<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04210
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MHEHSLFAPVPAAQHHDLLQQLAGVTAMQPNRIYERRLVFKPYRKPGYLKPRPGGSQDVQAPEVQRLNKMLNGGLYHVQVVGEVKLTDFGTHPSTVDATMGGTDFGNQHQNEYDISNQSWRIEFKDIPDAGTGSAVTSRLISTSRVPYGDIVPVMKAWGYDYVSEYVLEGDMFILDDTVILLHRILNFPAKHHLQGLPAFYLPPLQEMVPLDSTGGYLLQASITVQDSGNPDLMKATTQRLLGLKEHLKSAVRLESADRLSLDTRVK |
Length | 267 |
Position | Head |
Organism | Coccidioides immitis RMSCC 2394 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.336 |
Instability index | 36.63 |
Isoelectric point | 6.40 |
Molecular weight | 29814.62 |
Publications | PubMed=20516208
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Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP04210
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.79| 11| 14| 87| 97| 2
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87- 97 (22.18/14.84) TDFGT.HPSTVD
103- 114 (18.62/11.41) TDFGNqHQNEYD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 122.00| 41| 54| 147| 195| 3
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147- 195 (62.06/63.49) PYGDIVPVmkawgyDYVSEYVLEGDMFILD....DTV.ILLHRILNFpaKHHLQ
204- 249 (59.94/39.33) PLQEMVPL......DSTGGYLLQASITVQDsgnpDLMkATTQRLLGL..KEHLK
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