<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04186

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTTTMSVQDLTGRASARAIPPRKWAKLVAEWVERESLDTEAAGPAVAAALLHHLSRPRPPALLISYLSQALEEGLLTARAFALALLAHMQRDEPTLSAALLASIATALLGTPTGLDPTEPFPSPIALPTPDVGTSASGESNAVPALTLVLPLLRHCVSGPPQLLALAARLTALIPPLPAPPFEAGLEAAQLSGVLPEEVAKPLRDCLTGLMADLPMPEAAPQPALFHDVPIVSGFAELDGVPQLSNLPTTLPLRQMTSFLIEFAERAQSSTPSSSYASDPPHPPQHLIYLIRLGRALTSDSQAYLLALLEAASNRVIASLNLSPGQATRAYVFFTEELPVALRWWRDNADSKWPFPSNLQNALAGTFASHNQEMAGWHASVHATHTAKSTQLMDDDEVGGYSPPDGWSMLSLEATTVRRYLSLGLLDEEQAVALSESAKAGPVGESLVERLSGVQQHHLEAIAYFISYATGASRHLGAELVNVIKNAPHSRPPENLFLRVAGSPPLLALVTAYITPKSLLDLIVTHLLDHVEDQSSRIEDPQTSLTHFGPGVVLAVALCAQFDLPLPDLLYDGRRASNIADLSSSEQSHLNGWVKALFGSDGIDDEIILATSSQGLCRLAPTIVQQAIVATMSGQLDLDTLHSGLSYFAQPILSWCLGGVVGWLCAEIERQGILSGVHLNVLQTLVLDSAFPEPLLRANAPAIARLLDPATGLEPVMLSSAFDAAGVRARINVLGGPDGGPVVVPSDPAAPLVSLRAELANVQHLDLAPAGWESRLYDILDISLRTAGALPVLESIVSTDIIYPPTLDSPPNSPEVQFLAFVSVLNMPHACAPPLAVALIDAYLPYLFTQRSPFVPLAAMPAPTQTMLSSTTPAHNPPPLPFASHALHHLLRGALLAADAYTSEEGGFADYLANHLSDEFACQRARPAFTSPRQKRSRVGALGVVDALCPEQKELICELISLFEGDEEIRSRWPNLTPMSTMGPATGPAS
Length990
PositionTail
OrganismCutaneotrichosporon oleaginosum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Trichosporonales> Trichosporonaceae> Cutaneotrichosporon.
Aromaticity0.06
Grand average of hydropathy0.138
Instability index55.43
Isoelectric point4.99
Molecular weight105374.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04186
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     480.92|      87|     122|      43|     129|       1
---------------------------------------------------------------------------
   43-  120 (121.76/47.38)	......................GPAVA.A..ALLHHLSRPR...PPALLISYLSQALEEGL..LT.ARAFALALL.AHMQRDEPTLSAALLAS..............IATALLGTPTG......LDPTEP
  121-  213 (101.39/38.27)	FPSPIALPTpdvgtsasgesnaVPALT.LvlPLLRHCVSG....PPQLLA..LAARLTALIppLP.APPFEAGLE.A......AQLSGVLPEE..............VAKPLRDCLTG......L..MAD
  279-  354 (73.06/25.59)	......................DP...............PH...PPQHLI.YLIR.LGRAL..TSdSQAYLLALLeAASNR....VIASLNLSpgqatrayvffteeLPVALRWWRDN......ADSKWP
  691-  751 (79.43/28.44)	FPEPLLRAN.............APAI..A..RLLDPATG.................LEPVM..LS.S.AF...........DAAGVRARI....................NVLGGPDGgpvvvpSDPAAP
  807-  881 (105.27/40.01)	LDSP...PN.............SPEVQfL..AFVSVLNMPHacaPP.LAVA.LIDAYLPYL..FT.QRSPFVPLA.AMPAPTQTMLSSTTPAH..............NPPPL.................P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.22|      23|     107|     398|     430|       2
---------------------------------------------------------------------------
  398-  430 (30.29/37.61)	VGGYSPPDgwSMLSLEATTvrrylslgLLD..EEQ
  510-  534 (35.93/18.42)	VTAYITPK..SLLDLIVTH........LLDhvEDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.47|      30|     389|     541|     583|       3
---------------------------------------------------------------------------
  541-  573 (48.07/40.25)	PQTSLTHFGPGVV...LAVALCAQFDLplpDLLYDG
  612-  644 (46.40/16.67)	SSQGLCRLAPTIVqqaIVATMSGQLDL...DTLHSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.78|      30|     218|     357|     397|       4
---------------------------------------------------------------------------
  357-  397 (34.92/44.02)	SNLQNaLAGTFASHnqeMAGWhasVHATHTAKSTqlmdDDE
  577-  606 (53.85/29.55)	SNIAD.LSSSEQSH...LNGW...VKALFGSDGI....DDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04186 with Med5 domain of Kingdom Fungi
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