<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04188

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDIDQPNGDDAGSSRPSPFADVKLSVDAYTLDAASGKRRLKEIEPDGSLTFEEPKPPRVKATEELARIWNLYPGGMPELREADVRAADPSTEYNEPEPEEDKGGESREPGTLMSPAEMEKLRSEVVQDLNSARNELWWVLELAKTLASSASFTADPPPEPIAAAGPQRKKAPPPKTAAAPAPPAPPGAKTDEVPPILPPGTYTTTPAAPPERPAAVVAHELELALAAKAAALDDCAALIDAAVDELRLMNEAGTRWAAEIRALRLGNEGRGQWAVVPKPDFGRTGESAKDVVIPYALDEAPSSVHARSMAAFDLDPRKDALAFGARSYYRLRVVFRTGGSGGPQTASQPYDANAETGGAAEMLAAAQLETVDEELFNELRVEALRLDVALVEPQNISLRVGKDKLSFQLYDSRAPHDDLPTSARCDALLAGARLGLLHKYQRRKQKLIDNPLVPSQSILFPLVNLLQFAAACRTVSPVLQGFADALSAAGRPTKLVARFSACESPDAVVGLLAARTKVDVLGAVYTLEIEECPGLTVTVTAPAVLSVTTPRATFPLRDADGLAPLAADAVATQLSALAYPVVREAAGGESVVFFDELDQVVIAGSLGPLSITLPAPYDRVLASVESAAVEGYDSADASQSLDEWLGDLGRAAVTES
Length656
PositionHead
OrganismCutaneotrichosporon oleaginosum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Cutaneotrichosporon.
Aromaticity0.05
Grand average of hydropathy-0.182
Instability index53.52
Isoelectric point4.66
Molecular weight69518.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04188
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.05|      16|      16|     241|     256|       1
---------------------------------------------------------------------------
  241-  256 (29.22/19.82)	AAVDELRLMNEAGTRW
  258-  273 (29.83/20.39)	AEIRALRLGNEGRGQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.03|      12|      16|     337|     348|       3
---------------------------------------------------------------------------
  337-  348 (22.60/12.37)	TGGSGGPQTASQ
  356-  367 (20.42/10.49)	TGGAAEMLAAAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.27|      28|      40|      36|      63|       4
---------------------------------------------------------------------------
   36-   63 (48.17/23.02)	GKRRLKEIE...PDGSLTFEEPKPPRVKATE
   75-  105 (43.10/19.86)	GMPELREADvraADPSTEYNEPEPEEDKGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      12|      16|     379|     390|       5
---------------------------------------------------------------------------
  379-  390 (18.42/11.77)	LRVEALRLDVAL
  398-  409 (20.00/13.38)	LRVGKDKLSFQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.68|      15|      21|     172|     186|       6
---------------------------------------------------------------------------
  172-  186 (31.76/12.35)	PP..PKTAAAPAPPAPP
  194-  210 (27.92/10.01)	PPilPPGTYTTTPAAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.08|      14|      16|     295|     308|       7
---------------------------------------------------------------------------
  295-  308 (24.30/13.40)	YALDEAPSSV..HARS
  312-  327 (19.78/ 9.47)	FDLDPRKDALafGARS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04188 with Med17 domain of Kingdom Fungi
Unable to open file!