<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04214

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLAMDGPSAMASRATVADMHYDPASASQQANGGIYRNGIGKKSHSPVDGLHDSHIGCLHELPPELSHITLGFFPFNNLISRVVQQSWNDLNELLNEMGSSQAYQTGISSQLSATKNGMSEKFRGDQATENSLKKLRILEFTHSRRAEFIKLLVLSQWSRQANEVSRLIDIQAFIRMRSGFYEAALFHIGNMKQNLIVAQLANPDLKTASHVLSAGKIDALHGLEFLSPRPLAPSQVLRLLRGINKLIDMRLALHDHVPDSLQNYFVHDGRVTFIVPNEFEIDLSVASAAPSAQFFLVDMKFLFFPSSLPKGRLRSIVDHQVNSTLMNAGLVGCFNLLHNLILTHKITILFKQAIDLARTYWSEHLRVELFHRTLVLQYWSKKPGGKSWIEIGVHSGLKGSPQSTGTTTSFLQLRWFRDNEEVSATDIDFNLTFLSAKSILFSAISLHITHILRTAFEALRQNRLYCLGGLYIGMSASSKEPGDCYLELQMTQTSHLDIMVEAVSGDTVLRVAPSPITRYDTEIIVDRGSVEDIVERVSRLRCVSALEEVERYAKAVGWMPLNLRHVNLESLKRIFPPSALRSMLLFRAKCWEPSWLAVFTSAMDGDNWWIVQLQTQNPPALQSHWRLLEAQRAKLITGWFTGWLGRLHNASFSSLLSALSGMIMVQCNVDFLNEIGAIHFFPPPKDLLLQPCLRVPSIYLRLRHDDFPSQFRTIFSGGSPRRSFIDETFRISYKGIDQQSGHAITMVYGRLMTDIDMFGALYAKSVQDIAFQPKGRGFAILFRTPVGTPIIAPLLERLQQMNNIAFVVESMKSQGFQPHSLSPLRIKFSYPTQGELRGSIKFIYHDQGSHFESKLLFPATTTKPILHPRIGIDFNYQNPHRRITESLSTILNSHKDVTLERICAEEYIDNAWCFRAQYTARSARLYQIRYPFLRYRFNVSASQRKSYVVWVIQNSTPGPERSKHPSLELRLKDQIYNSQGDGWRGINQGAMAYSANVSRLVFDLHQLMKSYISQMAKSNQRGEPTDSSPSAGCEFGRYLPKNENKKGHIQTTTAPTLEHAYGNSNMVVQSVRQGEAAARDVDVIAID
Length1089
PositionTail
OrganismCoccidioides immitis RMSCC 2394
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.09
Grand average of hydropathy-0.190
Instability index47.12
Isoelectric point9.21
Molecular weight122860.36
Publications
PubMed=20516208

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP04214
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.34|      63|      74|     398|     468|       1
---------------------------------------------------------------------------
  398-  468 (92.63/81.22)	GLKGSPQSTGttTSFLQLRWfrdnEEVSATDIdfNLTFLSAKSIL...FSAISLHITHIL..RTAFEAL..RQNRLYC
  475-  544 (95.71/61.08)	GMSASSKEPG..DCYLELQM....TQTSHLDI..MVEAVSGDTVLrvaPSPITRYDTEIIvdRGSVEDIveRVSRLRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.14|      66|      76|     166|     240|       2
---------------------------------------------------------------------------
  166-  240 (98.95/79.12)	VSRLIDiqafirMRSGFYE...AAL..FHIGNMKQNLIVAQLANPDLKTASHVLSAGKIdaLHGLEFL.SPRPLaPSQVLR
  245-  316 (98.19/57.97)	INKLID......MRLALHDhvpDSLqnYFVHDGRVTFIVPNEFEIDLSVASAAPSAQFF..LVDMKFLfFPSSL.PKGRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.68|      23|      74|     773|     795|       3
---------------------------------------------------------------------------
  773-  795 (42.68/31.04)	FQPKGRGFA..ILFRTPVGTPIIAP
  846-  870 (39.00/27.62)	YHDQGSHFEskLLFPATTTKPILHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.51|      41|      78|     548|     592|       5
---------------------------------------------------------------------------
  548-  592 (60.39/55.84)	LEEVERYAKAVGWMPLNLRHVNLESLKRIFppSALRSMLLfrAKC
  629-  669 (72.12/49.90)	LLEAQRAKLITGWFTGWLGRLHNASFSSLL..SALSGMIM..VQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.65|      12|      17|     351|     364|       6
---------------------------------------------------------------------------
  351-  364 (18.45/15.25)	LFKQAIDLArtYWS
  371-  382 (24.20/13.12)	LFHRTLVLQ..YWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.12|      50|      67|      37|      89|       8
---------------------------------------------------------------------------
   37-   89 (84.62/61.82)	YRNGIGKKSHSPVDGLHDSHIGclhELPPELSHITLGFFPFN.....NLISRVVQQSW
  105-  159 (76.49/47.21)	YQTGISSQLSATKNGMSEKFRG...DQATENSLKKLRILEFThsrraEFIKLLVLSQW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04214 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAKSNQRGEPTDSSPSAGCEFGRYLPKNENKKGHIQTTTAPTLEHAYGNSN
1017
1067










Molecular Recognition Features






MoRF SequenceStartStop




NANANA