Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MLRRVSSASVPQSPLLEPQKSQWHHRLPHSTPTAHLDDRAAHVRFPSPFMTATPQSYASSFSTTQSTSPAQSASQSAPDSSSPPSSLAMSAQPAQQLTVTNAFPTPASSVSGVAKESQDPSEKAARALMETAEGAPGFTDIDNGILQNQQSPQNQQGTIAGLIPQEDAMDIDRKDDLSEDPKIAALQQDIGQAFHTCKSSYSISGPSPRFDLISLYGLGPVAASVARTDPVTGEKINRLRKSYEGKIKGLGLSGRNKAVKREPGAPGGLRQLTMWPEEEWQNQKVIGKDIRVAEPDSALHKLHMRAMKFEPGPVPNNDYWEDVLGHEKPPKQGAAAVQPKKAADTVGGAVRQSTQANGTPISTPAPPVESGRPKRAGKKRSYNDSSFVGYGEGFPDDDLDMDGGFYSNSEEGARGSAKKKRKKDHVPVVPPSLTERKGSYGVGMFGVGTR |
Length | 450 |
Position | Head |
Organism | Coccidioides immitis RMSCC 2394 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.727 |
Instability index | 59.80 |
Isoelectric point | 8.86 |
Molecular weight | 48154.09 |
Publications | PubMed=20516208 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP04206 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 225.05| 55| 57| 45| 99| 1 --------------------------------------------------------------------------- 6- 45 (39.08/15.91) .............SSASVPQSplLEPQKSQWHHRLPHSTPTAHLDDRAAH.........vrF 46- 103 (84.95/43.94) PSPFMTATPQSYASSFSTTQS..TSPAQSASQSAPDSSSPPSSLAMSAQPAQ..QLTVtnaF 104- 159 (67.35/33.19) PTPASSVSGVAKESQDPSEKA..ARALMETAEGAPGFTDIDNGILQNQQSPQnqQGTI.... 179- 208 (33.66/12.60) EDPKIAALQQDIGQAFHTCKS..S...YSISGPSP........................... --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DYWEDVLG 2) FVGYGEGFPDDDLDMDGGFY 3) KKKRKKDHVPVV 4) MLRRVS | 318 387 418 1 | 325 406 429 6 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab