<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04193

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSALQGQRPPAGAQPGQSSAAGPSASAPSGPLHEQPQPVASSSRNPQLGPHPYFRYPTPTPDQIEEELPPYWEDENVPLGPLLDRLARKSYSDMRTLVEKTLPPLAPRQKPKHVIEYAKTTRQAVLKYLAVLRWKMSVDLATTTQPHANGLPAAAAFPTPHSNGESNNTSPVAFPSKGKGRVDGTAEEPVVRGKVTDARRIQHFLEHQNQQQEAAITHIRHVTGMIDMLRERNADLLTALSLQSTGTYSRLPAQLMEDWVPRAPLQPPAVLANIERLNEHTRYRLRCVDYVPPDLVVERVADGRVYARGGGENGWIAQLSLEGFEEDSKWWLCGFEWAWKVDGAESPKPFSTPELNQILAMCNHEVLAPQEGEGDNVDEGDANADKAKVDAPLVRVYNFLQHLSLAYQLEVLYSQALAMTQGRWRGQLQVEIDRTKKELRLRYWIRQRTQAPPVAAPGVKRPPQAPTVSSVNNQRPMVGGTLTFTLAEATSPMSEAERVLREVAVCGAEPADRTVRFELGIKWEVGEAGTGGGLKAGEAMDASGLKIDPSSLSMKGIVTAATRAHAAHLSRVNTTPLLTNERLILDPLNPPRMEESESSSTRPVSLVVPLPSRGQLSIAVSSISGLLEIEDSIARDNGQVMENNRTLRAKLATNSSNEQKTRLADDVYRLVSAIIVEDIEDNLRQLGLHPLRRVALRTNDLSKTDLHPSTTVFVPLPVSQNHYFVAKVTTKGIAYELLKLLRVPMEGNGGMKMSVGERIPIDLAKLVERRAAKGAKRNLDGEETSADMAMLKWESAAGKSGPFQVHARDLRDMFTYCNALVAQTMVEQQLKDRGIPYTAQFPDEDDFAVPRSRSALAGMVPNLCVNASHLFKDGRAAEVASPKVFLVIKNWWSGSQCNVETIVRLRHQPSLDSQPAAPVARASDAGRAEGITFDQNTLTVRFHAPSIARCVPDFLEQWERLSKVIVVAGEVNRLNKQEEFRDIRMLSFDLCTASVQYAPGFNVAITYTPTSDSYEASFSRTAVHGATPALGGPHSDGGDNPHAALAPLLSAHLNELTQLAPVGGRGHAGRDFLQLLRATLPLLLEAEALRVASASPYPALVVRSVMEYRLVWDHEAKTPARYALDVLLTQAGSARFLLCDATRRKDVPEDLTCGPLTPIPNIANAMLKGFQAAKIAKVSTPSGPAGTPRTPNPKTPGKGITPKEARVKTITPVMPPAARLDGGESMICSLGVMHEVLRAISNEIEISIGGVPMGPGSARG
Length1260
PositionTail
OrganismCutaneotrichosporon oleaginosum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Cutaneotrichosporon.
Aromaticity0.05
Grand average of hydropathy-0.330
Instability index43.27
Isoelectric point7.65
Molecular weight137335.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04193
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     569.37|     184|     656|      47|     403|       1
---------------------------------------------------------------------------
   90-  293 (296.83/352.62)	SYsDMRTLVEKTLPPLAPRQKPKHVIEYAKTTRQAVLKYlavlrW.KMSVDLATTTQPHANGLPAAAAFPT.....PHSNGE.....SNNTSPVAFPSKGKGRVDGTAEEPvvrgkvtDARRIQHFLEHQNQQQEAA......ITHIRHVTGM.IDMLRERNADLLTALSLQSTGTYSRLPAQ..LMEDWVPRAPLQPPavlanieRLNEHTRYRLRCVDYVPP
  406-  609 (272.54/104.20)	AY.QLEVLYSQALAMTQGRWRGQLQVEIDRTKKELRLRY.....WiRQRTQAPPVAAPGVKRPPQAPTVSSvnnqrPMVGGTltftlAEATSPMSEAERVLREVAVCGAEP.......ADRTVRFELGIKWEVGEAGtggglkAGEAMDASGLkIDPSSLSMKGIVTAATRAHAAHLSRVNTTplLTNERLILDPLNPP.......RMEESESSSTRPVSLVVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.04|      46|     162|     825|     874|       2
---------------------------------------------------------------------------
  825-  874 (72.17/47.31)	MVEQQLKDRGIPYTAQF.......PDEDDFAVPRSRSALAGMVPNLcvNASHlfKDG
  985- 1037 (77.87/39.90)	MLSFDLCTASVQYAPGFnvaitytPTSDSYEASFSRTAVHGATPAL..GGPH..SDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.80|      52|    1150|      16|      70|       5
---------------------------------------------------------------------------
   16-   70 (94.50/54.04)	GQSSAAGPSASAPSGPlheQPQPVASSSRNPQLGPHP.YFRYPTPTPDQIEEELPP
  685-  708 (26.17/ 6.99)	...............................QLGLHP.LRRVALRTNDLSKTDLHP
 1169- 1216 (81.12/39.87)	GFQAAKIAKVSTPSGP...AGTPRTPNPKTPGKGITPkEARVKTITP.....VMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.00|      62|     559|     330|     402|       6
---------------------------------------------------------------------------
  330-  402 (95.32/94.64)	WW...LCGFEWAWKVdgAESPKPFSTPelNQILAMcnhevlAPQEGEGDNVDEgDANADKAKVDAP.LVR.VYNFLQH
  891-  957 (97.68/64.64)	WWsgsQCNVETIVRL..RHQPSLDSQP..AAPVAR......ASDAGRAEGITF.DQNTLTVRFHAPsIARcVPDFLEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.86|      23|      24|     750|     772|       7
---------------------------------------------------------------------------
  750-  772 (38.70/20.94)	GMKMSV.GERIPIDLAKLVERRAA
  774-  797 (33.15/17.00)	GAKRNLdGEETSADMAMLKWESAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04193 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSALQGQRPPAGAQPGQSSAAGPSASAPSGPLHEQPQPVASSSRNPQLGPHPYFRYPTPTPDQIEEELPPYWEDENVPL
2) RKSYSDMRTLVEKTLPPLAPRQKPKHVIEY
3) TTTQPHANGLPAAAAFPTPHSNGESNNTSPVAFPSKGKGRVDGTAEEPVVRG
4) VSTPSGPAGTPRTPNPKTPGKGITPKEARVKTITPVMPP
1
88
142
1178
79
117
193
1216










Molecular Recognition Features






MoRF SequenceStartStop




1) LGPHPYFRYPTPT
2) QIEEELPPYW
48
63
60
72