<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04194

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAPDILAGQPLRPTTPIPGLWLLDAPETLYVRVYTAPPIVPCDPPPPETTGTPQPEQNGEEKPDASLSLSPARLAIPAVAPSPALSLPGIRSPTALRSPVAALKSQPGTPSQTEVKLSPTRTTHSFIPRPPSPSTTLDRLRNDPLERAWLAINASDSDVTAAVLKRPCAVVKPGGERRELWVFSPDDAPASALESLGLTEVDVPQPIRIADTVTCSEHGHTLDCLSPDTDDKCVPTFTPPESWPLLESAVGEKVAWKLGTRLSLLPSDATLADPPFDVSLRPAPGKLILTAQLRPLPSCAPQRHNRTDPGVDPLVLRPLALPALLVAPVGPTPAQDVRLSAAFDLALGSGWKNGRSEARVAAQAAHGCAYDWSVYWVPLERGEEDLARTLPHALATKWRGSNGVLTVWPTHLARPLARSLPPVPAKFVPPDSALGSPFDLMSIATEVFDFLGSYTAPAEDDDDDGEEEPPEANGDVAMDDGSKESDADDLFSAHTSPAPTASRAVSRAPTIGTDVGELFTSSAFGTPGLNALDVDMGLDEDLFGDDDADTVVPDREEAGDTTPAPVMLPPPIPTNTQLSSKVGSPREVTEDDFNFFDSPAAETSPAKIFHAPHPPLDDHTGKELAVLATPAAAYLSIPLPDATPASLSSALEDEPEALTEVQVQILPEPEVILTEAVEECMTKPSSPSIVLVEEEPRKRRYIDIVPDAFAPVQLGTSKRPKFAYGLPSPAATVSSLRLGCVERLRESVSGKEKAVAFPYTAAWDIESDGSDSECESAVTTGAPPTPSSTVSYDDRTPTNELAALPALPDDEVEYDGTVCIGGEWTSLQFDINAAATLARAWAVSWVDIRPEPDYPTPTSPPRLAEPQQPTLNVELFANAIVRNSFFRALFETSDVTARELPRPASMIVRGGVPVSDVAGALADSERYSLEQPSVHVGYGSNVMRVNVAALRYWRELGLMPSGGPKDLAAFVICAPGAYNVQRAQTFLTDISEVFEANRLGTLVAGAHELATDGVAAVPSVEVWSTASRLRGTSLVGKPTVVFVLTSTTTLSPASLVPLLAPKAQTNWVYPLPLSSLRPSNLATIAFQVYDLVPRHVDRVTMFGKPLDMPKLWMGFHAFTLAGEEAPKPELSMAWPQRSYDVLNRWRQVHAAYAWVPEWETAIVAVVDAQGDALDVQALKLEKCTTRDRVSRVWDVVLSFAAEAATEWRASITRYGLMSVDELDAWKWLYNGHTDAMSLLMCEPSSDGPNRTRAPVANIPPSTFADPSASIIDEALAASAASFNHRLCVTLPPGGTGSTPTIFPPASFALGMAGPAATSVATATYHVLLHRNPPGRSEKADELLAPEFYRLACLGRRRYALGALPLPLDAVGAVSAALGRIEKPVEAEVEKKEEDD
Length1395
PositionKinase
OrganismCutaneotrichosporon oleaginosum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Cutaneotrichosporon.
Aromaticity0.06
Grand average of hydropathy-0.156
Instability index50.99
Isoelectric point4.67
Molecular weight149124.54
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     185.09|      33|      49|      69|     101|       1
---------------------------------------------------------------------------
   10-   32 (33.03/ 8.32)	..PLR......P.TTPIPGLWL..LDAP..ETLY..VR
   33-   65 (47.94/15.26)	VYTAPPI...VPCDPPPPETT..GTPQPeqNGEEKPDA
   69-  101 (55.58/18.81)	LSPARLA...IPAVAPSPALSLPGIRSP..TALRSPVA
  117-  151 (48.55/15.54)	LSPTRTThsfIPR.PPSPSTTLDRLRND..PLERAWLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     232.43|      48|      49|     264|     311|       2
---------------------------------------------------------------------------
  264-  288 (28.98/ 8.73)	...........................LLPSDATLADPPFDVS.LRPAPGKLI
  289-  337 (64.24/29.32)	LTAQLRPLPSCAPQRHNRTDPGVdplvLRP....LALPALLVApVGPTPAQDV
  339-  382 (69.57/32.43)	LSAAF.DLALGSGWKNGRSEARV......AAQAA.HGCAYDWS.VYWVPLERG
  383-  428 (69.64/32.47)	EEDLARTLPH.ALATKWRGSNGV..ltVWPTH..LAR.PLARS.LPPVPAKFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.75|      37|      49|    1140|    1179|       3
---------------------------------------------------------------------------
 1140- 1179 (56.15/56.91)	DVLNR.WRQV..HAAYAwVPEWETAIVAVVDAQGDALDvqALK
 1187- 1226 (58.59/43.92)	DRVSRvWDVVlsFAAEA.ATEWRASITRYGLMSVDELD..AWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.54|      19|      65|     555|     573|       4
---------------------------------------------------------------------------
  555-  573 (37.15/14.91)	REEAGDTTPAPVMLPPPIP
  598-  615 (26.35/ 8.38)	.SPAAETSPAKIFHAPHPP
  622-  640 (30.04/10.61)	KELAVLATPAAAYLSIPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.89|      18|      49|     839|     859|       6
---------------------------------------------------------------------------
  839-  859 (31.13/23.70)	RA.WAVSWVDIRpepDYPTPTS
  887-  905 (27.76/12.15)	RAlFETSDVTAR...ELPRPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.12|      33|      39|    1280|    1313|       7
---------------------------------------------------------------------------
  220-  245 (33.52/12.53)	....HTLdCLS.PDTDDKCVPTFTPPESWPL....
 1280- 1313 (56.43/30.87)	ASFnHRL.CVTLPPGGTGSTPTIFPPASFALGMAG
 1322- 1354 (56.17/26.79)	ATY.HVL.LHRNPPGRSEKADELLAPEFYRLACLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.45|      16|      27|     486|     501|      11
---------------------------------------------------------------------------
  492-  519 (20.21/ 8.15)	SAHTSPAPTAsravsraptigtDVG.ELF
  522-  543 (19.24/ 7.34)	SAFGTPGLNA.......ldvdmGLDeDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.08|      33|     284|     697|     751|      12
---------------------------------------------------------------------------
  719-  751 (59.06/52.75)	RPKFAYG.LPSP..AATVSSLRLGCVERLRES.VSGK
 1355- 1391 (43.01/10.78)	RRRYALGaLPLPldAVGAVSAALGRIEKPVEAeVEKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04194 with Med13 domain of Kingdom Fungi
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