF SequenceStartStop




1) VRPWRYR
151
157